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Open Medicine

formerly Central European Journal of Medicine

Editor-in-Chief: Darzynkiewicz, Zbigniew

IMPACT FACTOR 2018: 1.221

CiteScore 2018: 1.01

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Source Normalized Impact per Paper (SNIP) 2018: 0.479

ICV 2018: 156.09

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Volume 10, Issue 1


Volume 10 (2015)

Postprandial decrease in LDL-cholesterol in men with metabolic syndrome

Anna Skoczyńska
  • Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wrocław, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Barbara Turczyn
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Anna Wojakowska
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bogusława Kreczyńska
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marta Skoczyńska
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kamila Wojtas
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-02-03 | DOI: https://doi.org/10.1515/med-2015-0025


Background: In some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy). Methods: 36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apoli- poproteins A-I, B, and hsCRP immunoturbidimetrically. Results: The postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-choles- terol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy. Conclusion: In men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.

Keywords: Postprandial LDL-cholesterol; metabolic syn- drome; apoB/apoA ratio


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About the article

Received: 2013-10-20

Accepted: 2014-03-31

Published Online: 2015-02-03

Citation Information: Open Medicine, Volume 10, Issue 1, ISSN (Online) 2391-5463, DOI: https://doi.org/10.1515/med-2015-0025.

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© 2015 A. Skoczyńska et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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