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Pure and Applied Chemistry

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Volume 86, Issue 7


Efficient asymmetric syntheses of alkaloids and medicinally relevant molecules based on heterocyclic chiral building blocks

Ai-E Wang
  • Department of Chemistry and Fujian Provincial Key Laboratory for Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China
  • Other articles by this author:
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/ Pei-Qiang Huang
  • Corresponding author
  • Department of Chemistry and Fujian Provincial Key Laboratory for Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China
  • Email
  • Other articles by this author:
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Published Online: 2014-04-04 | DOI: https://doi.org/10.1515/pac-2013-1210


In this report, we present recent progress in synthetic methodologies based on three heterocyclic chiral building blocks developed from our laboratories. The potential of these chiral building block-based methods in the concise asymmetric synthesis of alkaloids and medicinally interesting molecules has been demonstrated by the total syntheses of 8-aza-prostaglandin E1, 11-hydroxylated analogues of the lead compounds CP-734432 and PF-04475270, (+)-castanospermine, (+)-1-epi-castanospermine, 7-deoxy-6-epi-castanospermine as well as 9-epi-sessilifoliamide J.

Keywords: alkaloids; asymmetric synthesis; chiral building blocks; ICHC-24; synthetic methodology; total synthesis

Article note: A collection of invited papers based on presentations at the 24th International Congress on Heterocyclic Chemistry (ICHC-24), Shanghai, China, 8–13 September 2013.

Dedicated to Prof. Dr. Li-Xin Dai on occasion of his 90th birthday.


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About the article

Corresponding author: Pei-Qiang Huang, Department of Chemistry and Fujian Provincial Key Laboratory for Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China, e-mail:

Published Online: 2014-04-04

Published in Print: 2014-07-22

Citation Information: Pure and Applied Chemistry, Volume 86, Issue 7, Pages 1227–1235, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2013-1210.

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