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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

IMPACT FACTOR 2018: 1.221

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Volume 9, Issue 4


Volume 10 (2015)

Antibiotics in severe acute pancreatitis

Alejandro Serrablo / Luis Tejedor / Jessica Martínez
Published Online: 2014-07-19 | DOI: https://doi.org/10.2478/s11536-013-0281-3


Acute pancreatitis (AP) is a local inflammatory response with systemic effects and an adverse evolution in 20% of cases. Its mortality rate is 5–10% in sterile and 15–40% in infected pancreatic necrosis. Infection is widely accepted as the main reason of death in AP. The evidence to enable a recommendation about antibiotic prophylaxis against infection of pancreatic necrosis is conflicting and difficult to interpret. Up to date, there is no evidence that supports the routine use of antibiotic prophylaxis in patients with severe AP. Treatment on demand seems to be the better option, avoiding excessive treatment and selection of bacterial. In infected acute pancreatitis, antibiotics of choice are imipenem, meronem or tigecycline in patients allergic to beta-lactams. Also fluconazole must be given in determinate clinical situations.

Keywords: Acute pancreatitis; Antibiotic prophylaxis; Antibiotic treatment

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About the article

Published Online: 2014-07-19

Published in Print: 2014-08-01

Citation Information: Open Medicine, Volume 9, Issue 4, Pages 565–573, ISSN (Online) 2391-5463, DOI: https://doi.org/10.2478/s11536-013-0281-3.

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© 2014 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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