Jump to ContentJump to Main Navigation
Show Summary Details
In This Section


Managing Editor: Sorger, Volker

6 Issues per year

IMPACT FACTOR 2016: 4.492

5-year IMPACT FACTOR: 5.723

In co-publication with Science Wise Publishing

Open Access
See all formats and pricing
In This Section

Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

Frank Vollmer
  • Corresponding author
  • Max Planck Institute for the Science of Light, Laboratory of Nanophotonics and Biosensing, G.Scharowsky Str. 1, 91058 Erlangen, Germany
  • Email:
/ Lan Yang
  • Corresponding author
  • Electrical and Systems Engineering Department, Washington University, St. Louis, MO 63130, USA
Published Online: 2012-12-06 | DOI: https://doi.org/10.1515/nanoph-2012-0021


Optical microcavities that confine light in high-Q resonance promise all of the capabilities required for a successful next-generation microsystem biodetection technology. Label-free detection down to single molecules as well as operation in aqueous environments can be integrated cost-effectively on microchips, together with other photonic components, as well as electronic ones. We provide a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection. We survey the most recent developments such as the use of mode splitting for self-referenced measurements, plasmonic nanoantennas for signal enhancements, the use of optical force for nanoparticle manipulation as well as the design of active devices for ultra-sensitive detection. Furthermore, we provide an outlook on the exciting capabilities of functionalized high-Q microcavities in the life sciences.

Keywords: biosensing; integrated photonics; microlasers; optical microcavities; optical trapping; plasmonics; optical resonator; nanoparticle detection

About the article

Corresponding author Edited by Shaya Fainman, UC San Diego, La Jolla, CA, USA

Received: 2012-07-25

Accepted: 2012-10-16

Published Online: 2012-12-06

Published in Print: 2012-12-01

Citation Information: Nanophotonics, ISSN (Online) 2192-8614, ISSN (Print) 2192-8606, DOI: https://doi.org/10.1515/nanoph-2012-0021. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Ann Britt Petermann, Arthur Varkentin, Bernhard Roth, Uwe Morgner, and Merve Meinhardt-Wollweber
Optics Express, 2016, Volume 24, Number 6, Page 6052
Hrishikesh Kelkar, Daqing Wang, Diego Martín-Cano, Björn Hoffmann, Silke Christiansen, Stephan Götzinger, and Vahid Sandoghdar
Physical Review Applied, 2015, Volume 4, Number 5
Fang-Jie Shu, Chang-Ling Zou, Şahin Kaya Özdemir, Lan Yang, and Guang-Can Guo
Optics Express, 2015, Volume 23, Number 23, Page 30067
Xu Yang, Şahin Kaya Özdemir, Bo Peng, Huzeyfe Yilmaz, Fu-Chuan Lei, Gui-Lu Long, and Lan Yang
Optics Express, 2015, Volume 23, Number 23, Page 29573
Yuanxian Zhang, Weidong Meng, Hongyue Yang, Yufei Chu, and Xiaoyun Pu
Optics Letters, 2015, Volume 40, Number 21, Page 5101
Jijun Feng and Ryoichi Akimoto
IEEE Photonics Technology Letters, 2015, Volume 27, Number 15, Page 1601
J. M. Ramírez, D. Navarro-Urrios, N. E. Capuj, Y. Berencén, A. Pitanti, B. Garrido, and A. Tredicucci
Scientific Reports, 2015, Volume 5, Page 14452
I. A. Grimaldi, G. Testa, and R. Bernini
RSC Adv., 2015, Volume 5, Number 86, Page 70156
Leilei Shi, Tao Zhu, Dongmei Huang, Min Liu, Ming Deng, and Wei Huang
Optics Letters, 2015, Volume 40, Number 16, Page 3770
Marcel Schubert, Anja Steude, Philipp Liehm, Nils M Kronenberg, Markus Karl, Elaine C. Campbell, Simon J. Powis, and Malte Gather
Nano Letters, 2015, Page 150717175233008
Nan Zhang, Shuai Liu, Kaiyang Wang, Zhiyuan Gu, Meng Li, Ningbo Yi, Shumin Xiao, and Qinghai Song
Scientific Reports, 2015, Volume 5, Page 11912
Matthias Mader, Jakob Reichel, Theodor W. Hänsch, and David Hunger
Nature Communications, 2015, Volume 6, Page 7249
Aurélien A. P. Trichet, Philip R. Dolan, David M. Coles, Gareth M. Hughes, and Jason M. Smith
Optics Express, 2015, Volume 23, Number 13, Page 17205
T. Reynolds, M. R. Henderson, A. François, N. Riesen, J. M. M. Hall, S. V. Afshar, S. J. Nicholls, and T. M. Monro
Optics Express, 2015, Volume 23, Number 13, Page 17067
Darius Urbonas, Armandas Balčytis, Martynas Gabalis, Konstantinas Vaškevičius, Greta Naujokaitė, Saulius Juodkazis, and Raimondas Petruškevičius
Optics Letters, 2015, Volume 40, Number 13, Page 2977
Uwe Bog, Falko Brinkmann, Sentayehu Fetene Wondimu, Tobias Wienhold, Sarah Kraemmer, Christian Koos, Heinz Kalt, Michael Hirtz, Harald Fuchs, Sebastian Koeber, and Timo Mappes
Advanced Science, 2015, Page n/a
Carlo Edoardo Campanella, Francesco De Leonardis, Lorenzo Mastronardi, Pietro Malara, Gianluca Gagliardi, and Vittorio M. N. Passaro
Optics Express, 2015, Volume 23, Number 11, Page 14301
Matthew R. Foreman, Jon D. Swaim, and Frank Vollmer
Advances in Optics and Photonics, 2015, Volume 7, Number 2, Page 168
Andreas W. Schell, Hideaki Takashima, Shunya Kamioka, Yasuko Oe, Masazumi Fujiwara, Oliver Benson, and Shigeki Takeuchi
Scientific Reports, 2015, Volume 5, Page 9619
Wenle Weng, James D. Anstie, and Andre N. Luiten
Physical Review Applied, 2015, Volume 3, Number 4
Jonathan M. M. Hall, V. Shahraam Afshar, Matthew R. Henderson, Alexandre François, Tess Reynolds, Nicolas Riesen, and Tanya M. Monro
Optics Express, 2015, Volume 23, Number 8, Page 9924
Kai Zang, Dengke Zhang, Yijie Huo, Xiaochi Chen, Ching-Ying Lu, Edward T. Fei, Theodore I. Kamins, Xue Feng, Yidong Huang, and James S. Harris
Applied Physics Letters, 2015, Volume 106, Number 10, Page 101111
Costa Nicolaou, Wah Tung Lau, Raanan Gad, Hooman Akhavan, Ryan Schilling, and Ofer Levi
Optics Express, 2013, Volume 21, Number 25, Page 31698
C. Doolin, P. Doolin, B. C. Lewis, and J. P. Davis
Applied Physics Letters, 2015, Volume 106, Number 8, Page 081104
Chang-Lei Guo, Kai-Jun Che, Guo-Qiang Gu, Guo-Xiong Cai, Zhi-Ping Cai, and Hui-Ying Xu
Applied Optics, 2015, Volume 54, Number 6, Page 1250
Jacob B. Khurgin
Nature Nanotechnology, 2015, Volume 10, Number 1, Page 2
I. A. Grimaldi, S. Berneschi, G. Testa, F. Baldini, G. Nunzi Conti, and R. Bernini
Applied Physics Letters, 2014, Volume 105, Number 23, Page 231114
Kerry A. Wilson, Craig A. Finch, Phillip Anderson, Frank Vollmer, and James J. Hickman
Biomaterials, 2015, Volume 38, Page 86
A. A. P. Trichet, J. Foster, N. E. Omori, D. James, P. R. Dolan, G. M. Hughes, C. Vallance, and J. M. Smith
Lab Chip, 2014, Volume 14, Number 21, Page 4244
J. M. Ward, N. Dhasmana, and S. Nic Chormaic
The European Physical Journal Special Topics, 2014, Volume 223, Number 10, Page 1917
M. Sumetsky
Optics Letters, 2014, Volume 39, Number 19, Page 5578
Martin D. Baaske, Matthew R. Foreman, and Frank Vollmer
Nature Nanotechnology, 2014, Volume 9, Number 11, Page 933
Y. Zhi and A. Meldrum
Applied Physics Letters, 2014, Volume 105, Number 3, Page 031902
Jiangxin Song, Jintian Lin, Jialei Tang, Yang Liao, Fei He, Zhaohui Wang, Lingling Qiao, Koji Sugioka, and Ya Cheng
Optics Express, 2014, Volume 22, Number 12, Page 14792
Yinlan Ruan, Keiron Boyd, Hong Ji, Alexandre Francois, Heike Ebendorff-Heidepriem, Jesper Munch, and Tanya M. Monro
Optics Express, 2014, Volume 22, Number 10, Page 11995
Jean-Raphaël Carrier, Maurice Boissinot, and Claudine Nì. Allen
American Journal of Physics, 2014, Volume 82, Number 5, Page 510
Michael Morrissey, Kieran Deasy, Mary Frawley, Ravi Kumar, Eugen Prel, Laura Russell, Viet Truong, and Síle Nic Chormaic
Sensors, 2013, Volume 13, Number 8, Page 10449
Matthew R. Foreman, Wei-Liang Jin, and Frank Vollmer
Optics Express, 2014, Volume 22, Number 5, Page 5491
E Özelci, M Aas, A Jonáš, and A Kiraz
Laser Physics Letters, 2014, Volume 11, Number 4, Page 045802
Hideaki Takashima, Kazutaka Kitajima, Yoshito Tanaka, Hideki Fujiwara, and Keiji Sasaki
Physical Review A, 2014, Volume 89, Number 2
Xingwang Zhang, Liying Liu, and Lei Xu
Applied Physics Letters, 2014, Volume 104, Number 3, Page 033703
Yu Chen, William S. Fegadolli, William M. Jones, Axel Scherer, and Mo Li
ACS Nano, 2014, Volume 8, Number 1, Page 522
Ming Li, Xiang Wu, Liying Liu, Xudong Fan, and Lei Xu
Analytical Chemistry, 2013, Volume 85, Number 19, Page 9328
Shoji Hachuda, Shota Otsuka, Shota Kita, Toshinari Isono, Michimasa Narimatsu, Keisuke Watanabe, Yoshio Goshima, and Toshihiko Baba
Optics Express, 2013, Volume 21, Number 10, Page 12815

Comments (0)

Please log in or register to comment.
Log in