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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

IMPACT FACTOR 2018: 1.221

CiteScore 2018: 1.01

SCImago Journal Rank (SJR) 2018: 0.329
Source Normalized Impact per Paper (SNIP) 2018: 0.479

ICV 2017: 152.94

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Volume 8, Issue 5


Volume 10 (2015)

Blue toe syndrome as the initial manifestation of ANCA-associated vasculitis

Liubomir Marinchev / Maria Hristova / Marta Baleva / Zlatimir Kolarov
Published Online: 2013-09-18 | DOI: https://doi.org/10.2478/s11536-012-0142-5


The blue (or purple) toe syndrome describes the development of a blue or violaceous discoloration in one or more toes in the absence of obvious trauma, serious cold-induced injury or disorders producing generalized cyanosis. The presence of blue toe syndrome requires the clinician to search for primary systemic vasculitides, as well as for malignancy, underlying infection, thrombosis, cardiovascular pathology and other diseases. An accurate diagnosis is critical because many of the causes threaten life or limb, but the patient’s medical history, accompanying non-dermatologic findings on physical examination and the use of discriminatory laboratory tests are usually more important than the nature of the cutaneous abnormalities. We describe the case of a 53-year-old Caucasian male patient presenting with blue toe syndrome as the initial manifestation of ANCA-associated vasculitis.

Keywords: Blue toe syndrome; ANCA-associated vasculitis

  • [1] Hirschmann J. V. and Raugi G.J., Blue (or purple) toe syndrome, J. Am. Acad. Dermatol., 2009, 60, 1–20 http://dx.doi.org/10.1016/j.jaad.2008.09.038CrossrefGoogle Scholar

  • [2] Hahn B. H., Vasculitis: Attack of the Leukocytes, Lupus News, 2003, 23 Google Scholar

  • [3] Pipitone N., Holl-Ulrich K., Gross W.L., Lamprecht P., Unclassified vasculitis with acral ischemic lesions: “form fruste” or idiopathic vasculitis, Clin. Exp. Rheumatol., 2008, 26(3 suppl. 49), S 41–66 Google Scholar

About the article

Published Online: 2013-09-18

Published in Print: 2013-10-01

Citation Information: Open Medicine, Volume 8, Issue 5, Pages 577–579, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-012-0142-5.

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© 2012 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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