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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen


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1365-3075
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Volume 73, Issue 8

Issues

Low-temperature manufacturing of fine pharmaceutical powders with supercritical fluid aerosolization in a Bubble Dryer®

R. E. Sievers
  • Corresponding author
  • Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, CO 80309-0215, USA
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/ E. T. S. Huang
  • Corresponding author
  • Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, CO 80309-0215, USA
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/ J. A. Villa
  • Corresponding author
  • Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, CO 80309-0215, USA
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/ J. K. Kawamoto
  • Corresponding author
  • Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, CO 80309-0215, USA
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/ M. M. Evans
  • Corresponding author
  • Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, CO 80309-0215, USA
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/ P. R. Brauer
Published Online: 2009-01-01 | DOI: https://doi.org/10.1351/pac200173081299

Aerosols play an important role in thin film deposition, fine powder generation, and drug delivery. Green processes to form aerosols are needed to eliminate the use of toxic organic solvents and minimize the production of liquid wastes and the emission of halogenated and oxidant-forming organic compounds. We have developed a new patented process, Carbon Dioxide-Assisted Nebulization with a Bubble Dryer® (CAN-BD), that can generate a dense aerosol with small droplet and microbubble sizes that are dried to form particles less than 3 µm in diameter [1­9]. The process uses carbon dioxide as an aerosolization aid, and this permits drying at lower temperature than usually needed in conventional spray-drying. Intimate mixing of supercritical carbon dioxide with aqueous protein solutions causes the formation of microbubbles, which are rapidly dried in less than 5 s. The process is more environmentally benign than traditionally used methods, and is superior when thermally unstable materials are being processed. Fine-particle pharmaceutical powders can be rapidly and easily made by this new CAN-BD process, requiring less energy and eliminating residues of toxicologically or environmentally objectionable solvents. Manufacturing dry powders of pharmaceuticals for pulmonary drug delivery and increasing bioavailability are the purposes of developing and marketing the new Temco Bubble Dryer.

Conference

IUPAC CHEMRAWN XIV Conference on Green Chemistry:Toward Environmentally Benign Processes and Products, Chemical Research Applied To World Needs, CHEMRAWN, Chemical Research Applied To World Needs, Boulder, Colorado, USA, 2001-06-09–2001-06-13

About the article

Published Online: 2009-01-01

Published in Print: 2001-08-01


Citation Information: Pure and Applied Chemistry, Volume 73, Issue 8, Pages 1299–1303, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac200173081299.

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