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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

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Volume 76, Issue 10 (Jan 2004)

Issues

Past, present and futute of cyclodextrin research

J. Szejtli
Published Online: 2009-01-01 | DOI: https://doi.org/10.1351/pac200476101825

The macrocyclic cyclodextrins (enzymic conversion products of starch) were discovered in 1891, and the structures were elucidated in the mid-1930s. Their industrial significance become obvious in the 1970s, and by now thousand of tons of the three cyclodextrins (alpha-, beta-, and gamma-CD) and of their chemical derivatives and inclusion complexes are produced industrially. The outer surface of these doughnut-shaped molecules is hydrophilic, but they possess an axial open cavity, which is of hydrophobic character and capable of including other apolar molecules (or their moiety) in case of geometric compatibility. This is the essence of molecular encapsulation by inclusion complex formation.

Conference

International Conference on Solution Chemistry, International Conference on Solution Chemistry, ICSC, Solution Chemistry, 28th, Debrecen, Hungary, 2003-08-23–2003-08-28

About the article

Published Online: 2009-01-01

Published in Print: 2004-01-01


Citation Information: Pure and Applied Chemistry, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/pac200476101825.

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