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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen


IMPACT FACTOR 2017: 5.294

CiteScore 2017: 3.42

SCImago Journal Rank (SJR) 2017: 1.212
Source Normalized Impact per Paper (SNIP) 2017: 1.546

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1365-3075
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Volume 90, Issue 10

Issues

Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on isotopically labelled chemicals and stereoisomers in relation to the Chemical Weapons Convention

Christopher M. Timperley
  • Corresponding author
  • Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK
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/ Jonathan E. Forman
  • Corresponding author
  • Secretary to the Scientific Advisory Board and Science Policy Adviser, Organisation for the Prohibition of Chemical Weapons (OPCW), The Hague, The Netherlands
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/ Mohammad Abdollahi
  • Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran
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/ Abdullah Saeed Al-Amri / Isel Pascual Alonso / Augustin Baulig / Veronica Borrett
  • BAI Scientific, Melbourne, Australia
  • Honorary Fellow, University of Melbourne, Melbourne, Australia
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/ Flerida A. Cariño / Christophe Curty / David Gonzalez / Zrinka Kovarik / Roberto Martínez-Álvarez / Robert Mikulak / Nicia Maria Fusaro Mourão / Ponnadurai Ramasami
  • Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit 80837, Mauritius
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/ Slawomir Neffe / Syed K. Raza / Valentin Rubaylo
  • State Scientific Research Institute of Organic Chemistry and Technology (GosNIIOKhT), Moscow, Russian Federation
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/ Koji Takeuchi / Cheng Tang
  • Office for the Disposal of Japanese Abandoned Chemical Weapons, Ministry of National Defence, Beijing, China
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/ Ferruccio Trifirò / Francois Mauritz van Straten / Paula S. Vanninen
  • VERIFIN, Department of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland
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/ Volodymyr Zaitsev
  • Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
  • Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil
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/ Farhat Waqar / Mongia Saïd Zina / Stian Holen / Hope A. Weinstein
Published Online: 2018-09-19 | DOI: https://doi.org/10.1515/pac-2018-0803

Abstract

The Chemical Weapons Convention (CWC) is an international disarmament treaty that prohibits the development, stockpiling and use of chemical weapons. This treaty has 193 States Parties (nations for which the treaty is binding) and entered into force in 1997. The CWC contains schedules of chemicals that have been associated with chemical warfare programmes. These scheduled chemicals must be declared by the States that possess them and are subject to verification by the Organisation for the Prohibition of Chemical Weapons (OPCW, the implementing body of the CWC). Isotopically labelled and stereoisomeric variants of the scheduled chemicals have presented ambiguities for interpretation of the requirements of treaty implementation, and advice was sought from the OPCW’s Scientific Advisory Board (SAB) in 2016. The SAB recommended that isotopically labelled compounds or stereoisomers related to the parent compound specified in a schedule should be interpreted as belonging to the same schedule. This advice should benefit scientists and diplomats from the CWC’s State Parties to help ensure a consistent approach to their declarations of scheduled chemicals (which in turn supports both the correctness and completeness of declarations under the CWC). Herein, isotopically labelled and stereoisomeric variants of CWC-scheduled chemicals are reviewed, and the impact of the SAB advice in influencing a change to national licensing in one of the State Parties is discussed. This outcome, an update to national licensing governing compliance to an international treaty, serves as an example of the effectiveness of science diplomacy within an international disarmament treaty.

Keywords: Annex on Chemicals; BZ; chemical warfare agent; Chemical Weapons Convention 2017; diastereomer; enantiomer; isotope; isotopically labelled; National Authority; nitrogen mustard; Organisation for the Prohibition of Chemical Weapons (OPCW); organophosphorus nerve agent; sarin; scheduled chemical; science diplomacy; science policy; stereoisomer; sulfur mustard; vesicant

Article note

A special issue containing invited papers on Innovative Technologies for Chemical Security, based on work done within the framework of the Chemical Weapons Convention.

References

About the article

Published Online: 2018-09-19

Published in Print: 2018-10-25


Citation Information: Pure and Applied Chemistry, Volume 90, Issue 10, Pages 1647–1670, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2018-0803.

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©2018 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/.Get Permission

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[2]
Christopher M. Timperley, Jonathan E. Forman, Pal Åas, Mohammad Abdollahi, Djafer Benachour, Abdullah Saeed Al-Amri, Augustin Baulig, Renate Becker-Arnold, Veronica Borrett, Flerida A. Cariño, Christophe Curty, David Gonzalez, Michael Geist, William Kane, Zrinka Kovarik, Roberto Martínez-Álvarez, Robert Mikulak, Nicia Maria Fusaro Mourão, Slawomir Neffe, Evandro De Souza Nogueira, Ponnadurai Ramasami, Syed K. Raza, Valentin Rubaylo, Ahmed E. M. Saeed, Koji Takeuchi, Cheng Tang, Ferruccio Trifirò, Francois Mauritz van Straten, Alejandra G. Suárez, Farhat Waqar, Paula S. Vanninen, Mohammad Zafar-Uz-Zaman, Slavica Vučinić, Volodymyr Zaitsev, Mongia Saïd Zina, Stian Holen, and Fauzia Nurul Izzati
RSC Advances, 2018, Volume 8, Number 73, Page 41731

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