The evolution that has taken place in medicinal chemistry practice as a result of major advances in genomics and molecular biology arising from the Human Genome Project has carried with it an extensive additional working vocabulary that has become both integrated and essential terminology for the medicinal chemist. Some of this augmented terminology has been adopted from the many related and interlocked scientific disciplines with which the modern medicinal chemist must be conversant, but many other terms have been introduced to define new concepts and ideas as they have arisen. In this supplementary Glossary, we have attempted to collate and define many of the additional terms that are now considered to be essential components of the medicinal chemist’s expanded repertoire.
Project Year: 2008, Project Code: 2008-010-1-700
References
1 10.1351/pac199870051129, C. G. Wermuth, C. R. Ganellin, P. Lindberg, L. A. Mitscher. Pure Appl. Chem.70, 1129 (1998).Search in Google Scholar
2 10.1351/goldbook, IUPAC. Compendium of Chemical Terminology, 2nd ed. (the “Gold Book”). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: (2006–) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins.Search in Google Scholar
3 J. Fischer, C. R. Ganellin (Eds.). Analogue-based Drug Discovery, Wiley-VCH, Weinheim (2006).10.1002/3527608001Search in Google Scholar
4 M. Dean, Y. Hamon, G. Chimini. J. Lipid Res.42, 1007 (2001).Search in Google Scholar
5 10.1002/anie.200462661, G. Bringmann, A. J. P. Mortimer, P. A. Keller, M. J. Gresser, J. Garner, M. Breuning. Angew. Chem., Int. Ed.44, 5384 (2005).Search in Google Scholar
6 10.1016/S0065-7743(08)00023-7, M. W. Sinz. Ann. Rep. Med. Chem.43, 405 (2008).Search in Google Scholar
7 R. Ng. Drugs from Discovery to Approval, Wiley-Blackwell (2009).Search in Google Scholar
8 10.1023/A:1015040217741, J. Kelder, P. D. J. Grootenhuis, D. M. Bayada, L. P. C. Delbressine, J. P. Ploemen. Pharm. Res.16, 1514 (1999).Search in Google Scholar
9 10.1021/jm060642i, S. A. Hitchcock, L. D. Pennington. J. Med. Chem.49, 7559 (2006).Search in Google Scholar
10 10.1351/pac200779091583, M. Nordberg, J. H. Duffus, D. M. Templeton. Pure Appl. Chem.79, 1583 (2007).Search in Google Scholar
11 10.1038/nchembio1005-236, T. P. Begley. Nat. Chem. Biol.1, 236 (2005).Search in Google Scholar
12 Pubchem; http://pubchem.ncbi.nlm.nih.gov/.Search in Google Scholar
13 10.1016/S0065-7743(08)61100-8, F. K. Brown. Ann. Rep. Med. Chem.33, 375 (1998).Search in Google Scholar
14 H. Kubinyi. Chemogenomics in Drug Discovery, www.kubinyi.de/schering58-2006.pdf.10.1016/B0-08-045044-X/00113-9Search in Google Scholar
15 10.1016/S0065-7743(04)39012-3, K. G. Carson, B. D. Jaffee, G. C. B. Harriman. Ann. Rep. Med. Chem.39, 149 (2004).Search in Google Scholar
16 G. M. Downs, P. Willett, W. Fisanick. J. Chem. Inf. Comput. Sci.34, 1094 (1994).Search in Google Scholar
17 R. D. Brown, Y. C. Martin. J. Chem. Inf. Comput. Sci.36, 572 (1996).Search in Google Scholar
18 10.1016/S1359-6446(99)01334-3, D. Gorse, A. Rees, M. Kaczorek, R. Lahana. Drug Discovery Today4, 257 (1999).Search in Google Scholar
19 10.2174/138161208784007653, W. M. Lau, A. W. White, S. J. Gallagher, M. Donaldson, G. McNaughton, C. M. Heard. Curr. Pharm. Des.14, 794 (2008).Search in Google Scholar PubMed
20 F. W. Schueller. Chemobiodynamics and Drug Design, p. 405, McGraw-Hill, The Blakiston Division (1960).Search in Google Scholar
21 10.1016/j.drudis.2006.02.006, C. G. Wermuth. Drug Discovery Today11, 348 (2006).Search in Google Scholar PubMed
22 10.1038/nrd2275, J. Owens. Nat. Rev. Drug Discovery6, 187 (2007).Search in Google Scholar
23 10.1038/nbt1273, A. C. Cheng, R. G. Coleman, K. T. Smyth, Q. Cao, P. Soulard, D. R. Caffrey, A. C. Salzberg, E. S. Huang. Nat. Biotech.25, 71 (2007).Search in Google Scholar PubMed
24 10.1016/B978-0-12-386009-5.00004-7, T. L. Doan, M. Pollastri, M. A. Walters, G. I. Georg. Ann. Rep. Med. Chem.46, 385 (2011).Search in Google Scholar
25 10.1351/PAC-REC-09-05-03, J. Proudfoot, O. Nosjean, J. Blanchard, J. Wang, D. Besson, D. Crankshaw, G. Gauglitz, R. Hertzberg, C. Homon, L. Llewellyn, R. Neubig, L. Walker, P. Villa. Pure Appl. Chem.83, 1129 (2011).Search in Google Scholar
26 10.1351/pac200779071153, J. H. Duffus, M. Nordberg, D. M. Templeton Pure Appl. Chem.79, 1153 (2007).Search in Google Scholar
27 10.2174/138920008786485155, K. J. Box, J. E. Comer. Curr. Drug Metab.9, 869 (2008).Search in Google Scholar
28 10.1002/cbdv.200900164, K. J. Box, J. E. Comer, T. Gravestock, M. Stuart. Chem. Biodivers.6, 1767 (2009).Search in Google Scholar
29 10.1351/pac200880020233, H. Gamsjäger, J. W. Lorimer, P. Scharlin, D. G. Shaw. Pure Appl. Chem.80, 233 (2008).Search in Google Scholar
30 S. D. Pickett, C. Luttmann, V. Guerin, A. Laoui, E. James. J. Chem. Inf. Comput. Sci.38, 144 (1998).Search in Google Scholar
31 M. J. McGregor, S. M. Muskal. J. Chem. Inf. Comput. Sci.39, 569 (1999).Search in Google Scholar
32 10.1016/j.drudis.2009.02.008, H. Zhao, Z. Guo. Drug Discovery Today14, 516 (2009).Search in Google Scholar
33 10.1038/nrd3296, J. A. Di Massi, L. A. Faden. Nat. Rev. Drug Discovery10, 23 (2011).Search in Google Scholar
34 10.1016/S0065-7743(07)42028-0, M. Congreve, C. W. Murray, R. Carr, D. C. Rees. Ann. Rep. Med. Chem.42, 431 (2007).Search in Google Scholar
35 10.1021/jm901137j, J. B. Baell, G. A. Holloway. J. Med. Chem.53, 2719 (2010).Search in Google Scholar
36 Medicines and Healthcare Products Regulatory Agency. Good Laboratory Practice: Background and Structure, http://www.mhra.gov.uk/Howweregulate/Medicines/Inspectionandstandards/ GoodLaboratoryPractice/Structure/index.htm.Search in Google Scholar
37 Medicines and Healthcare Products Regulatory Agency. Good Manufacturing Practice, http://www.mhra.gov.uk / Howweregulate /Medicines/Inspectionandstandards/GoodManufacturingPractice/index.htm.Search in Google Scholar
38 IUPAC Green Chemistry Directory. http://www.incaweb.org/transit/iupacgcdir/overview.htm.Search in Google Scholar
39 R. F. Rekker. Hydrophobic Fragmental Constant (Pharmacochemistry library), Elsevier Scientific (1977).Search in Google Scholar
40 The IUPAC International Chemical Identifier (InChI); http://IUPAC.org/inchi/.Search in Google Scholar
41 Solubility definitions; http://sirius-analytical.com; Application note 08/12.Search in Google Scholar
42 10.1016/S1359-6446(04)03069-7, A. L. Hopkins, C. R. Groom, A. Alex. Drug Discovery Today9, 430 (2004).Search in Google Scholar
43 10.1038/nrd2445, P. D. Leeson, B. Springthorpe. Nat. Rev. Drug Discovery6, 881 (2007).Search in Google Scholar PubMed
44 B. G. Katzung. In Basic and Clinical Pharmacology, 9th ed., Lang Medical Books, McGraw-Hill (2004).Search in Google Scholar
45 10.1016/B978-0-12-386009-5.00006-0, K. A. Loomis, G. J. Brock. Ann. Rep. Med. Chem.46, 351 (2011).Search in Google Scholar
46 H. van de Waterbeemd, B. Testa. Adv. Drug Res.16, 85 (1987).Search in Google Scholar
47 10.1351/pac199769051137, H. van de Waterbeemd, R. E. Carter, G. Grassy, H. Kubiny, Y. C. Martin, M. S. Tute, P. Willett. Pure Appl. Chem.69, 1137 (1997).Search in Google Scholar
48 Chronic Lymphocytic Leukemia Research Consortium Glossary. http://cll.ucsd.edu/glossary/ glossary_m.html.Search in Google Scholar
49 10.1021/cn100008c, T. T. Wager, Xinjun Hou, P. R. Verhoest, A. Villalobos. ACS Chem. Neurosci.1, 435 (2010).Search in Google Scholar
50 10.1021/jm9602928, G. W. Bemis, M. A. Murcko. J. Med. Chem.39, 2887 (1996).Search in Google Scholar
51 Australian Academy of Science. Good Prospects Ahead for Data Mining, http://www.science.org.au/nova/050/050glo.htm.Search in Google Scholar
52 U.S. Food and Drug Administration home page. http://www.fda.gov.Search in Google Scholar
53 NIH Center for Macromolecular Modeling and Bioinformatics. Nuclear Hormone Receptors, http://www.ks.uiuc.edu/Research/pro_DNA/ster_horm_rec/.Search in Google Scholar
54 10.1351/pac199971122349, D. Maclean, J. J. Baldwin, V. T. Ivanov, Y. Kato, A. Shaw, P. Schneider, E. M. Gordon. Pure Appl. Chem.71, 2349 (1999).Search in Google Scholar
55 S. C. Smith. In Analogue-based Drug Discovery II, J. Fischer, C. R. Ganellin (Eds.), p. 83, Wiley-VCH, Weinheim (2010).10.1002/9783527630035.ch4Search in Google Scholar
56 10.1016/S0065-7743(07)42029-2, W. J. Egan. Ann. Rep. Med. Chem.42, 449 (2007).Search in Google Scholar
57 National Center for Biotechnology Information. Just the Facts: A Basic Introduction to the Science Underlying NCBI Resources. http://www.ncbi.nlm.nih.gov/About/primer/pharm.html.Search in Google Scholar
58 10.1038/scibx.2012.380, J. Kotz. SciBX5 (15) (2012);Search in Google Scholar
59 10.1023/A:1015040217741, J. Kelder, P. D. J. Grootenhuis, D. M. Bayada, L. P. C. Delbressine, J.-P. Ploemen. Pharmaceutical Res.16, 1514 (1999).Search in Google Scholar
60 D. J. W. Grant. “Theory and origin of polymorphism”, in Polymorphism in Pharmaceutical Solids, H. G. Brittain (Ed.), pp. 1–34, Marcel Dekker, New York (1999).Search in Google Scholar
61 10.1021/jm00120a002, B. E. Evans, K. E. Rittle, M. G. Bock, R. M. DiPardo, R. M. Freidinger, W. L. Whitter, G. F. Lundell, D. F. Veber, P. S. Anderson, R. S. Chang. J. Med. Chem.31, 2235 (1988).Search in Google Scholar
62 Worldwide Protein Databank. http://www.wwpdb.org.Search in Google Scholar
63 10.1016/S0065-7743(04)39024-X, B. Fermini, A. F. Fossa. Ann. Rep. Med. Chem.39, 323 (2004).Search in Google Scholar
64 10.1016/S0169-409X(96)00423-1, C. Lipinski, F. Lombardo, B. W. Dominy, P. J. Feeney. Adv. Drug. Deliv. Res.23, 3 (1997).Search in Google Scholar
65 D. C. Rees, M. Congreve, C. W. Murray, R. Carr. Nat. Rev.3, 660 (2004).Search in Google Scholar
66 10.1016/j.ddtec.2004.10.009, H.-J. Böhm, A. Flohr, M. Stahl. Drug Discovery Today: Technologies1, 217 (2004).Search in Google Scholar
67 10.1016/S0065-7743(03)38027-3, B.-M. Shamoon, C. Reinhard. Ann. Rep. Med. Chem.38, 261 (2003).Search in Google Scholar
68 Daylight Chemical Information Systems home page. http://www.daylight.com.Search in Google Scholar
69 10.1016/S0065-7743(07)42025-5, B. Gomes, D. de Graaf. Ann. Rep. Med. Chem.42, 393 (2007).Search in Google Scholar
70 G. L. Patrick, Organic Chemistry Instant Notes Series. Chemistry Series, 2nd ed., Taylor & Francis Routledge, London (2004).10.4324/9780203427613Search in Google Scholar
71 R. P. Sheridan, S. K. Kearsley. J. Chem. Inf. Comput. Sci.35, 310 (1995).Search in Google Scholar
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