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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen

12 Issues per year


IMPACT FACTOR 2017: 5.294

CiteScore 2017: 3.42

SCImago Journal Rank (SJR) 2017: 1.212
Source Normalized Impact per Paper (SNIP) 2017: 1.546

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1365-3075
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Volume 74, Issue 7

Issues

Chemistry of phenolic compounds of licorice (Glycyrrhiza species) and their estrogenic and cytotoxic activities

Taro Nomura
  • Corresponding author
  • School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Toshio Fukai
  • Corresponding author
  • School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Toshiyuki Akiyama
  • Corresponding author
  • Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-Chome, Shinagawa-ku, Tokyo 140-8710, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-01-01 | DOI: https://doi.org/10.1351/pac200274071199

The genus Glycyrrhiza consists of about 30 species in which G. glabra, G. uralensis, G. inflata, G. aspera, G. korshinskyi, and G. eurycarpa are generally recognized as licorice because of their sweet taste. Except G. korshinskyi, we examined isoprenoid-substituted phenols of these licorices. Each plant could be characterized by some isoprenoid phenols. We also investigated the biological activities of the Glycyrrhiza phenols. In the course of screening phytoestrogen in medicinal plants, six Glycyrrhiza phenols exhibited the binding affinities for the bovine uterine estrogen receptor. The affinity of a dihydrostilbene with two 3-methyl-2-butenyl (prenyl) groups, gancaonin R, was higher than those of isoflavone phytoestrogens (genistein and daidzein) in dietary foods. The affinities of the other five phenols, a flavanone (liquiritigenin), two prenylflavanones (isobavachin and sigmoidin B), a prenylated coumestan (glycyrol), and a pyranoisoflav-3-ene (glabrene), were similar to that of the dietary isoflavone, genistein or daidzein. Cytotoxic activities of the Glycyrrhiza phenols against human oral tumor cell lines and HIV-infected MT-4 cells were also reviewed.

Conference

International Symposium on Sweeteners, International Symposium on Sweeteners, SWEET, Sweeteners, 2nd, Hiroshima, Japan, 2001-11-13–2001-11-17

About the article

Published Online: 2009-01-01

Published in Print: 2002-01-01


Citation Information: Pure and Applied Chemistry, Volume 74, Issue 7, Pages 1199–1206, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac200274071199.

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