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Volume 43, Issue 4


Cylindrospermopsin: cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life

Michał Adamski
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
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/ Ewelina Chrapusta
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
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/ Beata Bober
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
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/ Ariel Kamiński
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
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/ Jan Białczyk
  • Department of Plant Physiology and Development, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland
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Published Online: 2015-01-04 | DOI: https://doi.org/10.2478/s13545-014-0148-5


Cylindrospermopsin (CYN) is a cytotoxin produced by several species of cyanobacteria, which occur all over the world. It was demonstrated that CYN has a wide spectrum of biological activity in animal cells, involving hepatotoxicity, genotoxicity, cytotoxicity and carcinogenic potential, and is considered as one of the factors that caused human poisoning in Palm Island (Australia) and in Caruaru (Brazil). This compound may be introduced into organism by several ways, including consumption of water, fishes and seafood as well as accidental swallowing or aerosol spray inhalation during recreational using of reservoirs covered by cyanobacterial blooms. The information about the CYN impact on environment and its degradation processes under natural conditions is scant. Taking this into consideration CYN should be regarded as a potential threat to human health and life. This review presents physicochemical characteristic and biological activity of CYN, occurrence in freshwaters and its sensitivity to the influence of some environmental factors.

Keywords: cyanobacteria; cylindrospermopsin; biological activity; natural degradation; toxicity

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Published Online: 2015-01-04

Published in Print: 2014-12-01

Citation Information: Oceanological and Hydrobiological Studies, Volume 43, Issue 4, Pages 442–449, ISSN (Online) 1897-3191, ISSN (Print) 1730-413X, DOI: https://doi.org/10.2478/s13545-014-0148-5.

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