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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew


IMPACT FACTOR 2018: 1.221

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Volume 9, Issue 2

Issues

Volume 10 (2015)

Prevalence and predictors of potential drug-drug interactions

Bozana Nikolic
  • Health Centre Novi Sad, Vase Stajica 38, 21000, Novi Sad, Serbia
  • Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia
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/ Slobodan Jankovic
  • Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia
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/ Oliver Stojanov
  • Health Centre Novi Sad, Vase Stajica 38, 21000, Novi Sad, Serbia
  • Department of Geriatrics, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia
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/ Jovan Popovic
  • Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia
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Published Online: 2014-02-13 | DOI: https://doi.org/10.2478/s11536-013-0272-4
  • [1] Michalets E.L., Williams C.R., Drug interactions with cisapride: clinical implications, Clin. Pharmacokinet., 2000, 39, 49–75 http://dx.doi.org/10.2165/00003088-200039010-00004CrossrefGoogle Scholar

  • [2] Juntti-Patinen L., Neuvonen P.J., Drug-related deaths in a university central hospital, Eur. J. Clin. Pharmacol., 2002, 58, 479–482 http://dx.doi.org/10.1007/s00228-002-0501-2CrossrefGoogle Scholar

  • [3] Pirmohamed M., James S., Meakin S., Green C., Scott A.K., Walley T.J., et al., Adverse drug reactions as cause of admission to hospital: prospective analysis of 18820 patients, BMJ., 2004, 329, 15–19 http://dx.doi.org/10.1136/bmj.329.7456.15Google Scholar

  • [4] Zed P.J., Abu-Laban R.B., Balen R.M., Loewen P.S., Hohl C.M., Brubacher J.R., et al., Incidence, severity and preventability of medication-related visits to the emergency department: a prospective study, CMAJ., 2008, 178, 1563–1569 http://dx.doi.org/10.1503/cmaj.071594CrossrefGoogle Scholar

  • [5] Patel P., Zed P.J., Drug-related visits to the emergency department: how big is the problem?, Pharmacotherapy, 2002, 22, 915–923 http://dx.doi.org/10.1592/phco.22.11.915.33630CrossrefGoogle Scholar

  • [6] Guédon-Moreau L., Ducrocq D., Duc M.F., Quieureux Y., L’Hôte C., Deligne J., et al., Absolute contraindications in relation to potential drug interactions in outpatient prescriptions: analysis of the first five million prescriptions in 1999, Eur. J. Clin. Pharmacol., 2003, 59, 689–695 http://dx.doi.org/10.1007/s00228-003-0684-1CrossrefGoogle Scholar

  • [7] Huang S.M., Lesko L.J., Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned?, J. Clin. Pharmacol. 2004, 44, 559–569 http://dx.doi.org/10.1177/0091270004265367CrossrefGoogle Scholar

  • [8] Moura C.S., Acurcio F.A., Belo N.O., Drug-drug interactions associated with length of stay and cost of hospitalization, J. Pharm. Pharm. Sci., 2009, 12, 266–272 Google Scholar

  • [9] Einarson T.R., Metge C.J., Iskedjian M., Mukherjee J., An examination of the effect of cytochrome P450 drug interactions of hydroxymethylglutarylcoenzyme A reductase inhibitors on health care utilization: a Canadian population-based study, Clin. Ther. 2002, 24, 2126–2136 http://dx.doi.org/10.1016/S0149-2918(02)80102-3CrossrefGoogle Scholar

  • [10] Saurat J.H., Guérin A., Yu A.P., Latremouille-Viau D., Wu E.Q., Gupta S.R., et al., High prevalence of potential drug-drug interactions for psoriasis patients prescribed methotrexate or cyclosporine for psoriasis: associated clinical and economic outcomes in real-world practice, Dermatology, 2010, 220, 128–137 http://dx.doi.org/10.1159/000275198CrossrefGoogle Scholar

  • [11] Pergolizzi J.V. Jr., Labhsetwar S.A., Amy Puenpatom R., Ben-Joseph R., Ohsfeldt R., Summers K.H., Economic impact of potential CYP450 pharmacokinetic drug-drug interactions among chronic low back pain patients taking opioids, Pain Pract., 2012, 12, 45–56 http://dx.doi.org/10.1111/j.1533-2500.2011.00503.xCrossrefGoogle Scholar

  • [12] Pergolizzi J.V. Jr., Labhsetwar S.A., Puenpatom R.A., Ben-Joseph R., Ohsfeldt R., Summers K.H., Economic impact of potential drug-drug interactions among osteoarthritis patients taking opioids, Pain Pract., 2012, 12, 33–44 http://dx.doi.org/10.1111/j.1533-2500.2011.00498.xCrossrefGoogle Scholar

  • [13] Hamilton R.A., Briceland L.L., Andritz M.H., Frequency of hospitalization after exposure to known drug-drug interactions in a Medicaid population, Pharmacotherapy, 1998, 18, 1112–1120 Google Scholar

  • [14] Obreli-Neto P.R., Nobili A., de Oliveira Baldoni A., Guidoni C.M., de Lyra Junior D.P., Pilger D., et al., Adverse drug reactions caused by drug-drug interactions in elderly outpatients: a prospective cohort study, Eur. J. Clin. Pharmacol., 2012, 68, 1667–1676 http://dx.doi.org/10.1007/s00228-012-1309-3CrossrefGoogle Scholar

  • [15] van Roon E.N., Flikweert S., le Comte M., Langendijk P.N., Kwee-Zuiderwijk W.J., Smits P., et al., Clinical relevance of drug-drug interactions: a structured assessment procedure, Drug Saf., 2005, 28, 1131–1139 http://dx.doi.org/10.2165/00002018-200528120-00007CrossrefGoogle Scholar

  • [16] Tatro D.S., Drug Interaction Facts? 2012 — The authority on drug interactions, Facts and Comparasions, St. Louis, Wolters Kluwer Health, 2011 Google Scholar

  • [17] Aparasu R., Baer R., Aparasu A., Clinically important potential drug-drug interactions in outpatient settings, Res. Social. Adm. Pharm., 2007, 3, 426–437 http://dx.doi.org/10.1016/j.sapharm.2006.12.002CrossrefGoogle Scholar

  • [18] Grönroos P.E., Irjala K.M., Huupponen R.K., Scheinin H., Forsström J., Forsström J.J., A medication database a tool for detecting drug interactions in hospital, Eur. J. Clin. Pharmacol., 1997, 53, 13–17 http://dx.doi.org/10.1007/s002280050330CrossrefGoogle Scholar

  • [19] Merlo J., Liedholm H., Lindblad U., Björck-Linné A., Fält J., Lindberg G., et al., Prescriptions with potential drug interactions dispensed at Swedish pharmacies in January 1999: cross sectional study, BMJ., 2001, 323, 427–428 http://dx.doi.org/10.1136/bmj.323.7310.427CrossrefGoogle Scholar

  • [20] Bergendal L., Friberg A., Schaffrath A., Potential drug-drug interactions in 5125 mostly elderly outpatients in Gothenburg, Sweden, Pharm. World Sci., 1995, 17, 152–157 http://dx.doi.org/10.1007/BF01879709CrossrefGoogle Scholar

  • [21] Costa A.J., Potential drug interactions in an ambulatory geriatric population, Fam. Pract., 1991, 8, 234–236 http://dx.doi.org/10.1093/fampra/8.3.234CrossrefGoogle Scholar

  • [22] Obreli Neto P.R., Nobili A., Marusic S., Pilger D., Guidoni C.M., Baldoni Ade O., et al., Prevalence and predictors of potential drug-drug interactions in the elderly: a cross-sectional study in the brazilian primary public health system, J. Pharm. Pharm. Sci., 2012, 15, 344–354 Google Scholar

  • [23] Björkman I.K., Fastbom J., Schmidt I.K., Bernsten C.B., Pharmaceutical Care of the Elderly in Europe Research (PEER) Group, Drug-drug interactions in the elderly, Ann. Pharmacother., 2002, 36, 1675–1681 http://dx.doi.org/10.1345/aph.1A484CrossrefGoogle Scholar

  • [24] Janchawee B., Wongpoowarak W., Owatranporn T., Chongsuvivatwong V., Pharmacoepidemiologic study of potential drug interactions in outpatients of a university hospital in Thailand, J. Clin. Pharm. Ther., 2005, 30, 13–20 http://dx.doi.org/10.1111/j.1365-2710.2004.00598.xCrossrefGoogle Scholar

  • [25] Cruciol-Souza J.M., Thomson J.C., Prevalence of potential drug-drug interactions and its associated factors in a Brazilian teaching hospital, J. Pharm. Pharm. Sci., 2006, 9, 427–433 Google Scholar

  • [26] Doubova-Dubova S.V., Reyes-Morales H., Torres-Arreola Ldel P., Suárez-Ortega M., Potential drugdrug and drug-disease interactions in prescriptions for ambulatory patients over 50 years of age in family medicine clinics in Mexico City, BMC. Health Serv. Res., 2007, 7, 147 http://dx.doi.org/10.1186/1472-6963-7-147CrossrefGoogle Scholar

  • [27] Nobili A., Pasina L., Tettamanti M., Lucca U., Riva E., Marzona I., et al., Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database, J. Clin. Pharm. Ther., 2009, 34, 377–386 http://dx.doi.org/10.1111/j.1365-2710.2009.01021.xCrossrefGoogle Scholar

  • [28] Lin C.F., Wang C.Y., Bai C.H., Polypharmacy, aging and potential drug-drug interactions in outpatients in Taiwan: a retrospective computerized screening study, Drugs Aging, 2011, 28, 219–225 http://dx.doi.org/10.2165/11586870-000000000-00000CrossrefGoogle Scholar

  • [29] Bjerrum L., Andersen M., Petersen G., Kragstrup J., Exposure to potential drug interactions in primaryhealth care, Scand. J. Prim. Health Care., 2003, 21, 153–158 http://dx.doi.org/10.1080/02813430310001806CrossrefGoogle Scholar

  • [30] Johnell K., Klarin I., The relationship between number of drugs and potential drug-drug interactions in the elderly: a study of over 600000 elderly patients from the Swedish Prescribed Drug Register, Drug Saf., 2007, 30, 911–918 http://dx.doi.org/10.2165/00002018-200730100-00009CrossrefGoogle Scholar

  • [31] Gagne J.J., Maio V., Rabinowitz C., Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy, J. Clin. Pharm. Ther., 2008, 33, 141–151 http://dx.doi.org/10.1111/j.1365-2710.2007.00891.xCrossrefGoogle Scholar

  • [32] Janchawee B., Owatranporn T., Mahatthanatrakul W., Chongsuvivatwong V., Clinical drug interactions in outpatients of a university hospital in Thailand, J. Clin. Pharm. Ther., 2005, 30, 583–590 http://dx.doi.org/10.1111/j.1365-2710.2005.00688.xCrossrefGoogle Scholar

  • [33] Carthy P., Harvey I., Brawn R., Watkins C., A study of factors associated with cost and variation in prescribing among GPs, Fam. Pract., 2000, 17, 36–41 http://dx.doi.org/10.1093/fampra/17.1.36CrossrefGoogle Scholar

  • [34] Rahmner P.B., Gustafsson L.L., Larsson J., Rosenqvist U., Tomson G., Holmström I., Variations in understanding the drug-prescribing process: a qualitative study among Swedish GPs, Fam. Pract., 2009, 26, 121–127 http://dx.doi.org/10.1093/fampra/cmn103CrossrefGoogle Scholar

  • [35] Wun Y.T., Chan C.S., Dickinson J.A., Determinants of physicians’ attitude towards prescribing, J. Clin. Pharm. Ther., 2002; 27, 57–65 http://dx.doi.org/10.1046/j.1365-2710.2002.00389.xCrossrefGoogle Scholar

  • [36] WHO Collaborating Centre for Family of International Classifications. International Classification of Diseases. Available from: http://www.who.int/classifications/icd/en/ Accessed: 2012 December Google Scholar

  • [37] WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index. Available from: http://www.whocc.no/atc_ddd_index/ Accessed: 2012 December Google Scholar

  • [38] Fulda T.R., Valuck R.J., Zanden J.V., Parker S., Byrns P.J., Disagreement among drug compendia on inclusion and ratings of drug-drug interactions, Curr. Ther. Res., 2000, 61, 540–548 http://dx.doi.org/10.1016/S0011-393X(00)80036-3CrossrefGoogle Scholar

  • [39] Vitry A.I., Comparative assessment of four drug interaction compendia, Br. J. Clin. Pharmacol., 2007, 63, 709–714 http://dx.doi.org/10.1111/j.1365-2125.2006.02809.xCrossrefGoogle Scholar

  • [40] Rätz-Bravo A.E., Tchambaz L., Krähenbühl-Melcher A., Hess L., Schlienger R.G., Krähenbühl S., Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy, Drug Saf., 2005, 28, 263–275 http://dx.doi.org/10.2165/00002018-200528030-00007CrossrefGoogle Scholar

  • [41] Chatsisvili A., Sapounidis I., Pavlidou G., Zoumpouridou E., Karakousis V.A., Spanakis M., et al., Potential drug-drug interactions in prescriptions dispensed in community pharmacies in Greece, Pharm. World Sci., 2010, 32, 187–193 http://dx.doi.org/10.1007/s11096-010-9365-1CrossrefGoogle Scholar

  • [42] Jones J.D., Mogali S., Comer S.D., Polydrug abuse: a review of opioid and benzodiazepine combination use, Drug Alcohol Depend., 2012, 125, 8–18 http://dx.doi.org/10.1016/j.drugalcdep.2012.07.004CrossrefGoogle Scholar

  • [43] Gelkopf M., Bleich A., Hayward R., Bodner G., Adelson M., Characteristics of benzodiazepine abuse in methadone maintenance treatment patients: a 1 year prospective study in an Israeli clinic, Drug Alcohol Depend., 1999, 55, 63–68 http://dx.doi.org/10.1016/S0376-8716(98)00175-6Google Scholar

  • [44] Stitzer M.L., Griffiths R.R., McLellan A.T., Grabowski J., Hawthorne J.W., Diazepam use among methadone maintenance patients: patterns and dosages, Drug Alcohol Depend., 1981, 8, 189–199 http://dx.doi.org/10.1016/0376-8716(81)90061-2CrossrefGoogle Scholar

  • [45] Teixeira J.J., Crozatti M.T., dos Santos C.A., Romano-Lieber N.S., Potential drug-drug interactions in prescriptions to patients over 45 years of age in primary care, southern Brazil, PloS One, 2012, 7, e47062 http://dx.doi.org/10.1371/journal.pone.0047062CrossrefGoogle Scholar

  • [46] Secoli S.R., Figueras A., Lebrão M.L., de Lima F.D., Santos J.L., Risk of potential drug-drug interactions among Brazilian elderly: a populationbased, cross-sectional study, Drugs Aging, 2010, 27, 759–770 http://dx.doi.org/10.2165/11538460-000000000-00000CrossrefGoogle Scholar

  • [47] Rosholm J.U., Bjerrum L., Hallas J., Worm J., Gram L.F., Polypharmacy and the risk of drug-drug interactions among Danish elderly. A prescription database study, Dan. Med. Bull., 1998, 45, 210–213 Google Scholar

  • [48] Hohl C.M., Dankoff J., Colacone A., Afilalo M., Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department, Ann. Emerg. Med., 2001, 38, 666–671 http://dx.doi.org/10.1067/mem.2001.119456CrossrefGoogle Scholar

  • [49] Rambhade S., Chakarborty A., Shrivastava A., Patil U.K., Rambhade A., A survey on polypharmacy and use of inappropriate medications, Toxicol. Int., 2012, 19, 68–73 http://dx.doi.org/10.4103/0971-6580.94506CrossrefGoogle Scholar

  • [50] Reason B., Terner M., Moses McKeag A., Tipper B., Webster G., The impact of polypharmacy on the health of Canadian seniors, Fam. Pact., 2012, 29, 427–432 http://dx.doi.org/10.1093/fampra/cmr124CrossrefGoogle Scholar

  • [51] Veehof L.J., Stewart R.E., Meyboom-de Jong B., Haaijer-Ruskamp F.M., Adverse drug reactions and polypharmacy in the elderly in general practice, Eur. J. Clin. Pharmacol., 1999, 55, 533–536 http://dx.doi.org/10.1007/s002280050669CrossrefGoogle Scholar

  • [52] Lopez-Picazo J.J., Ruiz J.C., Sanchez J.F., Ariza A., Aguilera B., Lazaro D., et al., Prevalence and typology of potential drug interactions occuring in primary care patients, Eur. J. Gen. Pract., 2010, 16, 92–99 http://dx.doi.org/10.3109/13814788.2010.481709CrossrefGoogle Scholar

  • [53] Sloan R.W., Drug interactions, Am. Fam. Physician, 1983, 27, 229–238 Google Scholar

About the article

Published Online: 2014-02-13

Published in Print: 2014-04-01


Citation Information: Open Medicine, Volume 9, Issue 2, Pages 348–356, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-013-0272-4.

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