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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen


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Volume 91, Issue 10

Issues

Titanium based complexes with melanin precursors as a tool for directing melanogenic pathways

Giuseppe Vitiello
  • Department of Chemical, Materials and Production Engineering, University of Naples “Federico II”, p.le V. Tecchio 80, 80125 Naples, Italy
  • CSGI, Consorzio interuniversitario per lo sviluppo dei Sistemi a Grande Interfase, Sesto Fiorentino, via della Lastruccia 3, Firenze, Italy
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/ Pietro Melone
  • Department of Chemical, Materials and Production Engineering, University of Naples “Federico II”, p.le V. Tecchio 80, 80125 Naples, Italy
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/ Brigida Silvestri
  • Department of Chemical, Materials and Production Engineering, University of Naples “Federico II”, p.le V. Tecchio 80, 80125 Naples, Italy
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/ Alessandro Pezzella
  • National Interuniversity Consortium of Materials Science and Technology (INSTM), Florence, Italy
  • Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Via Campi Flegrei 34, I-80078 Pozzuoli (NA), Italy
  • Department of Chemical Sciences, University of Naples “Federico II” Via Cintia 4, I-80126 Naples, Italy
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/ Paola Di Donato
  • Institute for Polymers, Composites and Biomaterials (IPCB), CNR, Via Campi Flegrei 34, I-80078 Pozzuoli (NA), Italy
  • Department of Science and Technology, University of Naples “Parthenope”, Centro Direzionale, Isola C4, 80143 Naples, Italy
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/ Gerardino D’Errico
  • Department of Chemical Sciences, University of Naples “Federico II” Via Cintia 4, I-80126 Naples, Italy
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/ Michela Di Napoli
  • Department of Biology, University of Naples “Federico II” Via Cintia 4, I-80126 Naples, Italy
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/ Anna Zanfardino
  • Department of Biology, University of Naples “Federico II” Via Cintia 4, I-80126 Naples, Italy
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/ Mario Varcamonti
  • Department of Biology, University of Naples “Federico II” Via Cintia 4, I-80126 Naples, Italy
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/ Giuseppina Luciani
  • Corresponding author
  • Department of Chemical, Materials and Production Engineering, University of Naples “Federico II”, p.le V. Tecchio 80, 80125 Naples, Italy, Tel.: +390817682433, Fax: +390817682595
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Published Online: 2019-08-17 | DOI: https://doi.org/10.1515/pac-2018-1210

Abstract

Bioinspired melanin based hybrid materials hold huge promise for developing multifunctional systems for a considerable set of applications. Yet, control of melanogenic pathway is a big challenge to allow rational design of nanostructured systems with tuned structures and improved properties. This study proves the ability of titanium ions interactions with melanin precursors in directing melanogenic pathway. To this purpose complementary spectroscopic evidences were collected to reveal that in the presence of a TiO2-sol, amino-acid complex of Ti(IV) ions and DOPA actually inhibits its cyclization, during oxidative process, thus leading to DOPA-based polyphenols, stable even in oxidative environment, rather than eumelanin. This hugely impacts on the biological properties of the final hybrid systems which, discloses relevant and durable antioxidant behavior but poor antimicrobial activity differently from DHICA-based hybrid nanostructures. Overall this study, discloses the high potential of ceramic templated approach in combination with the selection of melanin precursor in achieving a fine tuning of physico-chemical as well as bioactivity of melanin-TiO2 nanostructures, opening new scenarios towards the design of cutting-edge biomaterials with tailored biological properties.

This article offers supplementary material which is provided at the end of the article.

Keywords: antioxidant properties; DOPA; Eurasia 2018; melanin based hybrid materials; Ti(IV)-DOPA complexes

Article note

A collection of invited papers based on presentations at the 15th Eurasia Conference on Chemical Sciences (EuAsC2S-15) held at Sapienza University of Rome, Italy, 5–8 September 2018.

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About the article

Published Online: 2019-08-17

Published in Print: 2019-10-25


Funding Source: University of Naples Federico II Research

Award identifier / Grant number: Finanziamento per la Ricerca di Ateneo, BioDressMel, DR/2017/408−07/02/2017

This work was supported by University of Naples Federico II Research Grant (Finanziamento per la Ricerca di Ateneo, BioDressMel, DR/2017/408−07/02/2017).


Notes: The authors declare no competing financial interest.


Citation Information: Pure and Applied Chemistry, Volume 91, Issue 10, Pages 1605–1616, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2018-1210.

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