Jump to ContentJump to Main Navigation
Show Summary Details

Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

12 Issues per year

IMPACT FACTOR increased in 2015: 2.615
5-year IMPACT FACTOR: 3.127
Rank 60 out of 163 in category Chemistry, Multidisciplinary in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.012
Source Normalized Impact per Paper (SNIP) 2014: 1.187
Impact per Publication (IPP) 2014: 2.785

See all formats and pricing
Volume 85, Issue 5 (Apr 2013)


Nanowire nanoelectronics: Building interfaces with tissue and cells at the natural scale of biology

Tzahi Cohen-Karni
  • Corresponding author
  • Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
/ Charles M. Lieber
  • Corresponding author
  • Department of Chemistry and Chemical Biology, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Published Online: 2013-04-11 | DOI: https://doi.org/10.1351/PAC-CON-12-10-19

The interface between nanoscale electronic devices and biological systems enables interactions at length scales natural to biology, and thus should maximize communication between these two diverse yet complementary systems. Moreover, nanostructures and nanostructured substrates show enhanced coupling to artificial membranes, cells, and tissue. Such nano–bio interfaces offer better sensitivity and spatial resolution as compared to conventional planar structures. In this work, we will report the electrical properties of silicon nanowires (SiNWs) interfaced with embryonic chicken hearts and cultured cardiomyocytes. We developed a scheme that allowed us to manipulate the nanoelectronic to tissue/cell interfaces while monitoring their electrical activity. In addition, by utilizing the bottom-up approach, we extended our work to the subcellular regime, and interfaced cells with the smallest reported device ever and thus exceeded the spatial and temporal resolution limits of other electrical recording techniques. The exceptional synthetic control and flexible assembly of nanowires (NWs) provides powerful tools for fundamental studies and applications in life science, and opens up the potential of merging active transistors with cells such that the distinction between nonliving and living systems is blurred.

Keywords: biotechnology; nano–bio interfaces; nanowires; synthesis


  • 1

    R. D. Purves. Microelectrode Methods for Intracellular Recording and Ionophoresis, Biological Techniques series, Academic Press, London (1981).

  • 2

    [Crossref], B. Sakmann, E. Neher. Annu. Rev. Physiol. 46, 455 (1984).

  • 3

    [Crossref], I. R. Efimov, V. P. Nikolski, G. Salama. Circ. Res. 95, 21 (2004).

  • 4

    [Crossref], M. Scanziani, M. Hausser. Nature 461, 930 (2009).

  • 5

    [Crossref], M. Halbach, U. Egert, J. Hescheler, K. Banach. Cell. Physiol. Biochem. 13, 27 (2003).

  • 6

    [Crossref], M. Reppel, F. Pillekamp, Z. J. Lu, M. Halbach, K. Brockmeier, B. K. Fleischmann, J. Hescheler. J. Electrocardiol. 37, 104 (2004).

  • 7

    [Crossref], S. Ingebrandt, C. K. Yeung, M. Krause, A. Offenhausser. Biosens. Bioelectron. 16, 565 (2001).

  • 8

    [Crossref], C. K. Yeung, S. Ingebrandt, M. Krause, A. Offenhausser, W. Knoll. J. Pharmacol. Toxicol. Methods 45, 207 (2001).

  • 9

    [Crossref], D. J. Banks, W. Balachandran, P. R. Richards, D. Ewins. Physiol. Meas. 23, 437 (2002).

  • 10

    [Crossref], O. J. Prohaska, F. Olcaytug, P. Pfundner, H. Dragaun. IEEE Trans. Biomed. Eng. 33, 223 (1986).

  • 11

    [Crossref], A. M. Morales, C. M. Lieber. Science 279, 208 (1998).

  • 12

    [Crossref], J. T. Hu, T. W. Odom, C. M. Lieber. Acc. Chem. Res. 32, 435 (1999).

  • 13

    [Crossref], W. Lu, C. M. Lieber. J. Phys. D: Appl. Phys. 39, R387 (2006).

  • 14

    [Crossref], Y. Cui, C. M. Lieber. Science 291, 851 (2001).

  • 15

    [Crossref], H. Yan, H. S. Choe, S. W. Nam, Y. Hu, S. Das, J. F. Klemic, J. C. Ellenbogen, C. M. Lieber. Nature 470, (2011).

  • 16

    [Crossref], W. Lu, C. M. Lieber. Nat. Mater. 6, 841 (2007).

  • 17

    [Crossref], D. Wang, F. Qian, C. Yang, Z. H. Zhong, C. M. Lieber. Nano Lett. 4, 871 (2004).

  • 18

    [Crossref], Y. Cui, Q. Wei, H. Park, C. M. Lieber. Science 293, 1289 (2001).

  • 19

    [Crossref], F. Patolsky, G. Zheng, O. Hayden, M. Lakadamyali, X. Zhuang, C. M. Lieber. Proc. Natl. Acad. Sci. USA 101, 14017 (2004).

  • 20

    [Crossref], G. F. Zheng, F. Patolsky, Y. Cui, W. U. Wang, C. M. Lieber. Nat. Biotechnol. 23, 1294 (2005).

  • 21

    [Crossref], N. S. Ramgir, Y. Yang, M. Zacharias. Small 6, 1705 (2010).

  • 22

    S. M. Sze, K. K. Ng. Physics of Semiconductor Devices, 3rd ed., Wiley-Interscience, Hoboken, NJ (2007).

  • 23

    [Crossref], M. J. Schoning, A. Poghossian. Analyst 127, 1137 (2002).

  • 24

    [Crossref], E. Stern, J. F. Klemic, D. A. Routenberg, P. N. Wyrembak, D. B. Turner-Evans, A. D. Hamilton, D. A. LaVan, T. M. Fahmy, M. A. Reed. Nature 445, 519 (2007).

  • 25

    [Crossref], P. Xie, Q. Xiong, Y. Fang, Q. Qing, C. M. Lieber. Nat. Nanotechnol. 7, 119 (2012).

  • 26

    [Crossref], M. Arnold, E. A. Cavalcanti-Adam, R. Glass, J. Blummel, W. Eck, M. Kantlehner, H. Kessler, J. P. Spatz. ChemPhysChem 5, 383 (2004).

  • 27

    [Crossref], M. Arnold, M. Schwieder, J. Blummel, E. A. Cavalcanti-Adam, M. Lopez-Garcia, H. Kessler, B. Geiger, J. P. Spatz. Soft Matter 5, 72 (2009).

  • 28

    [Crossref], J. Park, S. Bauer, A. Pittrof, M. S. Killian, P. Schmuki, K. von der Mark. Small 8, 98 (2012).

  • 29

    [Crossref], J. Park, S. Bauer, K. von der Mark, P. Schmuki. Nano Lett. 7, 1686 (2007).

  • 30

    [Crossref], T. Cohen-Karni, K. J. Jeong, J. H. Tsui, G. Reznor, M. Mustata, M. Wanunu, A. Graham, C. Marks, D. C. Bell, R. Langer, D. S. Kohane. Nano Lett. 12, 5403 (2012).

  • 31

    [Crossref], N. J. Sniadecki, R. A. Desai, S. A. Ruiz, C. S. Chen. Ann. Biomed. Eng. 34, 59 (2006).

  • 32

    [Crossref], C. Prinz, W. Hallstrom, T. Martensson, L. Samuelson, L. Montelius, M. Kanje. Nanotechnology 19, 345101 (2008).

  • 33

    [Crossref], G. Cellot, E. Cilia, S. Cipollone, V. Rancic, A. Sucapane, S. Giordani, L. Gambazzi, H. Markram, M. Grandolfo, D. Scaini, F. Gelain, L. Casalis, M. Prato, M. Giugliano, L. Ballerini. Nat. Nanotechnol. 4, 126 (2009).

  • 34

    [Crossref], N. A. Kotov, J. O. Winter, I. P. Clements, E. Jan, B. P. Timko, S. Campidelli, S. Pathak, A. Mazzatenta, C. M. Lieber, M. Prato, R. V. Bellamkonda, G. A. Silva, N. W. S. Kam, F. Patolsky, L. Ballerini. Adv. Mater. 21, 3970 (2009).

  • 35

    [Crossref], B. Taccardi, B. B. Punske, E. Macchi, R. S. Macleod, P. R. Ershler. Am. J. Physiol. Heart. Circ. Physiol. 294, H1753 (2008).

  • 36

    M. L. Cohen, R. H. Hoyt, J. E. Saffitz, P. B. Corr. Am. J. Physiol. 257, H681 (1989).

  • 37

    [Crossref], B. P. Timko, T. Cohen-Karni, G. Yu, Q. Qing, B. Tian, C. M. Lieber. Nano Lett. 9, 914 (2009).

  • 38

    [Crossref], A. Javey, S. Nam, R. S. Friedman, H. Yan, C. M. Lieber. Nano Lett. 7, 773 (2007).

  • 39

    [Crossref], M. C. McAlpine, R. S. Friedman, S. Jin, K. H. Lin, W. U. Wang, C. M. Lieber. Nano Lett. 3, 1531 (2003).

  • 40

    [Crossref], T. Takenobu, T. Takahashi, T. Kanbara, K. Tsukagoshi, Y. Aoyagi, Y. Iwasa. Appl. Phys. Lett. 88, 033511 (2006).

  • 41

    [Crossref], F. Patolsky, B. P. Timko, G. Yu, Y. Fang, A. B. Greytak, G. Zheng, C. M. Lieber. Science 313, 1100 (2006).

  • 42

    [Crossref], T. S. Pui, A. Agarwal, F. Ye, N. Balasubramanian, P. Chen. Small 5, 208 (2009).

  • 43

    [Crossref], T. Cohen-Karni, B. P. Timko, L. E. Weiss, C. M. Lieber. Proc. Natl. Acad. Sci. USA 106, 7309 (2009).

  • 44

    [Crossref], A. Cohen, J. Shappir, S. Yitzchaik, M. E. Spira. Biosens. Bioelectron. 23, 811 (2008).

  • 45

    [Crossref], S. Kodambaka, J. Tersoff, M. C. Reuter, F. M. Ross. Science 316, 729 (2007).

  • 46

    [Crossref], C. Y. Wen, M. C. Reuter, J. Bruley, J. Tersoff, S. Kodambaka, E. A. Stach, F. M. Ross. Science 326, 1247 (2009).

  • 47

    [Crossref], V. Schmidt, J. V. Wittemann, U. Gösele. Chem. Rev. 110, 361 (2010).

  • 48

    [Crossref], C. W. Yang, Z. Zhong, C. M. Lieber. Science 310, 1304 (2005).

  • 49

    [Crossref], T. E. Clark, P. Nimmatoori, K.-K. Lew, L. Pan, J. M. Redwing, E. C. Dickey. Nano Lett. 8, 1246 (2008).

  • 50

    [Crossref], T. Cohen-Karni, D. Casanova, J. F. Cahoon, Q. Qing, D. Bell, C. M. Lieber. Nano Lett. 12, 2639 (2012).

  • 51

    [Crossref], T. Cohen-Karni, Q. Qing, Q. Li, Y. Fang, C. M. Lieber. Nano Lett. 10, 1098 (2010).

  • 52

    B. Hille. Ion Channels of Excitable Membranes, 3rd ed., Sinauer (2001).

  • 53

    [Crossref], J. M. Dubach, S. Das, A. Rozenzweig, H. A. Clark. Proc. Natl. Acad. Sci. USA 106, 16145 (2009).

  • 54

    [Crossref], Q. Qing, S. K. Pal, B. Tian, X. Duan, B. P. Timko, T. Cohen-Karni, V. N. Murthy, C. M. Lieber, Proc. Natl. Acad. Sci. USA 107, 1882 (2010).

  • 55

    [Crossref], B. Tian, T. Cohen-Karni, Q. Qing, X. Duan, P. Xie, C. M. Lieber. Science 329, 831 (2010).

  • 56

    [Crossref], R. Gao, S. Strehle, B. Tian, T. Cohen-Karni, P. Xie, X. Duan, Q. Qing, C. M. Lieber. Nano Lett. 12, 3329 (2012).

  • 57

    [Crossref], X. Duan, R. Gao, P. Xie, T. Cohen-Karni, Q. Qing, H. S. Choe, B. Tian, X. Jiang, C. M. Lieber. Nat. Nanotechnol. 7, 174 (2012).

  • 58

    [Crossref], T. C. Pappas, W. M. Wickramanyake, E. Jan, M. Motamedi, M. Brodwick, N. A. Kotov. Nano Lett. 7, 513 (2007).

  • 59

    [Crossref], X. Jiang, B. Tian, J. Xiang, F. Qian, G. Zheng, H. Wang, L. Mai, C. M. Lieber. Proc. Natl. Acad. Sci. USA 108, 12212 (2011).

  • 60

    [Crossref], J. T. Robinson, M. Jorgolli, A. K. Shalek, M.-H. Yoon, R. S. Gertner, H. Park. Nat. Nanotechnol. 7, 180 (2012).

  • 61

    [Crossref], B. D. Almquist, N. A. Melosh. Proc. Natl. Acad. Sci. USA 107, 5815 (2010).

  • 62

    [Crossref], T. Cohen-Karni, R. Langer, D. S. Kohane. ACS Nano 6, 6541 (2012).

  • 63

    [Crossref], B. Tian, J. Liu, T. Dvir, L. Jin, J. H. Tsui, Q. Qing, Z. Suo, R. Langer, D. S. Kohane, C. M. Lieber. Nat. Mater. 11, 986 (2012).

About the article

Published Online: 2013-04-11

Published in Print: 2013-04-11

Citation Information: Pure and Applied Chemistry, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/PAC-CON-12-10-19. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Junli Wang, Hui Feng, Weiling Fan, Kangmin Chen, and Qing Yang
Advances in Materials Physics and Chemistry, 2013, Volume 03, Number 06, Page 289
Canan Dagdeviren, Yewang Su, Pauline Joe, Raissa Yona, Yuhao Liu, Yun-Soung Kim, YongAn Huang, Anoop R. Damadoran, Jing Xia, Lane W. Martin, Yonggang Huang, and John A. Rogers
Nature Communications, 2014, Volume 5
Roey Elnathan, Moria Kwiat, Fernando Patolsky, and Nicolas H. Voelcker
Nano Today, 2014, Volume 9, Number 2, Page 172
Yuming Sun, Yuehua Su, Zhenhong Dai, and Weitian Wang
Journal of Optics, 2014, Volume 16, Number 5, Page 055003
Stefan Giselbrecht, Bastian E. Rapp, and Christof M. Niemeyer
Angewandte Chemie, 2013, Volume 125, Number 52, Page 14190

Comments (0)

Please log in or register to comment.
Log in