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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen

12 Issues per year


IMPACT FACTOR 2017: 5.294

CiteScore 2017: 3.42

SCImago Journal Rank (SJR) 2017: 1.212
Source Normalized Impact per Paper (SNIP) 2017: 1.546

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1365-3075
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Volume 74, Issue 7

Issues

Antidiabetogenic constituents from several natural medicines

Hisashi Matsuda
  • Corresponding author
  • Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Toshio Morikawa
  • Corresponding author
  • Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Masayuki Yoshikawa
  • Corresponding author
  • Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2009-01-01 | DOI: https://doi.org/10.1351/pac200274071301

In the course of our studies on antidiabetogenic and antidiabetic principles of natural medicines and medicinal foodstuffs, we have isolated salacinol and kotalanol with unique thiosugar sulfonium sulfate inner salt structures from the antidiabetic Ayurvedic traditional medicines, Salacia reticulata and S. oblonga. Salacinol and kotalanol showed potent inhibitory activities against intestinal α-glucosidase, and also inhibitory effects of salacinol on the increase in serum glucose levels in maltose- and sucrose-loaded rats were found to be more potent than those of acarbose. In addition, various flavonoids with potent inhibitory activities against rat lens aldose reductase such as quercitrin desmanthin-1 and guaijaverin were isolated from Myrcia multiflora and several natural medicines, and some structural requirements of flavonoids for aldose reductase inhibitory activity were clarified.

Conference

International Symposium on Sweeteners, International Symposium on Sweeteners, SWEET, Sweeteners, 2nd, Hiroshima, Japan, 2001-11-13–2001-11-17

About the article

Published Online: 2009-01-01

Published in Print: 2002-01-01


Citation Information: Pure and Applied Chemistry, Volume 74, Issue 7, Pages 1301–1308, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac200274071301.

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