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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access December 17, 2015

The role of 99mTc-MIBI SPECT-CT in reoperation therapy of persistent hyperparathyroidism patients

  • Lijie Yin EMAIL logo , Dandan Guo , Jie Liu and Jue Yan
From the journal Open Medicine

Abstract

To compare the role of 99mTc-MIBI SPECT-CT image and US in reoperation of persistent secondary hyperparathyroidism patients. A total of 8 persistent secondary hyperparathyroidism patients underwent parathyroidectomy. The sensitivity and accuracy of US and 99mTc-MIBI images before operation were determined. 9 of 14 surgical resection tissues from 8 persistent secondary hyperparathyroidism patients were confirmed to parathyroid hyperplasia. The results showed that the sensitivities were 77.8% and 100%, respectively, for US and 99mTc-MIBI SPECT-CT images. And the accuracies of US and 99mTc-MIBI dual time planar image and SPECT-CT were 50%, 78.6%, respectively. There was significantly difference between two procedures (P=0.021). The superior and inferior localization of glands were both detected by the ultrasound and scintigraphy. Two ectopic parathyroidism nodules were found by 99mTc- MIBI SPECT-CT imaging, while US provided no consistent findings. There was no significantly difference between two procedures (P=0.3). Although two cases of them were not confirmed by pathology, the iPTH of them (800 and 1429 respectively) were much higher than other four cases (<400) pg/ml. PTX is a safe and effective treatment for the patients with persistent SHPT. 99mTc-MIBI planar and SPECT-CT imaging may provide more helps for clinician’s localization the hyperparathyroidism glands accurately.

References

[1] Hamouda M., Ben Dhia N., Aloui S., et al., Surgical treatment of secondary hyperparathyroidism in patients with chronic renal failure, Nephrol. Ther., 2011, 7, 105-11010.1016/j.nephro.2010.10.003Search in Google Scholar PubMed

[2] Xiaowei W., Zhiyong C., Huagang Z.H.U., Progress in diagnosis and treatment of persistent and recurrent hyperparathyroidism, Anhui Medical and Pharmaceutical Journal, 2011, 15, 666-668Search in Google Scholar

[3] Li Y., Ling Z., Peng L.I.U., et al., Therapeutic evaluation of parathyroidectomy for 89 cases with refractory secondary hyperparathyroid-ism, Chinese Journal of Blood Purification, 2009, 8, 431-436Search in Google Scholar

[4] Clark O.H., Duh Q.Y., Kebebew E., Textbook of Endocrine Surgery, Second Edition, Philadelphia, Elsevier Saunders, 2005, 518Search in Google Scholar

[5] Kalantar-Zadeh K., Shah A., Duong U., et al., Kidney bone disease and mortality in CKD, revisiting the ro1e of vitamin D, calcimimetics, alkaline phosphatase and minerals, Kidney Int., 2010, 117, S10-2l10.1038/ki.2010.189Search in Google Scholar PubMed PubMed Central

[6] Ling Z., Wenbo W., Li Y., et al., Total parathyroidectomy with forearm autograft in the treatment of a patient with secondary hyperparathyroidism, Chinese Journal of Blood Purification, 2011,10, 277-282Search in Google Scholar

[7] Li Y., Zhan H., Ling Z., et al., Is autotransplantation needed for SPHT patients after undergoing the whole excision of parathyroid glands? Chinese Journal of Blood Purification, 2011, 10, 233-235Search in Google Scholar

[8] Chungui S., Zhiyong Y., Tianyan Z., The clinical value of ultrasonography in patients with secondary hyperparathyroidism performing maintenance hemodialysis, Chinese Medical Herald, 2011, 8, 87-88Search in Google Scholar

[9] Lishi Z., Xiaojian L., Ling Z., et al.. Value of dual-phase 99Tcm-MIBI scintigraphy and SPECT/CT in the localization diagnosis of secondary hyperparathyroidism, Chinese Journal of Blood Purification, 2011, 10, 242-245Search in Google Scholar

[10] Wakamatsu H., Noguchi S.,Yamashita H., et al., Technetium-99m- tetrofosmin for parathyroid scintigraphy: a direct comparison with (99m)Tc-MIBI, (201)T1, MRI and US, Eur. J. Nucl. Med., 2001, 28, 1817-182710.1007/s002590100627Search in Google Scholar PubMed

[11] Ling T., Rongfu W., Li H., et al., Clinical Value of Radionuclide Parathyroid Imaging in Hyperparathyroidism, Chinese Journal of Medical Imaging Technology, 2003, 19, 863-865Search in Google Scholar

[12] Binbin Z., Qian W., Yuan L., Parathyroid hormone testing and 99Tcm-MIBI imaging of hyperparathyroidism, Chinese Journal of Nuclear Medicine and Molecular Imaging, 2011, 31, 263-266Search in Google Scholar

[13] Haiming L., Yong G.U., Jun X., et al., Clinical effect of total parathyroidectomy with forearm autograft on uremic patientsSearch in Google Scholar

Received: 2015-7-11
Accepted: 2015-10-15
Published Online: 2015-12-17
Published in Print: 2015-1-1

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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