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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

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1365-3075
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Volume 74, Issue 7

Issues

Molecular basis of sweet taste in dipeptide taste ligands

M. Goodman
  • Corresponding author
  • Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0343, USA
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/ J. R. Del Valle
  • Corresponding author
  • Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0343, USA
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/ Y. Amino
  • Corresponding author
  • Ajinomoto Co., Inc., AminoScience Laboratories, 1-1 Suzuki-Cho, Kawasaki-Ku, Kawasaki-Shi 210-8681, Japan
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/ E. Benedetti
  • Corresponding author
  • Center of Biocrystallography, University of Naples, Via Mezzocannone 6, Naples, Italy
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Published Online: 2009-01-01 | DOI: https://doi.org/10.1351/pac200274071109

In this presentation, we describe an integrated approach for the molecular basis for sweet taste among dipeptide-based ligands. By comparing the results obtained from X-ray diffraction studies with the conformations from NMR analysis and molecular modeling, we have observed recurring topochemical motifs that agree with previous models for sweet taste. In our examination of the unexplored D zone of the Tinti­Nofre model, we have uncovered a sweet potency enhancing effect of a new set of aralkyl-substitutions on dipeptide ligands, which reveals the importance of aromatic­aromatic interactions in maintaining high potency.

Conference

International Symposium on Sweeteners, International Symposium on Sweeteners, SWEET, Sweeteners, 2nd, Hiroshima, Japan, 2001-11-13–2001-11-17

About the article

Published Online: 2009-01-01

Published in Print: 2002-01-01


Citation Information: Pure and Applied Chemistry, Volume 74, Issue 7, Pages 1109–1116, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac200274071109.

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