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Nanotechnology Reviews

Editor-in-Chief: Hui, David

Managing Editor: Skoryna, Juliusz


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Volume 2, Issue 3

Issues

Metal nanoantimicrobials for textile applications

Lorena Carla Giannossa / Daniela Longano / Nicoletta Ditaranto / Maria Angela Nitti
  • Department of Physics “M. Merlin”, University of Bari “Aldo Moro”, Via Amendola 173, 70126 Bari, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Federica Paladini
  • Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mauro Pollini
  • Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mahendra Rai
  • Department of Biotechnology, SGB Amravati University, Amravati, 444 602 Maharashtra, India
  • Laboratório de Química Biológica, Instituto de Química, Unicamp-Cidade Universitária “Zefferino Vaz”, Barão Geraldo-CEP 13083-970, 6150 Campinas SP, Brasil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alessandro Sannino
  • Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Antonio Valentini
  • Department of Physics “M. Merlin”, University of Bari “Aldo Moro”, Via Amendola 173, 70126 Bari, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nicola Cioffi
Published Online: 2013-04-24 | DOI: https://doi.org/10.1515/ntrev-2013-0004

Abstract

Research on the nanomaterials containing one or more transition metals is growing tremendously, thanks to the large number of preparation processes available and to the novel applications that can be envisaged in several fields. This review presents an overview of the selected studies in the field of antimicrobial textiles, employing bioactive nanophases of elements/compounds such as silver, copper, or zinc oxide. In addition, the history of use of these antimicrobials and their mechanism of action are shortly reported. Finally, a short description is provided of the deposition/preparation methods, which are being used in the authors’ labs for the development of the textiles modified by the novel nanoantimicrobials.

Keywords: copper; nanoantimicrobial; textile; silver; zinc oxide

1 Introduction

In the last decades, several research and industrial efforts have been devoted to the development of new products for enhancing the quality of human life. The textile production, one of the most relevant and ever-advancing industrial field around the world, is not an exception. In particular, with a rising awareness in personal health and hygiene, the textiles with antimicrobial properties are becoming an appealing field for both the manufacturers and researchers [1–26].

The antimicrobial agents are generally used to avoid three undesirable effects in textiles [10]. The first is regarding the characteristic degradation phenomena of fabrics, like coloring, staining, and deterioration of the fibers [27–29]. The second one is the production of unpleasant odor [30–32], and the last one is the increase of potential health risks [1, 33–36]. Besides, the polymeric and especially natural fibers have no resistance against microorganisms and their metabolites, as well as they are most commonly responsive to accumulation, multiplication, and proliferation of the microorganisms [30–32, 34, 37, 38]. When in contact with the human body, the textiles offer an ideal environment for microbial growth because of their large surface area, ability to retain oxygen, moisture and warmth, suitable temperature and humidity, as well as nutrients from spillages and body exudates [39]. Therefore, various antibacterial finishing and disinfection techniques are being developed for all the types of textiles: from hospital environment (medical clothes, protective garments, wound bandages, etc.) to everyday household and clothing.

In general, the antimicrobial properties can be imparted to the textile materials by chemically or physically incorporated functional agents onto the fibers or fabrics. Almost every class of chemical compound has been tested to confer the antibacterial activity to the textiles. The chemical agents in use for controlling the microorganisms ranged from the very simple substances such as halogen ions to very complex compounds [40–42]. In the last decades, using many antimicrobial agents without a tight control over their bioactivity has been stopped because of their possible undesired harmful or toxic effects [10].

Differently from some organic compounds, which have also been employed in the textile finishing processes such as the antibacterial agents, the metal nanoparticles (NPs) represent a good alternative, providing new bioactivity mechanisms and allowing the multifunctional modification of the textiles. The nanomaterials range from the nanometals, such as silver and copper NPs, to the metal oxides, such as titanium or zinc oxides [43], to the carbon nanotubes (CNT) and clays.

The current textile products have been progressed so much that many of them are designed to inhibit the microorganisms’ growth and proliferation, thus, contributing to prevent the disease transmission; moreover, these modifications are tailored to be effective for a long-term period. The cutting edge in this field is the development of efficient, nontoxic, durable, and cost-effective antimicrobial finishing textiles with increased applications in medicine, health care, and in the development of hygienic products as well as protective textile materials [43–45].

The antimicrobial textiles exclusively employing drugs or other organic/molecular biocides are not reviewed in this paper, which is, on the contrary, focused on the current research on innovative textile fibers modified with metal nanoantimicrobials. These novel products possess good antimicrobial properties due to the presence of the bioactive metals such as silver, copper, and zinc in the forms of nanophases containing ions, oxides, or complexes. The extensive citation of the studies related to the bioactivity mechanisms involving the aforementioned ions and metals is provided as well. This also because ionic release is at the basis of the important bioactivity mechanisms of the mentioned nanoantimicrobials. Finally, a brief mention of the novel textile modification methods developed in the authors’ laboratories is provided.

2 History and antimicrobial mechanisms of silver, copper, and zinc oxide

Some bioactive elements and oxides, such as Ag, Cu, and ZnO, either as such or when they are dissolved in the form of ions or complexes, possess wide-spectra antimicrobial properties. Indeed, these antimicrobial properties are known since ancient times. Therefore, a short description of the uses of these elements as antimicrobial agents is presented in the next paragraphs to understand why silver, copper, and zinc have become the interesting agents for disinfecting the textiles. The ability of an organism to accumulate antimicrobial metal species from the environment is critical for its growth and survival. The mechanisms of action of these elements (as well as the resulting nanophases) have not been understood completely; however, some information about the metal-microorganism interactions are reported in the following subsections.

2.1 Silver: history and mechanisms of action

Silver and its antimicrobial properties are known since antiquity. For thousands of years, silver has been used as a healing and antibacterial agent by the civilizations throughout the world. Its medical, preservative, and restorative powers can be traced back to the ancient Greek and Roman Empires. Before the development of modern pharmaceuticals, silver was employed as a germicide and antibiotic. The Greeks used silver for water purification, and Pliny the Elder, the famous Roman physician, reported on the properties of silver in his encyclopedia (79 AD) [46]. The use of silver is mentioned in the ancient Egyptian writings. Hippocrates, the father of modern medicine, believed silver powders to have a beneficial healing for ulcer [47]. Since the 19th century, many studies were carried out, and many applications of silver were employed in the different fields of medical research [48]. In Germany (1884), Carl Siegmund Franz Credé introduced an eye prophylaxis to prevent ocular infection by using silver nitrate solution on neonates [49]. In the 1920s, colloidal silver was accepted by the US Food and Drug Administration (FDA) as being effective for wound management [50], and through the first half of the 20th century, it was used to control infections in burn wounds [49].

A variety of mechanisms may be involved in the antimicrobial activity of silver toward several microorganisms. Some of the commonly accepted mechanisms include the silver-amino acid interaction, silver-DNA interaction, generation of reactive oxidative species (ROS), and direct cell membrane damages [10, 29, 51–65].

First of all, the interaction between the metal ions and thiol groups in the proteins or enzymes of the microorganisms leads to the inhibition of most of their biological functions [66–70].

Feng et al. [71] have reported the antibacterial mechanism of Ag+ on Escherichia coli and Staphylococcus aureus bacteria showing that after silver treatment, electron dense granules were generated by cell self-defense mechanism to protect the DNA. This has been confirmed in another work by Yang et al. [72].

Silver ions can also generate an excess of ROS which are extremely deleterious to the cells, causing damages to the lipids or DNA. It has been shown that E. coli have two proteins as ROS-sensing systems: SoxR and OxyR [73]. When exposed to the superoxide or nitric oxide radicals, SoxR protein induces a single-gene soxS, and by monitoring the soxS induction in the reporter strains, the ROS level in the solution can be determined. Therefore, the generation of the ROS is a plausible biocidal pathway and also suggests that the antibacterial mechanisms of silver ions are a combination of ROS generation and silver-thiol interactions [73].

Bard and coworkers [74] have reported the inhibition of respiration of E. coli cells treated by silver ions. The mechanism of action involves silver ions that are able to make the cell membrane permeable to protons; therefore, to compensate the loss of proton gradient, the acceleration of respiratory process is triggered, attempting to expel more protons to restore the proton gradient. This uncontrolled process generates the superoxide or hydroxyl radicals, which are extremely harmful to the cells.

Finally, the direct damage to the cell membranes caused by the silver nanomaterials has been reported recently by Morones et al. [75]. The detailed mechanism of the cell membrane penetration and accumulation of the silver NPs is not fully understood. One hypothesis is that the accumulation is caused by the electrostatic attraction between the negatively charged bacterial surfaces and positively charged silver NPs [76]. However, this does not explain why the negatively charged silver NPs are able to adhere and enter the bacterial cells. Another possibility is that the process is initiated by silver-thiol group interaction on the cell surface, as it is hypothesized in a recent publication [77].

A further explanation for the cell membrane damage is proposed for the Gram-negative bacteria such as E. coli. The Gram-negative bacteria possess an external membrane outside the peptidoglycan layer, which is lacking in Gram-positive bacteria. It was previously found that the chelating agent EDTA can cause the depletion of Ca2+ and Mg2+ ions, resulting in pits and holes in the outer membranes due to the release of the lipopolysaccharide (LPS) molecules [78]. Sondi et al. [79] also observed a similar phenomenon by treating E. coli bacteria with silver NPs. They showed SEM images clearly highlighting the presence of many holes in the cell membranes of the silver-treated E. coli. It was also hypothesized that silver may generate pits and holes in the cell membrane by the aforementioned LPS-release mechanism [79].

2.2 Copper: history and mechanisms of action

The disinfecting power of copper was discovered by the ancient Greeks. They had easy access to copper as this metal was readily available on the island of Kypros (Cyprus) from which the Latin name for copper, cuprum, is derived. They purified drinking water with copper and prescribed it for diseases affecting the lungs. Copper was used by the ancient Egyptians in order to sterilize wounds and drinking water. During the reign of Tiberius (14 to 37 AD), copper and its derivatives had been firmly established as an important drug in the medical practitioner’s pharmacopoeia. The Aztecs also used copper for medical purposes, while in Persia and India, copper was applied to treat numerous infections [80, 81]. The Celts produced whisky in copper vessels in Scotland, and copper strips were nailed to the ship’s hulls by the early Phoenicians to inhibit fouling. In the western world (18th century), copper was employed for the treatment of mental disorders and pulmonary diseases. In the 19th century, the first observation of the copper’s role in the immune system was published in 1867 when it was reported that, during the cholera epidemics in Paris, copper workers were immune to the disease. The early American pioneers put silver and copper coins in large wooden water casks to disinfect the drinking water like the Japanese soldiers that, during the World War II, used to place pieces of copper in their water bottles to prevent dysentery. One of the first surveys on the historic use of copper medicinal substances was proposed by J. R. J. Sorenson [82]. The same author demonstrated that the copper complexes have a therapeutic efficacy in the treatment of inflammatory diseases using doses that are nontoxic [83, 84]. Copper sulfate is highly prized by some inhabitants of Africa and Asia for therapeutic sores and skin diseases. Finally, NASA first designed an ionization copper-silver sterilizing system for its Apollo flights [82, 85].

Nowadays, copper is used as a water purifier and as an antibacterial and antifouling agent [33]. Introducing copper into clothing, bedding, and other articles would provide them with biocidal properties [86]. However, copper is also an essential element required by all the living organisms as it is an important cofactor for a variety of enzymes that are required for the essential biochemical processes such as cytochrome c oxidase, Cu-Zn superoxide dismutase, lysil oxidase, and dopamine-ß-hydroxylase [87].

Several mechanisms for the biocidal activity of copper have been proposed. These include the production of hydroxyl radicals, which cause cellular damage such as the oxidation of proteins, cleavage of DNA and RNA molecules, and membrane damage due to lipid peroxidation [85].

The copper’s initial site of action is thought to be at the plasma membrane [85, 88–90]. It has been shown that the exposure of fungi and yeast to the extremely high copper concentrations can lead to a rapid decline in membrane integrity. This generally manifests itself as leakage of mobile cellular solutes, such as potassium ions, and cell death. Similar effects reported in higher organisms have now been largely attributed to the redox-active nature of copper and its ability to catalyze the generation of the free radicals that promote membrane lipid peroxidation [91–93].

After the completion of its genome sequence, Saccharomyces cerevisiae yeast has become a model organism for elucidating the mechanism and regulation of copper homeostasis [94]. The genetic screenings have identified the genes that are responsible for Cu uptake under nutritional conditions, as well as for Cu distribution to the appropriate subcellular compartments and detoxification processes that are activated under toxic conditions, when Cu ions are present in excess [84]. In S. cerevisiae, copper is a cofactor of Cu/Zn-superoxide dismutase, cytochrome c oxidase (Cyt Ox), and of the FET3 and FET5 multicopper oxidases that are required for the several essential biochemical processes.

The copper uptake in this model microorganism is mediated by two separate systems: the so-called high-affinity system is involved under conditions of Cu nutritional depletion, while the low-affinity system operates in the presence of an excess of Cu ions, under toxic conditions [84, 94, 95].

The high-affinity copper uptake system involves two plasma membrane reductase enzymes, named Fre1 and Fre2, capable of inducing reduction of Cu2+ to Cu1+ and two high-affinity transporter proteins, Ctr1 and Ctr3, which operate on cuprous ions [84, 94, 96, 97].

The FRE1, FRE7, CTR1, and CTR3 species are downregulated by the transcriptional factor Mac1 [98–100] that is localized within the nucleus, apart from Cu1+ concentration in the cell, and is characterized by the cystein-rich carboxyterminal moieties with transactivation capability. Interestingly, Mac1 itself behaves as a Cu sensor, as its functioning may be repressed when Cu binds to its activation domain [94, 98]. The excess of Cu2+ ions induces the expression of genes that encode the proteins with a protective role, such as metallothioneins Cup1, Crs5, and superoxide dismutase Sod1. The expressions of CUP1, CRS5, and SOD1 genes are activated by the transcription factor Ace1 [101].

The protein Ace1 cooperatively binds Cu1+ to form a tetra-Cu cluster through the specific cysteine residues within the amino-terminal DNA binding domain [84, 101, 102]. Copper binding leads to a conformational change in this domain resulting in the specific binding of Ace1 to the metal response elements (MREs) 5′-TCY(4-6)GCTG-3′ on the gene promoters involved in the copper detoxification and protection against oxidative damage [84, 103].

Three low-molecular-weight proteins have been identified, Cu-chaperone Atx1, Cox17, and Lys7, that are essential for the intracellular delivering of the Cu1+ ions to the cellular compartments. At least, one additional chaperone is expected to direct the Cu1+ ions to the nucleus for the regulation of Mac1 and Ace1 activities. These proteins bind copper after it enters the cell and subsequently deliver it to the corresponding recipient proteins. Atx1 is a small protein containing one metal-binding site and is the specific copper chaperone asked for copper delivering to the Ccc2 P-type ATPase in a late Golgi vesicle for the incorporation into Fet3 [95, 104, 105]. Cox17 is the copper chaperone that delivers copper to the mitochondria for Cyt Ox [106], while Lys7 is required to incorporate copper into Sod1 [107].

2.3 Zinc oxide: history and mechanisms of action

The first practice of zinc oxide is hardly traceable. Several zinc compounds were used by the early humans in various processed and unprocessed forms, but their exact composition is uncertain. Probably, it was used as a comfort for the eyes and wounds in India (500 BC or before) [108]. Zinc oxide cream is also mentioned by the Greek physician Dioscorides (1st century AD) [109]. Avicenna has introduced it in “The Canon of Medicine” (1025 AD), as a preferred treatment for a selection of skin conditions. It is still widely used to treat skin harms in products like baby powder and creams.

To the best of the authors’ knowledge, the efficiency of ZnO NP in imparting an antibacterial effect to the fabric is not yet well established, although it is known to strongly resist microorganisms [110–112]. The ZnO NPs are currently being investigated as an antibacterial agent both against the Gram-negative microorganism, such as E. coli, and Gram-positive microorganism such as S. aureus in the microscale and nanoscale formulations [113]. An important aspect of the use of ZnO as an antibacterial agent is the requirement that the particles are not toxic to the human cells [64, 114, 115].

Although the exact mechanism has not yet been clearly elucidated, the suggested mechanisms include the role of the ROS generated on the surface of the particle [113, 116–119], zinc ions release [120], membrane dysfunction [120, 121], and NP internalization [122]. The zinc ion sensors and regulatory mechanisms that control homeostasis in S. cerevisiae are similar to those described in the case of copper [95].

3 Textile fibers modified with metal nanostructures

The smart and multifunctional textiles are one of the most promising fields, responding to the ever-growing demand for high-technology goods. The development of the novel antimicrobial textiles is receiving great impulse, due to the demand for increased hygienic conditions and for specific devices contributing to prevent the spread of pandemic diseases. Many commercial antibacterial textiles have been, so far, based on the molecular active agents, such as antibiotics, disinfectants, etc. [10, 123, 124].

In the following, we will focus on the use of the most important inorganic nanoantimicrobials (namely, Ag, Cu, ZnO) for such an application.

The different synthesis routes to modify the textiles are reviewed in the following subsections and classified as a function of the fiber composition (e.g., natural or synthetic).

3.1 Silver modified textile fibers

As the antimicrobial spectrum of silver is exceptionally broad against fungi [125], viruses [126–128], and bacteria [129] as well as the resistance of the pathogenic bacteria vs. many antibiotics is increasing, the growing interest in nanotechnologies and nanosized materials have led to a renewed interest into the silver-modified goods, mainly based on the AgNPs, for many applications [130], such as coatings for medical devices or textile [131–133], silver-coated textile fabrics [134], water sanitization [135], and so on. Consequently, various methods, depending on the particular active agent and fiber type, have been studied to give antimicrobial activity to the textiles.

3.2 Natural fibers

Among the natural fibers, the cotton textile was often selected for silver deposition because it represents a suitable substrate for both the common and medical clothing. For example, a method particularly indicated for the hospital uniforms and wound dressings has been studied by Gittard et al. [136] using a supercritical carbon dioxide solvent, which may be used to produce the cotton fiber textiles with uniform silver NP coatings.

The polymer-silver nanocomposite-modified cotton fabrics were prepared by in situ chemical oxidative polymerization using pyrrole and silver nitrate by Babu et al. [137]. In the proposed redox reaction, the silver ions oxidize the pyrrole monomer and undergo reduction. The antimicrobial activity of the Ag/polypyrrole-modified fabrics was tested against S. aureus and E. coli.

Another method for the cotton modification is the sol-gel technique for preparing the bioactive materials for biomedical applications [138]. The sol-gel coating of the cellulose fibers with antimicrobial and repellent properties have been also investigated by Tomšič et al.: multifunctional, water and oil repellent, and antimicrobial finishes for the cotton fibers were prepared from a commercially available fluoroalkyl functional water-born siloxane, nanosized silver and a reactive organic-inorganic binder. Two different procedures were used and physical as well as antibacterial tests were carried out [139].

Nanosilver oxide (nano-Ag-oxide) was in situ synthesized and deposited into cotton gauze fabrics by the reduction of silver nitrate solutions by Gouda [140]. The antibacterial activity of the prepared samples was evaluated using a reduction rate% in the bacterial count against Salmonella typhimurium and S. aureus, while antifungal activity was evaluated according to the clear inhibition zone diameter against Candida albicans and Aspergillus flavus. All the samples were durable toward washing and bioactive even after 30 laundering wash cycles.

The electron beam radiation was applied to synthesize the silver nanostructures in the cotton fibers by Zang et al. [141]. Investigations of the influence of the initial silver salt concentration on the size and distribution of the obtained silver nanostructures were carried out. The antibacterial activity of the Ag-cotton nanocomposites was evaluated as well.

In another paper, the cotton fabric was exposed to laser at different energy levels, and then, the silver NPs were coated on untreated and laser-treated cotton fabrics to determine the antibacterial activity [142].

The antimicrobial coatings for the textile based on AgCl in a silica matrix on cotton fabric have been developed by Tomšič et al. [143]. Also, the influence of the antimicrobial activity of the two contemporary finishes was studied by the same research group [144], specifically, a dispersion of colloidal silver and 3-(trimet hoxysilyl)-propyldimethyloctadecyl ammonium chloride (Si -QAC), on the degree of biodeterioration of 100% cotton and cotton/polyester hybrid fabric. Ag was chosen as the release agent, while Si-QAC was used as the biobarrier-forming agent. The Ag agent can efficiently inhibit the biodeterioration of the cellulose fibers in the cotton and cotton/polyester fabrics, while the antimicrobial activity of Si-QAC was unsatisfying.

Tang and coworkers reported the combining of the silica and silver NPs on the surface of the wool fabrics [145]. The treated fibers with the silica and silver NPs showed a marked antibacterial activity because of the presence of the silver NPs.

The silver chloride nanocrystals have been synthesized on the silk fibers by sequential dipping in AgNO3 and NaCl, pointing out the antibacterial properties of the resulting material [146]. The antibacterial efficiency of Ag/SiO2 grafted on wool has been investigated by Wang et al. [147].

Nanosilver colloidal solution having the Ag/S complex has also been used by Ki et al. [148] for the functionalization of wool. Park et al. [149] developed an antimicrobial active robust metal-cellulose nanohybrid by the covalent assembly of the metal NPs on the cellulose fabric using a simple impregnation of the thiol-modified cellulose fabric in the colloidal silver NP solutions. This robust covalent linkage between the NPs and the fabric leads to a remarkable suppression of the release of the metal NPs from the fabric. In addition, the metal-cellulose nanohybrids showed a high antimicrobial activity in excess of 99.9% growth inhibition of the microorganism.

The silver/sodium carboxymethyl cotton dressing has been designed for burn wound bandages [150]. Nischala et al. [151] synthesized the silica-silver core-shell particles by the one-pot chemical method. The optimum density of the Ag NPs was found as a compromise between the needs of obtaining a good antibacterial activity and suppressing the Ag-NP surface plasmon resonance (responsible for the color alterations induced by the core-shell particle on the textile substrate).

In addition to the most common methods, sonochemical synthesis was proposed by Perelshtein [17] and Hadad [152] for preparing the natural or synthetic fabrics and wool fibers, respectively.

The impregnation methods have been used by Zhang et al. to treat the cotton fabric with silver nanocolloids. In this case, the antimicrobial activity was maintained after being exposed to 20 consecutive home laundering conditions [26]. The same method was used by Kim et al. [153], soaking the cotton fabrics into the silver colloid/3-MPTMS solution. These treated fabrics were tested for washing fastness and showed reasonable and relatively enhanced durability than the pad-dry-cure process, showing also an excellent antimicrobial performance.

Hebeish et al. have prepared the nanosilver colloidal solutions with a new copolymer, β-cyclodextrin grafted with polyacrylic acid using potassium persulfate as the initiator. The silver NP colloidal solutions were applied to the cotton fabric, showing excellent and durable antibacterial properties [154]. Also, Hebeish [155] showed the preparation of the AgNP solution using the environmental benign polymer (hydroxypropyl starch), which plays an important dual rule as both the reducing agent for Ag and stabilizer for the aqueous AgNPs. In addition, this kind of treatment was proposed as a safe, cost-effective, and environmental-friendly process in the fabrication of the antibacterial finishing and textiles.

A new approach to color and functionalize the conventional textile materials has been recently proposed by Tang et al. [156] assembling the anisotropic silver NPs on the wool fibers by the electrostatic interaction between the wool fibers and silver NPs. The modified wool fabrics exhibited brilliant colors due to the localized surface plasmon resonance (LSPR) properties of the silver NPs and antibacterial properties (see Figure 1). The surface plasmon resonance effect of silver has been used to color the merino wool fibers as well as impart the antimicrobial and antistatic properties by Kelly and Johnson [157]. The simultaneous antimicrobial properties and dyeing of the wool yarns were also achieved by Rad et al. [158], using a colloidal nanosilver solution and acid dye through an exhaustion method. The influence of the reactive dyes with massive chromogene and nanosilver on ultraviolet protective factor values of lightweight cotton fabrics was also investigated [159].

Coloration of wool fiber by using different silver NPs: (A) nanoprism I, (B) nanodisk I, and (C) nanodisk II. Reprinted from J. Colloidal Interface Sci., 2011, vol. 356, Tang B, Wang J, Xu S, Afrin T, Xu W, Sun L, Wang X, Application of anisotropic silver nanoparticles: multifunctionalization of wool fabric, pages 513–518. Copyright (2011), with permission from Elsevier.
Figure 1

Coloration of wool fiber by using different silver NPs: (A) nanoprism I, (B) nanodisk I, and (C) nanodisk II. Reprinted from J. Colloidal Interface Sci., 2011, vol. 356, Tang B, Wang J, Xu S, Afrin T, Xu W, Sun L, Wang X, Application of anisotropic silver nanoparticles: multifunctionalization of wool fabric, pages 513–518. Copyright (2011), with permission from Elsevier.

A novel method was introduced by Hosseinkhani et al. [160] in the textile processing to modify the coarse wool fineness along with the synthesis of nanosilver. Two different reducing agents with various concentrations were employed with different concentrations of the silver nitrate solutions. Further, the antibacterial properties of the fine wool were confirmed through testing with S. aureus and E. coli.

In a study by Sannino and coworkers [161], an innovative technique for the deposition of the nanosilver antibacterial coating on the woolen fiber was described. In particular, the fabrics woven with the different percentages of the silver-treated fibers were compared. The optimal mixing ratios, preserving the antibacterial activity and optimizing the cost-effectiveness of the final product were proposed. A very intense antibacterial activity against E. coli was found, even for the samples modified with a relatively low silver content.

El-Rafie et al. prepared the silver NPs colloid by making use of the biomass filtrate of the fungus Fusarium solani. The finishing formulation containing as low as 54 ppm of the nanosilver particles were prepared and applied to the cotton fabrics with and without a binder [162].

A “green process” using the natural extracts of Eucalyptus citriodora and Ficus bengalensis has been studied by Ravindra et al. The results showed an excellent antibacterial activity by the incorporation of 2% leaf extracts on the cotton fibers even after several washings, indicating their usage in medical and infection-prevention applications [163]. Another ecological and viable approach for the in situ forming of AgNPs on the cotton fabrics has been used lately by El-Shishtawy et al., who employed silver nitrate, cetyl trimethyl ammonium bromide, Triton X-100, glucose, and sodium hydroxide. The presence of a low-coating level of nanosilver was shown to be enough for producing an excellent and durable antimicrobial effect in the cotton fabrics [164]. The natural, biocompatible, and biodegradable polysaccharide chitosan continues to be used, thanks to its excellent chelating property. The silver NP-loaded chitosan-attached cotton fabric exhibits an excellent antibacterial action against the model bacteria E. coli [165]. A biological method based on the extracellular reduction induced by Fusarium oxysporum was proposed by Durán et al. [166] to synthesize the silver NPs and cotton fabrics incorporated with these silver NPs that exhibited an antibacterial activity against S. aureus.

Falletta et al. have functionalized cotton, wool, and polyester samples in order to obtain the antimicrobial textiles for the biomedical applications. They synthesized silver-poly(acrylate) clusters in water by the reduction of AgNO3 in the presence of poly(acrylates) of the different molecular weights through two different methods, NaBH4 reduction and UV exposure [167].

Also, the plasma coatings can be used as permanent hydrophilic treatment or for substrate-independent dyeing when deposited on the textile fabrics. For instance, Hegemann et al. [168] studied plasma polymerization of acetylene mixed with ammonia. Using plasma cosputtering of a silver target, the Ag nanoparticles could be in situ embedded within the growing plasma polymer yielding a well-defined size and distribution of the nanoparticles at the coating surface.

In addition, the possibility to combine the antimicrobial treatment of the silver NPs with the conventional finishing processes has been studied by Khoddami et al. [169]. Fixapret® ECO as a crosslinking agent and Cellofix® ME as a resin former have been used in anticrease finishing of the cotton fabric. The results showed that the treated samples by the pad-dry method have the best antibacterial effect, but washing and abrasion fastness were not at the acceptable level. Subsequently, they concluded that the antibacterial finishing method should be selected according to the end uses.

In a paper by Aly and coworkers [170], the multifinishing treatment of the cotton fabrics was carried out using the core-shell NPs that consist of the silver NPs as the core and chitosan-O-methoxy polyethylene glycol as the shell. The synthesized core-shell NP was applied to the cotton fabrics using the conventional pad-dry-cure method. The treated fabrics, at an optimum condition of 1% core shell NPs, 5% citric acid, drying at 80°C, and curing at 160°C for 2 min, showed an excellent antibacterial activity against E. coli and S. aureus, even after 20 washing cycles.

A pad-dry-cure process to obtain the treated fabrics was also carried out by Koparal and coworkers [171]. In this work, an antibacterial finishing agent containing calcium phosphate-based silver-doped powder was developed for the functionalization of the textiles and applied to 100% cotton and 100% polyester-knitted fabric samples. First, the silver-doped antibacterial powder was synthesized by using a wet chemical method; then, a size reduction process was applied for reducing the particle size from the micron size to the submicron scale. The treated fabrics were washed 20 times, and the antibacterial efficiency was evaluated according to the JIS-L 1902:2002 method against E. coli.

Mejía et al. [172] used magnetron sputtering to produce the cotton-Ag composites. A very peculiar case of the study is Abbasi et al.’s work [173], where the silver NPs have been used on the ancient textile to save it from demolition, decay, and damage.

Khalil-Abad and Yazdanshenas [174] and Xue et al. [175] have both studied the methods to prepare the superhydrophobic and antibacterial cotton textiles with a potential wide variety of biomedical and general use applications.

Sastri et al. [176] synthesized the silver NPs chemically by the wet reduction method and biologically by using the neem (Azadirachta indica) leaves. The coating of the socks fabrics (nylon and cotton) was carried out by exposing these fabrics to the prepared NP solutions on a gyratory shaker overnight. The antimicrobial activity of both the Ag-NP samples was carried out by performing minimum inhibitory concentration (MIC) and disc diffusion test against Sarcina lutea, Klebsiella pneumoniae, Pseudomonas aeruginosa, S. aureus, and Candida albicans.

3.2.1 Synthetic fibers

For the synthetic fibers, the antimicrobial active agents can be incorporated into the polymer prior to the extrusion or blended into the fibers during their formation and during the melt spinning. There are numerous ways by which the antimicrobial properties can be accomplished in the textiles: the incorporation of the volatile and nonvolatile antimicrobial agents directly into the fibers, coating or adsorbing the antimicrobials onto the fiber surfaces, immobilization of the antimicrobials to the fibers by the ion or covalent linkages, and the use of fibers that are inherently antimicrobial [177].

The silver NPs are used on the synthetic textiles too: Dubas et al. immobilized them on the nylon (and silk) fibers, using the layer-by-layer deposition method and obtaining the colored thin film with the antimicrobial properties [178].

Very recently, a facile procedure for binding the silver NPs on the polyester fabrics was reported by Xu et al. [179]. In this paper, the multifunctional polymer films were first formed through the simple dip-coating of the polyester fabrics in an aqueous solution of dopamine. Then, the silver NPs were in situ generated on the surface of the dopamine-modified polyester fabrics in an aqueous solution of silver nitrate, at room temperature. The resulting fabrics loaded with the silver NPs showed a durable antibacterial activity.

The use of Si was studied by Mahltig with Textor [180] and Fisher [181] too: the SiO2 coatings and inorganic/organic polymer hybrid coatings were applied onto the textiles on the synthetic fibers (polyamide and viscose). Silver was used for antimicrobial functionalization, and it was shown that the Ag release and the subsequent biocidal effect could be controlled by changing the metal content. To produce the commercial silver-coated nylon fabrics, 12% by weight of silver was added during manufacturing by an electroless plating process [182], and the antimicrobial capability of the nylon substrates coated with metallic silver has been checked against P. aeruginosa, S. aureus and C. albicans [183]. Magnetron sputtering has been also used to produce the silver-coated polyester fiber by Jiang et al. [184, 185].

Abbasi with Azadbakht reported on the novel synthesis of the acrylic fibers containing the Ag NPs under ultrasound irradiation [186]. The textile containing the NPs was successfully tested for their antibacterial efficacy against E. coli and S. aureus.

Perelshtein et al. described a process carried out by ultrasound radiation in a one-step reaction procedure to obtain both, synthetic (nylon and polyester) and natural (cotton), textiles with the antibacterial properties [17]. Besides, Ilić et al. [187] have described the antifungal efficiency of the pretreated polyester and polyamide fabrics treated with the Ag nanoparticles.

The durable antibacterial Ag/polyacrylonitrile hybrid nanofibers were prepared by the atmospheric plasma treatment and electrospinning by Shi et al. [188]. The hybrid nanofibers exhibited a slow and long-lasting silver ion release, which provided a robust antibacterial activity.

The highly hydrophilic fibers loaded with silver NPs were synthesized by an alternative approach, the electrospinning method [189]. First, poly (acrylic acid) and beta-cyclodextrin submicron fibers were electrospun; then, the silver ions were loaded into the fibers and reduced to silver NPs in situ (see Figure 2). These fiber mats show 99.99% of the killing efficiency, which is very attractive for the applications like wound healing and skin regeneration processes. To the best of the authors’ knowledge, this is the first time that the stable hydrogel fibers with a highly biocide behavior have been fabricated using electrospinning.

TEM image of Ag NP-loaded electrospun fiber mat. Reprinted from J. Appl. Polym. Sci., 2012, vol. 126. Rivero PJ, Urrutia A, Goicoechea J, Rodríguez Y, Corres JM, Arregui FJ, Matías IR, An antibacterial submicron fiber mat with in situ synthesized silver nanoparticles, pages 1228–1235. Copyright (2012), with permission from Wiley.
Figure 2

TEM image of Ag NP-loaded electrospun fiber mat. Reprinted from J. Appl. Polym. Sci., 2012, vol. 126. Rivero PJ, Urrutia A, Goicoechea J, Rodríguez Y, Corres JM, Arregui FJ, Matías IR, An antibacterial submicron fiber mat with in situ synthesized silver nanoparticles, pages 1228–1235. Copyright (2012), with permission from Wiley.

In a work of Gawish et al. [190], the polypropylene/Ag composite fibers were produced by the melt-spinning method, and the antibacterial efficacy was evaluated by the percentage count reduction growth of S. aureus and E. coli.

Owing to their high capacity, the nonwoven textiles have been used for a long time as potential filters to remove the harmful air pollutants. In a study by Khosravi and coworkers [191], the needle-punch polypropylene layers were treated with the nanosilver particle through the spray technique. Staphylococcus aureus and E. coli were completely removed from the passing air by the nanosilver-coated layer.

Kiwi and coworkers [192] obtained the uniform nanoparticulate Ag-thin films on the polyester textiles by the direct current (DC)-magnetron sputtering and pulsed DC-magnetron sputtering. The deposition of Ag on the polyester fiber and the bioactivity of the resulting material were observed to be dependent on the type of the sputtering used.

3.3 Copper modified textile fibers

Different synthesis [193, 194] and modification methods for the antimicrobial fabrics involving copper have been proposed in the last years [195]. In the following, several studies are reported and classified on the basis of the natural or synthetic character of the fibers.

3.3.1 Natural fibers

In a recent work, Anita et al. have prepared the copper oxide NPs by a wet chemical method using copper sulfate and sodium hydroxide as the precursors and soluble starch as stabilizing agent [43]. In the first step, the copper oxide NPs were microencapsulated by an ionic gelation method and applied to plain weave cotton fabric by exhaustion, then, in the second step by the pad-dry-cure method. The antibacterial efficacy of the copper oxide-encapsulated coated fabric was determined against S. aureus and E. coli. The authors suggested their employment in the manufacture of medical apparel.

Two works by Kiwi and coworkers [196, 197] addressed unreported features for Cu DC-magnetron sputtering on cotton. They dealt with the preparation and the characterization of CuO, the adhesion of the nanoparticulate CuO on the cotton activated by the RF plasma in comparison with the nonplasma-activated surfaces and the evaluation of E. coli inactivation by cotton/CuO in the dark and under light.

Osorio-Vargas et al. [198] have functionalized the Cu-cotton fabrics by the bipolar asymmetric DC-pulse magnetron sputtering (DCP). The E. coli inactivation was observed within 10 min when Cu was sputtered on the cotton Cu for 60 s. The X-ray photoelectron spectroscopy (XPS) was used to determine the surface atomic concentration of O, Cu, C, and N along the copper speciation during the redox process leading to the E. coli inactivation.

Perelshtein et al. [199] produced the copper oxide NPs synthesized and deposited on the surface of the cotton fabrics by ultrasound irradiation. The process was proposed as a simple and efficient one-step synthesis. The homogeneous distribution of the CuO nanocrystals, 15 nm in size, on the fabric surface was obtained. The antibacterial activity of the CuO-fabric composite was tested, and a significant bactericidal effect, even in a 1% coated fabric (%wt), was found. The application of the coated fabrics was envisaged in wound dressings, bed linings, and as active bandages.

An interesting pilot installation for the scale up of the sonochemically assisted coating of the textile fabrics with the various kinds of NPs was proposed by Abramov et al. [200]. The installation could coat up to 50 m of the continuous cotton fabric per run with CuO or ZnO NPs. The coating was homogeneous, stable, and retained its biocidal properties through at least 20 washing cycles. The CuO-cotton bandages demonstrated good antimicrobial properties against Escherichia coli (see Figure 3).

(A) Picture of the pilot installation described in Ref. [200]. In the inset, the CuO-coated and uncoated spools are shown. (B) HR SEM images of the CuO/cotton bandage prepared on the pilot installation from the 0.02-mol solution of Cu2+: after 10 min of the reaction (a); after 40 min of the reaction (b); after 40 min of the reaction with the addition of 10% of the precursor to the working solution (c); the pristine uncoated cotton bandage (d), the cotton bandage after immersion in the slurry containing copper oxide without sonication (e). Reprinted from Surf. Coat. Technol., 2009, vol. 204, Abramov OV, Gedanken A, Koltypin Y, Perkas N, Perelshtein I, Joyce E, Mason TJ, Pilot scale sonochemical coating of nanoparticles onto textiles to produce biocidal fabrics, pages 718–722, Copyright (2009), with permission from Elsevier.
Figure 3

(A) Picture of the pilot installation described in Ref. [200]. In the inset, the CuO-coated and uncoated spools are shown. (B) HR SEM images of the CuO/cotton bandage prepared on the pilot installation from the 0.02-mol solution of Cu2+: after 10 min of the reaction (a); after 40 min of the reaction (b); after 40 min of the reaction with the addition of 10% of the precursor to the working solution (c); the pristine uncoated cotton bandage (d), the cotton bandage after immersion in the slurry containing copper oxide without sonication (e). Reprinted from Surf. Coat. Technol., 2009, vol. 204, Abramov OV, Gedanken A, Koltypin Y, Perkas N, Perelshtein I, Joyce E, Mason TJ, Pilot scale sonochemical coating of nanoparticles onto textiles to produce biocidal fabrics, pages 718–722, Copyright (2009), with permission from Elsevier.

Chattopadhyay and Patel [201] produced the copper nanocolloids prepared by the chemical reduction of copper salt using sodium borohydride in the presence of trisodium citrate. The results of the particle size analysis showed that the average particle size varied from 60 to 100 nm. The treatments of the nanocopper colloidal solution on the cotton improved its antimicrobial efficiency (soil burial test) and also influenced the tensile strength of the fabric sample positively.

The synthesis of the copper alginate-cotton cellulose (CACC) composite fibers were proposed by Grace et al. [202]. The CACC fibers were prepared by immersing the cotton fibers in aqueous solution of sodium alginate, followed by the ionic crosslinking of the alginate chains within the cotton cellulose fibers with Cu(II) ions. Finally, the CACC fibers were reduced by sodium borohydride to yield the copper NP-loaded composite fibers and investigated for biocidal action toward E. coli. It was found that the CACC fibers possessed both the fair mechanical strength and antibacterial action. The authors suggested these fibers have great potential as dressing materials. Another work of Grace et al. [203] described the release of copper(II) ions from the cellulose fibers, which were chemically modified by periodate-induced oxidation of cellulose, followed by the covalent attachment of the biopolymer chitosan. The fibers showed an antibacterial activity against E. coli. In addition, the borohydride-induced reduction of these fibers also yields the copper NP-loaded fibers, which also possess fair antibacterial properties. In this case, the authors recommended these fibers to be used in burn/wound dressing and also in the fabrication of antibacterial dressing (see Figure 4).

Picture showing plain cotton fibers (A), copper-bound chitosan-attached cellulose fibers (B), nanocopper loaded chitosan cotton fibers (C). Reprinted from J. Appl. Polym. Sci., 2009, vol. 11, Grace M, Bajpai SK, Chand N, Copper (II) ions and copper nanoparticles-loaded chemically modified cotton cellulose fibers with fair antibacterial properties, pages 757–766, Copyright (2009), with permission from Wiley.
Figure 4

Picture showing plain cotton fibers (A), copper-bound chitosan-attached cellulose fibers (B), nanocopper loaded chitosan cotton fibers (C). Reprinted from J. Appl. Polym. Sci., 2009, vol. 11, Grace M, Bajpai SK, Chand N, Copper (II) ions and copper nanoparticles-loaded chemically modified cotton cellulose fibers with fair antibacterial properties, pages 757–766, Copyright (2009), with permission from Wiley.

Berendjchi et al. [204] discussed the synthesis of silica sol, doped with two different amounts (0.5% and 2% wt/wt) of the Cu NPs. The cotton fabric samples were impregnated by the prepared sols and tested successfully against S. aureus and E. coli.

In a work by Gabbay et al. [205], both the natural and synthetic fibers have been considered. The authors reported that the copper-impregnated fibers of the cotton and polyester containing 3–10%wt Cu had shown significant antifungal and antimicrobial properties. The biocidal characteristics were reported to be permanent, unaffected by extreme washing conditions, and they did not interfere with the processing of the final products (e.g., color, press, etc.).

In another work by Kiwi and coworkers [206], Cu DC-magnetron sputtering leads to the thin metallic semitransparent gray-brown Cu coating composed of the Cu nanoparticulate in the nanometer range, as found by the electron microscopy. The DC-magnetron sputtering (DCMS) for 40 s of Cu on cotton inactivated the E. coli within 30 min under visible light and within 120 min in the dark. For a longer DCMS time of 180 s, the Cu content was ca. 0.3% w/w, but the bacterial inactivation kinetics under light was observed within 30 min, as was the case for the 40-s sputtered sample. The Cu ionic species were hypothesized to play a key role in the E. coli inactivation. The bioactive Cu was also deposited on the polyester in the form of Cu2O and CuO, as shown by the XPS and antibacterial tests [206].

3.3.2 Synthetic fibers

The Cu polyester thin-sputtered layers on the textile fabrics showed an acceptable bacterial inactivation kinetics using the sputtering methods [206]. Recently, Rio et al. [207] tested the antimicrobial activity of the Cu-sputtered polyester surfaces, obtained by DC-magnetron sputtering, against methicillin-resistant S. aureus (MRSA). The Cu-polyester microstructure was characterized by the high-resolution transmission electron microscopy to determine the microstructure of the Cu NPs and by profilometry to assess the thickness of the layers. The sputtering at 300 mA for 160 s led to a Cu film thickness of 20 nm (100 Cu layers) containing 0.2% (wt/wt) polyester. The viability of the MRSA strain ATCC 43300 on the Cu-sputtered polyester was evaluated by four methods: mechanical detachment, microcalorimetry, direct transfer onto the plates, and stereomicroscopy. The low efficacy of the mechanical detachment impeded the bacterial viability estimations. The microcalorimetry provided only semiquantitative results. The direct transfer onto the plates and stereomicroscopy seemed to be the most suitable methods to evaluate the bacterial inactivation potential of the Cu-sputtered polyester surfaces, as they presented the least experimental bias. The Cu-polyester samples sputtered for 160 s were further tested against 10 clinical MRSA isolates and showed a high level of bactericidal activity, with a 4-log(10) reduction in the initial MRSA load [10(6) colony-forming units (CFUs)] within 1 h. The Cu-sputtered polyester surfaces might be useful to prevent the transmission of the health care-associated infection pathogens [207].

3.4 Zinc oxide-modified textile fibers

The metal oxides such as TiO2, ZnO, MgO, and CaO are of particular interest because of their stability under harsh process conditions and also generally regarded as safe materials to human beings and animals [199, 208].

In particular, ZnO is generally nontoxic, capable of photocatalytic oxidation, and chemically stable under exposure to high temperature [209]. Furthermore, the ZnO NPs have some advantages, compared to nano-Ag, too, such as lower cost, white color [210], and UV-blocking property [44, 211]. ZnO is also used to reinforce the polymeric bionanocomposites [211] and to enhance the wear-resistant phase and antisliding phase in the composites as a consequence of its high elastic modulus and strength [212].

3.4.1 Natural fibers

There are only a few methods, such as the pad-dry-cure method, radiation, and thermal treatments, that describe the coating of the ZnO NPs on the cotton fabric.

El Shafei and Abou-Okeil [213] focused their paper on the preparation and characterization of ZnO/carboxymethyl chitosan bionanocomposite (see Figure 5). The application of the bionanocomposite to the textile materials aimed at producing functional textiles by the pad-dry-cure method to impart UV and antibacterial activity to the cotton fabric. In another study from the same authors [108], the synthesis of the reactive preformed polymers (PFP) and their application to the cotton fabrics was proposed. The grafting of the PFP to the cotton fabrics in the presence of ZnO NPs and/or epichlorohydrin imparted an antibacterial activity to the substrates, which withstood 20 times of washing while keeping 70% of this activity.

SEM pictures of the pristine cotton fabric (B) and cotton fabric treated (A) with ZnO/CMCTS bionanocomposite. Reprinted from Carbohydr. Polym., 2011, vol. 83, El Shafei A, Abou-Okeil A, ZnO/carboxymethyl chitosan bionano-composite to impart antibacterial and UV protection for cotton fabric. Pages 920–925, Copyright (2011), with permission from Elsevier.
Figure 5

SEM pictures of the pristine cotton fabric (B) and cotton fabric treated (A) with ZnO/CMCTS bionanocomposite. Reprinted from Carbohydr. Polym., 2011, vol. 83, El Shafei A, Abou-Okeil A, ZnO/carboxymethyl chitosan bionano-composite to impart antibacterial and UV protection for cotton fabric. Pages 920–925, Copyright (2011), with permission from Elsevier.

Rajendran et al. [214] investigated the zinc oxide NPs prepared by the wet chemical method and directly applied on to the 100% cotton-woven fabric using the pad-dry-cure method. The antibacterial activity of the finished fabrics was studied, and their results showed that the finished fabric demonstrated a significant antibacterial activity against S. aureus. The wash durability study of the treated fabric was also carried out and found to withstand up to 25 wash cycles.

Selvam et al. [215] carried out the functionalization of the cotton fabric with poly-N-2-pyrrolidone (PVP) for improving the dyeability of the dichlorotriazine dyes, and subsequently, the ZnO NPs were coated by the pad-dry-cure method on the functionalized textiles. The PVP-modified cotton fabrics showed good dye uptake, color strength, and fastness properties for the three dichlorotriazine-reactive dyes. In the antibacterial tests against S. aureus and E. coli, the PVP/ZnO-modified fabrics showed very good bacterial reduction. These fabrics were proposed as wound cloths, surgical cloths, sportswear, and kids wear.

Li and coworker [216] have investigated the durability of the antibacterial activity of the nano-ZnO functionalized cotton fabric to sweat. The durability of the antibacterial activity of the finished fabric in alkaline, acidic, and inorganic salt artificial sweat solution was evaluated. The results showed better salt and alkaline resistances than acid resistances for the treated fabrics. A negative surface charge was deduced for the ZnO NPs, and it was envisaged that the illumination can increase the antibacterial performance.

The chalcones and ZnO flower-like nanorods were prepared and coated by Sivakamur et al. on the cotton cloth with acacia as the binder [217]. The antibacterial activity of the coated cotton was tested against S. aureus, E. Coli, and P. aeruginosa in terms of live bacterial load, as measured by the CFUs, adhered on the cotton surface. More than 99% reduction in bacterial load was observed toward all the three microorganisms.

Three shapes of the nano-ZnO were prepared and then applied on the cotton fabrics by Neamjan and coworkers [218]: ZnO multipetals, ZnO rods, and ZnO spherical particles. The as-prepared suspension was applied onto the cotton fabrics via the pad-dry-cure process at 150°C. All the treated samples showed good antibacterial activity against S. Aureus, but the shape of the ZnO particles showed a little effect on this activity.

Very recently, Subash et al. developed the NP-coated cotton fabric [219]. Zinc oxide NPs were prepared by the wet chemical method using zinc nitrate and sodium hydroxide. The antibacterial property of the treated fabric was analyzed. The results indicated that the 2% zinc oxide NP (200 nm)- coated fabric have a high antibacterial efficiency (99.9% against S. aureus and 80% against E. coli), and upon washing the coated fabric (five hand washes), the antibacterial activity was found to be 98% against S. aureus and 75% against E. coli [219].

Cakir et al. [220] provided a new method to impart the antimicrobial properties to the textile fabrics. The Zinc oxide (ZnO) NPs were synthesized in the reverse micelle cores of PS(10912)-b-PAA(3638) copolymer synthesized by the atom transfer radical polymerization at various precursor:copolymer ratios (10:1, 20:1, and 40:1). The size and morphology of the ZnO NPs were characterized via the TEM and XRD measurements. Then, the copolymer solution including the ZnO NPs was deposited onto the cotton fabrics to enhance the UV-blocking, self-cleaning, and antibacterial properties. In fact, the nano-ZnO-coated textile samples exhibited an antibacterial activity against E. coli and S. aureus (see Figure 6)

Antibacterial activities of the nanoZnO-coated textile samples with 10:1, 20:1, and 40:1 of the Zn+2:copolymer ratio against E. coli (A) and S. aureus (B). Reprinted from Coll. Surf. A: Physicochem. Eng. Aspects., 2012, vol. 414, Cakir BA, Budama L, Topel O, Hoda N, Synthesis of ZnO nanoparticles using PS-b-PAA reverse micelle cores for UV protective, self-cleaning and antibacterial textile applications, pages 132–139, Copyright (2012), with permission from Elsevier.
Figure 6

Antibacterial activities of the nanoZnO-coated textile samples with 10:1, 20:1, and 40:1 of the Zn+2:copolymer ratio against E. coli (A) and S. aureus (B). Reprinted from Coll. Surf. A: Physicochem. Eng. Aspects., 2012, vol. 414, Cakir BA, Budama L, Topel O, Hoda N, Synthesis of ZnO nanoparticles using PS-b-PAA reverse micelle cores for UV protective, self-cleaning and antibacterial textile applications, pages 132–139, Copyright (2012), with permission from Elsevier.

Finally, the immobilization of the ZnO NPs on the cotton fabrics using poly 4-styrenesulfonic acid (PSS) was studied by Iamphaojeen and Siriphannon [221]. The resulting immobilization of the ZnO nanocrystals on the cotton fabrics was investigated by SEM, XRF, and XPS. The ZnO-immobilized cotton fabrics inhibited the growth of S. aureus, as demonstrated by the AATCC 147-2004 standard test method.

3.4.2 Synthetic fibers

Among the publications regarding the ZnO-modified synthetic textiles, the ZnO-loaded polyamide 6 (PA6) nanocomposite fibers [222], ZnO modified polyester nonwoven fabrics [223], and polypropylene/nanometal composite fibers [190] are particularly interesting.

Skrifvars and coworkers [222] investigated the preparation of the PA6/ZnO nanocomposite fibers by the melt-spinning method. The nanocomposite fibers containing the ZnO NPs at four different loadings were prepared. The antibacterial activity of the fibers against S. aureus as a Gram-positive bacterium and Klebsiella pneumoniae as a Gram-negative bacterium was determined according to ASTM E 2149-0. It is found that the dispersion of the ZnO particles within the PA6 matrix is homogenous. The antibacterial activity tests showed that the PA6/ZnO nanocomposite fibers exhibit antibacterial efficiency related to their NP contents. An increase in the amount of the NPs caused an increase in the antibacterial activity of the fibers. These nanocomposite fibers were proposed for medical application, such as sutures and meshes.

Jesionowski et al. [223] synthesized ZnO by precipitation using the emulsion method, and then, the ZnO phases were deposited onto the polyester nonwoven fabrics. The antimicrobial properties of the modified textiles were evaluated against S. aureus and E. coli by the screening method according to PN-EN ISO20645, on the basis of the presence and size of the inhibition zone. The polyester nonwoven fabric modified with zinc oxide revealed a high antibacterial activity.

Finally, in the work of Gawish et al. [190], the PP/Zn composite fibers were produced by the melt-spinning method, and the antibacterial efficacy was evaluated by the percentage count reduction growth of S. aureus and E. coli. A metal content slightly higher than 0.1% was required to obtain a significant antibacterial activity, and the antibacterial efficacy of PP fibers increased by increasing the nanoantimicrobial content.

4 Modification methods for fabric applications

In the previous sections, we have reviewed several methods to modify the natural and synthetic fibers for improving their properties and, in particular, for providing antimicrobial activity. This paragraph is focused on the selected deposition techniques that are presently employed in our laboratories for the controlled modification of the textiles by the nanoantimicrobial inclusions. Three possible approaches are briefly discussed, e.g., the photoreduction of silver salts, ion beam sputtering deposition of metal-fluoropolymer nanocomposites, and electrochemical synthesis of metal nanoantimicrobial colloids.

4.1 Photoreduction of silver salt

An innovative technology to obtain the antibacterial textile by silver particle deposition has been developed and patented by Sannino and coworkers [224]. The technology, based on the photoreduction in situ of a silver salt, can be applied to many different types of substrate [225] and, in particular, it has been extensively studied, and it is being applied to textile, both natural and synthetic (wool, flax, cotton, polyester, nylon, etc.) [161, 226, 227]. The durable antibacterial textile for many applications was obtained, from the common knitwear or underwear treated with silver to guarantee a major welfare, to the hospital textile, where silver represents a promising instrument for advanced wound dressing [228] or antiseptic bandage [229].

The treatment consists of the deposition of a silver solution on the surface of substrate by spray coating or dip coating; then, the impregnated substrates are exposed to an ultraviolet source, like a UV lamp, in order to induce the photoreduction.

Usually, in this process, a silver salt, used as precursor of the metallic silver, is dissolved in methanol or in a mixture of methanol and water. The process, in which methanol is both the solvent and reducing agent, is based on the following chemical reaction:

Agn+2Ag++CH3OH+hυ=>Agn+2+2H++CH2O

The mentioned technology ensures that the silver particles remain firmly bonded to the substrate, and the antibacterial effect is permanent also after the several industrial washing cycles. The hypoallergenicity and the skin irritability of the antibacterial samples of the fabrics were verified by appropriate analysis carried by specialized laboratories.

4.2 Ion beam sputtering deposition of metal-fluoropolymer nanocomposites

Ion beam cosputtering (IBS) is a low-cost deposition technique, which is very versatile for the production of the thin metal-fluoropolymer nanostructured films, by means of a controlled inclusion of the metal NPs in a fluoropolymer (CFx)-dispersing matrix.

The metal-fluoropolymer (Au-CFx, Ag-CFx, Pd-CFx, Cu-CFx) nanocomposites can be deposited at room temperature and at a pressure of 10-4 mbar on the different substrates by cosputtering a Teflon target and a metal one (Au, Ag, Pd, Cu) with Ar+ ion beams.

The good reproducibility of the deposition experimental parameters (ion-beam energy and current) allows the control of the growth rate of each component in the nanocomposite material and, therefore, the metal volume fraction value, which can range from 0 to 1.

The IBS results to be competitive with the other methods for the realization of the innovative textile products because it also allows for the multifunctional modification of textiles, with both antibacterial and dirt-repellent as well as water-repellent properties. A schematic diagram of the dual-beam IBS setup and more details of the deposition technique have been reported elsewhere [230–233].

The textile fibers coated with a sputtered metal-fluoropolymeric nanocomposite film show a challenging antibacterial activity. When left in contact with the culture broths of the target microorganisms, the IBS-treated fiber surface releases the metal ions included, which interact with bacteria (e.g., E. coli, S. aureus, etc.) inhibiting their growth into colonies. The extent of such antimicrobial properties depends on the metal loading in the composite.

A tuneable metal loading and, therefore, a tuneable metal ion release in solution, a very good stability toward storage and, most of all, a marked biostatic effect on the different target microorganisms strongly support the application of the metal-CFx coatings in the important fields such as food chemistry, biomedicine, and antibacterial textile.

4.3 Electrochemical synthesis of silver or copper nanoparticles

The sacrificial anode electrosynthesis of the metal NPs in the presence of the cationic surfactants is a simple and particularly versatile method, which allows to tune the particle size through simple parameters, such as the electrolysis potential [234].

The sacrificial anode electrolytic process was performed by using a tree-electrode cell, equipped with a bioactive metal sheet (copper, zinc, silver, etc.) as the anode electrode, a platinum sheet as the cathode electrode, and the proper reference electrode. During the process, when the applied potential is sufficiently high, the anode dissolves under the form of metal ions that are subsequently reduced at the cathode surface in the presence of proper surfactants, such as tetra-n-alkyl-ammonium salts, which stabilize the NP under the form of a core-shell structure in which the copper (or silver, or zinc oxide) core is surrounded by the quaternary ammonium ions. The surfactant is both used as the base electrolyte and as stabilizing agent, as it adsorbs on the surface of the metal clusters (produced by means of the cathodic reduction), thus, preventing their excessive growth and promoting their dissolution as the spherical NPs with high morphological stability [194, 235–238].

We have electrosynthesized several bioactive nanocolloids, which have been then used as modifiers of commercially available polymers and textiles. The peculiarity of these materials consists of the stabilized structure of the NPs, which allows a gradual and controlled copper ion release, when the nanocoating is exposed to aqueous solutions. The release extent of the bioactive ions is easily tuneable by a proper selection of the preparation parameters, such as the metal loading in the coating [239].

The nanostructured coatings are capable of releasing metal ions in a culture broth of living microorganisms in a concentration range that can be finely selected in order to be effective (e.g., biocide or biostatic) toward several target organisms [194, 235–238].

5 Conclusions and perspectives

A concise overview of technologies in use for the controlled inclusion/deposition of antimicrobial nanophases into textile goods has been provided in this paper. The referenced studies have been classified as a function of the composition of the nanoantimicrobial agent –herein, we have decided to focus on the most diffused ones, namely: copper-, silver-, and zinc oxide-based nanophases-, and as a function of natural/synthetic composition of the textile. Very short descriptions about the processes and nanomaterials developed in the authors laboratories have been provided, as well.

The large number of academic studies cited outlines the importance of this research field in real-life applications and usages. Interestingly, patented processes are attracting even a greater interest towards this field in recent years. The worldwide demand for “smart” products combining several properties, including efficient antibacterial activity, is stimulating the diffusion of real-life goods which do not employ conventional antibiotics. In this respect, using NPs as smart surface modifiers providing a controlled release of bioactive ions [239] can offer several advantages, preventing or limiting direct nanotoxicity and other undesired effects. Bioactivity patterns activated by NPs can be certainly more complex than just those based on ionic activity [240, 241], and concerns about nanotoxicology issues related to the use of the most common nanoantimicrobials have been risen by several authors [242]. Nevertheless, the number of patents on nanoantimicrobials-modified textiles is increasing and covers nowadays almost any combination of different metal(s), and kind of textile fiber [243–248]. Among the most promising directions for a further development of this field, the authors of this review envisage the development of nanoantimicrobials-modified nonwoven fabric [249], medical gauzes [250], wound dressing [247], wet-tissues [251] and other disposable goods for medical or health-care [252] purposes.

Financial support from the Italian Ministry M.I.U.R., Programma Operativo Nazionale Ricerca e Competitività, Project:“SILVER-Tecnologie e Trattamenti nano-antimicrobici per la modifica controllata di prodotti tessili e altri prodotti” (PON01_02210) and Apulian Region, Project: “Laboratorio di tecnologie di modificazione superficiale di fibre naturali per il rilancio del settore tessile in Puglia(cod. 056) is gratefully acknowledged. MKR is thankful to FAPESP, Brazil, for the financial assistance concerning the scientific visit to the University of Campinas.

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About the article

Lorena Carla Giannossa

Lorena Carla Giannossa is a PhD in Chemical Sciences and took her Master’s Degree in Chemistry at the University of Bari “Aldo Moro” in 2005. She is the author of several papers published in international peer-reviewed journals, congress proceedings, and chapters of books. She has participated at numerous national and international conferences and is involved in multidisciplinary projects, working together with researchers of different backgrounds. Her fields of expertise are mainly the development of new methods and the use of the conventional ones modified to be specifically applied to particular samples (e.g., for AAS and IPC-MS analyses), the employment of techniques like MO, SEM-EDS, FT-IR, and Raman Spectroscopy.

Daniela Longano

Daniela Longano is a PhD in the Chemistry of Innovative Materials and received her Master’s Degree in Industrial and Environmental Biotechnologies at the University of Bari “Aldo Moro” in December 2008. During her PhD, her research interests were focused on preparation, analytical characterization, and antimicrobial activity of copper-based nanocomposites. At present, she has a postdoc fellowship at the Chemistry Department of the University of Bari “Aldo Moro” working on the preparation, surface modifications by plasma deposition, and characterization of several materials for tissue engineering.

Nicoletta Ditaranto

Nicoletta Ditaranto is a PhD in the Chemistry of Innovative Materials and presently is an Assistant Professor at the University of Bari. She received the “Ambrogio Mazzucotelli” award in Analytical Spectroscopy in 2006 and the “Young Scientist Award” in 2009 at the e-MRS. Her research interests are focused on the synthesis, spectroscopic characterization, and application of advanced nanostructured materials as antimicrobial coatings, and nanomaterials for catalysts and sensors. She is the coauthor of 39 papers (22 in peer-reviewed journals), two European patents, and more than 90 conference contributions.

Maria Angela Nitti

Maria Angela Nitti is a PhD in the Physics of Innovative Materials and graduated in Physics in July 2001. Presently, she has a Scientific Research Grant at the University of Bari “Aldo Moro”, working on controlled surface functionalization by means of the ion beam cosputtering technique, in order to obtain new multifunctional nanocoatings, combining the antimicrobial properties of metal or metal oxide nanoparticles with the antistain ones of a PTFE matrix. Her research interests deal also with the optical, photoemissive, and morphological characterization of the obtained innovative nanostructured materials for real-life applications. She is the coauthor of more than 20 papers published in international peer-reviewed journals and congress proceedings.

Federica Paladini

Federica Paladini is a PhD student in Materials and Structures Engineering and has been working in the biomaterial research group at the University of Salento (Lecce) for 4 years. Her research interests lie in the development of innovative and advanced products based on nanomaterials for biomedical application and engineering of surfaces. Her main publications deal with the synthesis and deposition of silver nanoparticles for antimicrobial application, with a particular focus on the development and characterization of silver-treated medical devices and textiles.

Mauro Pollini

Mauro Pollini is a PhD in Materials Engineering and has been a member of the research team in the Biomaterials Laboratory at the University of Salento (Lecce) for 10 years. His research interests lie in the engineering of surfaces and advanced materials in nanotechnology. He has published more than 10 works of his research activities and more than 13 patents, among which are the technologies and processes to obtain innovative and advanced products such as silver-treated materials obtained by the in situ synthesis and deposition of silver nanoparticles. Since 2008, he is the founding member of “Silvertech”, a spin-off company that promotes the transfer and scale up of such antibacterial technology.

Mahendra Rai

Mahendra Rai is a Professor and Head at the Department of Biotechnology, Sant Gadge Baba Amravati University at Amravati, Maharashtra, India. He was a Visiting Scientist at the Department of Bioenergetics, University of Geneva, Switzerland, in 2004 and at the Department of Plant Protection of Debrecen University, Debrecen, Hungary, in 2005 and 2008. He visited the Department of Chemical Biology, University of Campinas, Brazil, under the Indo-Brazil Research Programme (DST-CNPq collaboration) in 2009, 2011, and 2012. Recently (May–June, 2012), he was a Visiting Professor in the Nicolaus Copernicus University, Torun, Poland. Presently, he is a Visiting Professor at the University of Campinas, Brazil. His area of expertise includes microbial biotechnology and nanobiotechnology. His present research interests include the application of nanobiotechnology in medicine and agriculture, in particular, the use of metallic nanoparticles as the new generation of antimicrobials. He has published more than 200 research papers in India and abroad. In addition, he has edited/authored more than 25 books.

Alessandro Sannino

Alessandro Sannino is a PhD in Materials Engineering and is an Associate Professor at the University of Salento (Lecce). He is also a member of the Doctoral Committee at the University of Salento, University of Naples “Federico II” and the School of Medicine of the Second University of Naples. Since 2004, he is a Visiting Scientist at the Massachusetts Institute of Technology, MA. His research activity focuses on the natural polymer-based systems for biomedical and tissue engineering applications, with a special focus on collagen and cellulose-based materials. He has published more than 70 works and more than 20 patents. He has also directed 30 research projects and collaboration projects in public-private partnership. In 2011, he became a member of the “Consiglio Superiore di Sanita‘” due to his expertise in the development of therapeutic approaches in tissue engineering. He is also the founding member of three spin-off companies.

Antonio Valentini

Antonio Valentini is an Associate Professor of Applied Physics at the MFN Science Faculty of Bari University. Since 1984, he has been a scientific collaborator of the Istituto Nazionale di Fisica Nucleare (INFN). He has covered various research activities on thin film depositions and characterizations for applications in solid state devices and sensors: metal/semiconductor interfaces for ohmic and for rectifier contacts on semiconductors; materials for UV photocathode applications; new generation of organic vapor sensors based on metal-polymer composites. He also collaborates with the development of polymer and polymer-metal composites for biological and manufacturing applications. He is the author of more than 80 scientific articles on international peer-reviewed journals.

Nicola Cioffi

Nicola Cioffi is a PhD in Chemistry of Innovative Materials and graduated in Chemistry in 1997 and was awarded as the “2001 Best Young Researcher” by the Analytical Chemistry Division, Italian Chemical Society. Presently, he is an Associate Professor at the University of Bari “Aldo Moro”. He is a member of the editorial board of six journals, and has been the editor of special issues of the Sensor Letters, Molecules, and of the Springer book Nano-antimicrobials. He is the author of four European patents, 116 publications (69 peer-reviewed journals), and some 180 conference communications. His research interests deal with nanomaterials for the life sciences, including nanomaterials for sensors, bioanalysis, mass spectrometry/proteomics, green chemistry/catalysis, and antimicrobial nanomaterials.


Corresponding author: Nicola Cioffi, Department of Chemistry, University of Bari “Aldo Moro”, Via Orabona 4, 70126 Bari, Italy


Received: 2013-01-28

Accepted: 2013-03-25

Published Online: 2013-04-24

Published in Print: 2013-06-01


Citation Information: Nanotechnology Reviews, Volume 2, Issue 3, Pages 307–331, ISSN (Online) 2191-9097, ISSN (Print) 2191-9089, DOI: https://doi.org/10.1515/ntrev-2013-0004.

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