Pure and Applied Chemistry
The Scientific Journal of IUPAC
Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen
IMPACT FACTOR increased in 2015: 2.615
5-year IMPACT FACTOR: 3.127
Rank 60 out of 163 in category Chemistry, Multidisciplinary in the 2015 Thomson Reuters Journal Citation Report/Science Edition
SCImago Journal Rank (SJR) 2014: 1.012
Source Normalized Impact per Paper (SNIP) 2014: 1.187
Impact per Publication (IPP) 2014: 2.785
Antifungal action of chlorogenic acid against pathogenic fungi, mediated by membrane disruption
1School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Daegu 702-701, Korea
International Biotechnology Symposium (IBS 2008): "Biotechnology for the Sustainability of Human Society", 13th, Dalian, China, 2008-10-12–2008-10-17
Citation Information: Pure and Applied Chemistry. Volume 82, Issue 1, Pages 219–226, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/PAC-CON-09-01-08, January 2010
- Published Online:
Chlorogenic acid is a polyphenol compound, derived from several fruit and plants. The aim of this study was to assess the in vitro antifungal activity of chlorogenic acid and its mode of action. The results indicate that chlorogenic acid exhibits antifungal activities against certain pathogenic fungi in an energy-independent manner, without any hemolytic effect on human erythrocytes. To elucidate the antifungal mode of action of chlorogenic acid, flow cytometry analysis by using DiBAC4(3) and changes in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH) were performed with Candida albicans. The results suggest that chlorogenic acid may exert antifungal activity by disrupting the structure of the cell membrane. It is demonstrated that chlorogenic acid is a valid lead compound for the development of bioactive alternatives for treatment of fungal infections.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.