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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

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Essential fatty acid components and antioxidant activities of eight Cephalaria species from southwestern Anatolia

Süheyla Kırmızıgül1 / Nazlı Böke1 / Hüseyin Sümbül2 / R. Süleyman Göktürk2 / Nazlı Arda3

1Faculty of Science, Department of Chemistry, Ege University, 35100, Bornova, İzmir, Turkey

2Faculty of Science and Arts, Department of Biology, Akdeniz University, 07058, Antalya, Turkey

3Faculty of Science, Department of Molecular Biology and Genetics, İstanbul University, 34118, Vezneciler, İstanbul, Turkey

Citation Information: Pure and Applied Chemistry. Volume 79, Issue 12, Pages 2297–2304, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200779122297, January 2009

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The hexane extracts of eight Cephalaria (Dipsacaceae) species, which were collected from southwestern Anatolia, were obtained by Soxhlet apparatus. The fatty acids were derived to methyl esters and determined by gas chromatography/flame ionization detector (GC/FID) and gas chromatography/mass spectrometry (GC/MS) systems. The dominant fatty acid components and maximum percentages were detected as myristic [in C. joppica (17.48 %)], palmitic [in C. cilicica, C. elmaliensis, C. isaurica, C. scoparia (19.51 %), and C. gazipashaensis], linoleic [in C. joppica (33.02 %), C. elmaliensis, C. dipsacoides, and C. gazipashaensis], α-linolenic (ALA) [in C. cilicica, C. elmaliensis, C. isaurica, C. scoparia, C. lycica, and C. gazipashaensis (47.95 %)] and oleic [in C. isaurica and C. dipsacoides (40.66 %)] acids. The antioxidant activity of all hexane extracts was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric thiocyanate (FTC), and thiobarbituric acid (TBA) methods. The results indicate that hexane extracts of Cephalaria species possess considerable antioxidant activity. The highest radical scavenging activity was detected in C. isaurica (IC50 = 741 μg/mL). The most effective species on lipid peroxidation are C. lycica and C. gazipashaensis in FTC and TBA assays, respectively. This study reveals that Cephalaria species are attractive sources of fatty acid components, especially the essential ones, as well as of effective natural antioxidants.

Keywords: antioxidant activity; Cephalaria species; Dipsacaceae; fatty acids; lipid peroxidation; radical scavenging

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