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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

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IMPACT FACTOR 2016 (Open Medicine): 0.294
IMPACT FACTOR 2016 (Central European Journal of Medicine): 0.116

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2391-5463
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Volume 10, Issue 1

Issues

Volume 10 (2015)

Trefoil factor 3 as a marker of intestinal cell damage during sepsis

Jiří Žurek
  • University Children‘s Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno, 62500, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michal Kýr / Martin Vavřina
  • University Children‘s Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno, 62500, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michal Fedora
  • University Children‘s Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno, 62500, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-04-24 | DOI: https://doi.org/10.1515/med-2015-0020

Abstract

Objective: Gastrointestinal dysfunction or gut failure frequently occurs in seriously ill patients and can be responsible for multi-organ failure. Trefoil factor 3 (TFF3) was characterized for its role in reconstitution of an epithelial barrier after mucosal injury in the jejunum. The aims of our study was an analysis of TFF3 levels dynamics in patients with sepsis and the correlation of TFF3 with severity of sepsis and mortality.

Methods: Prospective observational study, a ten days evaluation period in children aged 0-19 years with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of TFF3 were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis.

Results: Analysis of dynamics revealed steady levels of TFF3 during the 10 day period evaluated. TFF3 levels could not differentiate between various septic conditions in patients until a marked organ dysfunction developed. Higher Area Under Curve was noticed between control group and patients with sepsis. We could not make any strong conclusions based on mortality model.

Conclusions: Levels of TFF3 are elevated in paediatric patients with sepsis through organ dysfunction.

Keywords: Trefoil factor; gut injury; sepsis; children; mortality

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About the article

Received: 2013-08-28

Accepted: 2014-12-11

Published Online: 2015-04-24


Citation Information: Open Medicine, Volume 10, Issue 1, ISSN (Online) 2391-5463, DOI: https://doi.org/10.1515/med-2015-0020.

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© Jiří Žurek et al. 2015 . This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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