Source of material
The compound was obtained by Knoevenagel condensation between equimolar amounts of 2-(benzo[d]thiazol-2-yl)acetonitrile and 3-pyridinecarboxaldehyde according to literature . The resulting mixtures were stirred for 18 minutes at room temperature using ethanol as solvent and catalytic amounts of triethylamine (TEA). The precipitates which formed were collected by filtration, washed with ethanol and dried, and then crystallized from ethanol giving the compound in yields of 66%; m.p. 155–157 °C; EI—MS (m/z): 263 (M+, 100), 226 (20), 210 (38). The 1H-NMR analysis of this derivative revealed a single olefinic proton at δ 8.51 associated with the formation of a single E-isomer. Crystals suitable for single-crystal X-ray diffraction were grown from solutions in ethanol.
H atoms were located in the difference Fourier map, but refined with fixed individual displacement parameters, using a riding mode with C—H distances of 0.93 Å with Uiso(H) values of 1.2Ueq(C).
The heteroaryl-acrylonitriles have emerged recently as a new family of acetylcholinesterase inhibitors (AChEIs) [1, 2]. In addition, this family of compounds have been proved for having prominent biological properties as antifungal, antitumor, and antibacterial activities [3–7], as well as applications for the design of dendrimers  and fluorescent probes for visualizing endogenous thiols in living cells [9, 10]. They have also been reported in the literature as versatile building-blocks for molecules with potential biological or pharmaceutical applications [11–17].
In the figure there are represented two molecules in the asymmetric unit, which are connected by non-classical C—H⋯N hydrogen bond interactions. The crystal structure is further stabilized by weak π−π stacking interactions with distance Cg1—Cg2i 3.80 Å (Cg1: C11/C16; Cg2i: C2/C7, symmetry code (i): 1−x, −y, 1−z). The main difference between both molecules is the dihedral angle formed by the benzothiazolyl fragment and the pyridine ring, which showed values of 4.97(6)° and 17.59(7)° for molecules A and B, respectively. The bond lengths and angles are in the expected ranges.
Dedicated to the memory of Professor Luis Astudillo Saavedra for his scientific career, support and fraternity. Thanks the Doctoral Program of Applied Sciences at Universidad de Talca, as well as the Chilean International Cooperation Agency (AGCI) and CONICYT-Chile for a doctoral fellowship. M.G. and L.A. thank PIEI QUIM-BIO-Utalca project 1100481, J.C. thanks FONDECYT project 1130141. I.B. thank to CONICYT, FONDEQUIP program/single crystal diffractometer/EQM130021. The authors thank the responsible editor for supplying the figure.
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About the article
Published Online: 2016-01-13
Published in Print: 2016-03-01
Citation Information: Zeitschrift für Kristallographie - New Crystal Structures, Volume 231, Issue 1, Pages 171–173, ISSN (Online) 2197-4578, ISSN (Print) 1433-7266, DOI: https://doi.org/10.1515/ncrs-2015-0073.
©2016 Pedro De-La-Torre et al., published by De Gruyter.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0