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Non-coding RNAs in Endocrinology

Ed. by Hardikar, Anandwardhan

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Emerging Science

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2300-4258
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MicroRNAs: emerging regulators for development of pancreatic islet lineages

Fang-Xu Jiang
  • Centre for Diabetes Research, Western Australian Institute for Medical Research, and Centre for Medical Research, The University of Western Australia, Perth 6000, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Grant Morahan
  • Centre for Diabetes Research, Western Australian Institute for Medical Research, and Centre for Medical Research, The University of Western Australia, Perth 6000, Australia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-07-26 | DOI: https://doi.org/10.2478/micrnado-2013-0002

Abstract

MicroRNAs belong to a family of small (-23 nt) non-coding RNAs that mediate posttranscriptional gene silencing. They are emerging as important new regulators of differentiation and development. Knowledge of their role in pancreas and islet development, may help in developing a regenerative therapy for diabetes mellitus, a metabolic disorder affecting hundreds of millions of people worldwide. In this minireview, we summarize the latest evidence of the role these new regulators play in islet lineage development, aiming to attract more research into this important developmental regulators.

Keywords: MicroRNAs; Islet progenitors; Differentiation

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About the article

Received: 2012-11-05

Accepted: 2012-11-28

Published Online: 2014-07-26

Published in Print: 2014-07-01


Citation Information: Non-coding RNAs in Endocrinology, Volume 1, Issue 1, ISSN (Online) 2300-4258, DOI: https://doi.org/10.2478/micrnado-2013-0002.

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© 2014. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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