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Bio-surface engineering with DNA scaffolds for theranostic applications

Xiwei Wang
  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wei Lai
  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tiantian Man
  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China
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  • De Gruyter OnlineGoogle Scholar
/ Xiangmeng Qu
  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Li Li
  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Arun Richard Chandrasekaran / Hao Pei
  • Corresponding author
  • Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P. R. China
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Published Online: 2018-05-17 | DOI: https://doi.org/10.1515/nanofab-2018-0001

Abstract

Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various “art-like” DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.

Keywords: DNA nanostructures; theranostic application; diagnostics; therapeutics; bio-surface programmable; biosensor

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About the article

Received: 2017-12-25

Accepted: 2018-03-12

Published Online: 2018-05-17


Citation Information: Nanofabrication, Volume 4, Issue 1, Pages 1–16, ISSN (Online) 2299-680X, DOI: https://doi.org/10.1515/nanofab-2018-0001.

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