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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen

IMPACT FACTOR 2017: 5.294

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Volume 85, Issue 7


From elementary reactions to chemical relevance in the photodynamic therapy of cancer

Luis G. Arnaut / Sebastião J. Formosinho
Published Online: 2013-02-25 | DOI: https://doi.org/10.1351/PAC-CON-12-08-16

Theories of radiationless conversions and of chemical processes were employed to design better photosensitizers for photodynamic therapy (PDT). In addition to photostability and intense absorption in the near infrared, these photosensitizers were required to generate high yields of long-lived triplet states that could efficiently transfer their energy, or an electron, to molecular oxygen. The guidance provided by the theories was combined with the ability to synthesize large quantities of pure photosensitizers and with the biological screening of graded hydrophilicities/lipophilicities. The theoretical prediction that halogenated sulfonamide tetraphenylbacteriochlorins could satisfy all the criteria for ideal PDT photosensitizers was verified experimentally.

Keywords: kinetics; oxygen; photochemistry; porphyrins


IUPAC Symposium on Photochemistry, International Symposium on Photochemistry, PHOTO, Photochemistry, XXIVth, Coimbra, Portugal, 2012-07-15–2012-07-20


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About the article

Published Online: 2013-02-25

Published in Print: 2013-02-25

Citation Information: Pure and Applied Chemistry, Volume 85, Issue 7, Pages 1389–1403, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1351/PAC-CON-12-08-16.

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