Jump to ContentJump to Main Navigation
Show Summary Details

Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

12 Issues per year

IMPACT FACTOR increased in 2015: 2.615
5-year IMPACT FACTOR: 3.127
Rank 60 out of 163 in category Chemistry, Multidisciplinary in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.012
Source Normalized Impact per Paper (SNIP) 2014: 1.187
Impact per Publication (IPP) 2014: 2.785

See all formats and pricing
Volume 72, Issue 3 (Jan 2000)


The chelate effect in binding, catalysis, and chemotherapy

Ronald Breslow
  • Corresponding author
  • Department of Chemistry, Columbia University, New York, New York 10027, USA
/ Sandro Belvedere
  • Corresponding author
  • Department of Chemistry, Columbia University, New York, New York 10027, USA
/ Leland Gershell
  • Corresponding author
  • Department of Chemistry, Columbia University, New York, New York 10027, USA
/ David Leung
  • Corresponding author
  • Department of Chemistry, Columbia University, New York, New York 10027, USA
Published Online: 2009-01-01 | DOI: https://doi.org/10.1351/pac200072030333

Cyclodextrin (CD) dimers bind amino acid side chains, and such binding can dissociate aggregated proteins, including citrate synthase (dimer) and lactic dehydrogenase (tetramer). A CD dimer can bind a hydrophobic photosensitizer that, upon irradiation, generates singlet oxygen. This cleaves the dimer and releases the photosensitizer. CD dimers in a cytochrome P-450 mimic steer catalyzed hydroxylation to a bound steroid with geometric control. Chelate binding has also led to a group of cytodifferentiating agents whose mechanism has been recently established. They have promising anticancer properties, and are currently entering human trials as therapeutic agents.


International IUPAC Symposium on Bioorganic Chemistry (ISBOC-5), International Symposium on Bioorganic Chemistry, ISBOC, Bioorganic Chemistry, 5th, Pune, India, 2000-01-30–2000-02-04

About the article

Published Online: 2009-01-01

Published in Print: 2000-01-01

Citation Information: Pure and Applied Chemistry, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac200072030333. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

R. Coşkun, M. Okutan, O. Yalçın, and A. Kösemen
Acta Physica Polonica A, 2012, Volume 122, Number 4, Page 683
Guzmán Sánchez, David Curiel, Witold Tatkiewcz, Imma Ratera, Alberto Tárraga, Jaume Veciana, and Pedro Molina
Chemical Science, 2014, Volume 5, Number 6, Page 2328
Daniel Granadero, Jorge Bordello, Maria Jesus Pérez-Alvite, Mercedes Novo, and Wajih Al Soufi
International Journal of Molecular Sciences, 2010, Volume 11, Number 1, Page 173
Yuyan Shao, Tianbiao Liu, Guosheng Li, Meng Gu, Zimin Nie, Mark Engelhard, Jie Xiao, Dongping Lv, Chongmin Wang, Ji-Guang Zhang, and Jun Liu
Scientific Reports, 2013, Volume 3
E. Buck and R. Iyengar
Science Signaling, 2003, Volume 2003, Number 209, Page re14
Agnieszka Bartoszewicz, Rocío Marcos, Suman Sahoo, A. Ken Inge, Xiaodong Zou, and Belén Martín-Matute
Chemistry - A European Journal, 2012, Volume 18, Number 45, Page 14510
Siva Prasad Das, Seshadri Reddy Ankireddy, Jeena Jyoti Boruah, and Nashreen S. Islam
RSC Advances, 2012, Volume 2, Number 18, Page 7248
Lun K. Tsou, Rishi K. Jain, and Andrew D. Hamilton
Journal of Porphyrins and Phthalocyanines, 2004, Volume 08, Number 02, Page 141
Peter J. Jervis, Marie Moulis, John-Paul Jukes, Hemza Ghadbane, Liam R. Cox, Vincenzo Cerundolo, and Gurdyal S. Besra
Carbohydrate Research, 2012, Volume 356, Page 152
Helene L. Åmand, Bengt Nordén, and Kristina Fant
Biochemical and Biophysical Research Communications, 2012, Volume 418, Number 3, Page 469
Lindong Gao, Xuhong Qian, Li Zhang, and Yuanxing Zhang
Journal of Photochemistry and Photobiology B: Biology, 2001, Volume 65, Number 1, Page 35
Bernabé L. Rivas, Antonio E. Maureira, and María A. Mondaca
European Polymer Journal, 2008, Volume 44, Number 7, Page 2330
Emilio Alvarez-Parrilla, Pedro Ramos Cabrer, Anand Pal Singh, Wajih Al-Soufi, Francisco Meijide, Eugenio Rodríguez Núñez, and José Vázquez Tato
Supramolecular Chemistry, 2002, Volume 14, Number 5, Page 397
Bernabé L. Rivas, Antonio Maureira, Catherine Guzmán, David Contreras, Wolfgang Kaim, and Kurt E. Geckeler
Polymer Bulletin, 2011, Volume 67, Number 5, Page 763
Rastislav Šípoš, Jozef Šima, Mário Izakovič, and Pavol Tarapčík
Journal of Solution Chemistry, 2011, Volume 40, Number 7, Page 1200
Jeena Jyoti Boruah, Diganta Kalita, Siva Prasad Das, Saurav Paul, and Nashreen S. Islam
Inorganic Chemistry, 2011, Volume 50, Number 17, Page 8046
Pawilai Chinwangso, Andrew C. Jamison, and T. Randall Lee
Accounts of Chemical Research, 2011, Volume 44, Number 7, Page 511
P Thangadurai, S Balaji, and P T Manoharan
Nanotechnology, 2008, Volume 19, Number 43, Page 435708
Stéphane Menuel, Nathalie Azaroual, David Landy, Natacha Six, Frédéric Hapiot, and Eric Monflier
Chemistry - A European Journal, 2011, Volume 17, Number 14, Page 3949
Bernabé L. Rivas, Eduardo D. Pereira, Manuel Palencia, and Julio Sánchez
Progress in Polymer Science, 2011, Volume 36, Number 2, Page 294
Bernabé L. Rivas, Antonio Maureira N., and Catherine Guzmán S.
Macromolecular Symposia, 2010, Volume 287, Number 1, Page 69
Mercedes Alvarez Alcalde, Alvaro Antelo, Aida Jover, Francisco Meijide, and José Vázquez Tato
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, Volume 63, Number 3-4, Page 309
Maricica Munteanu, Soowhan Choi, and Helmut Ritter
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2008, Volume 62, Number 3-4, Page 197
Zakir M. O. Rzayev, B. Kirci Denizli, and Haluk Denizli
Journal of Applied Polymer Science, 2008, Volume 109, Number 2, Page 903
Duc-Truc Pham, Philip Clements, Christopher J. Easton, John Papageorgiou, Bruce L. May, and Stephen F. Lincoln
New Journal of Chemistry, 2008, Volume 32, Number 4, Page 712
Silvio Aime, Eliana Gianolio, Giovanni Palmisano, Bruna Robaldo, Alessandro Barge, Luisa Boffa, and Giancarlo Cravotto
Organic & Biomolecular Chemistry, 2006, Volume 4, Number 6, Page 1124
P. C. Deb, L. D. Rajput, A. K. Agrawal, P. K. Singh, V. Hande, and S. Sasane
Polymers for Advanced Technologies, 2005, Volume 16, Number 9, Page 681
Bernab� L. Rivas, S. Amalia Pooley, Eduardo D. Pereira, Roc�o Cid, Maribel Luna, M. Antonieta Jara, and Kurt E. Geckeler
Journal of Applied Polymer Science, 2005, Volume 96, Number 1, Page 222
Serap Kavlak, Hatice Kaplan Can, and Ali G�ner
Journal of Applied Polymer Science, 2004, Volume 92, Number 4, Page 2698
De-Qi Yuan, Jianzhong Lu, Masato Atsumi, Jia-Ming Yan, Masaaki Kai, and Kahee Fujita
Organic & Biomolecular Chemistry, 2007, Volume 5, Number 18, Page 2932

Comments (0)

Please log in or register to comment.
Log in