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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

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1365-3075
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Volume 84, Issue 7

Issues

Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds

David O'Hagan
  • Corresponding author
  • EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
  • Other articles by this author:
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/ Yi Wang
  • Corresponding author
  • EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
  • Other articles by this author:
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/ Maciej Skibinski
  • Corresponding author
  • EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
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/ Alexandra M. Z. Slawin
  • Corresponding author
  • EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-04-07 | DOI: https://doi.org/10.1351/PAC-CON-11-09-26

The CF2 group has found applications as a substituent in all classes of organic chemical products from medicinal products to materials, although it is less frequently encountered than the C–F and CF3 substituents. In this review, the geometric influence of placing two fluorine atoms on carbon is considered and in particular, deviations from tetrahedral geometry are noted. The incorporation of the CF2 group into CF2 phosphonates as phosphate mimics is reviewed and the geometric and steric influences of the CF2 group are considered when the substituent is placed within aliphatic chains and aliphatic ring (cyclododecane) systems.

Keywords: conformation; fluorochemistry; organic chemistry; organic materials; structure

Conference

International Conference on Heterocyclic Chemistry (ICHC-23), International Congress on Heterocyclic Chemistry, ICHC, Heterocyclic Chemistry, 23rd, Glasgow, UK, 2011-07-31–2011-08-04

References

About the article

Published Online: 2012-04-07

Published in Print: 2012-04-07


Citation Information: Pure and Applied Chemistry, Volume 84, Issue 7, Pages 1587–1595, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/PAC-CON-11-09-26.

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© 2013 Walter de Gruyter GmbH, Berlin/Boston. Copyright Clearance Center

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