Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen


IMPACT FACTOR 2018: 2.350
5-year IMPACT FACTOR: 4.037

CiteScore 2018: 4.66

SCImago Journal Rank (SJR) 2018: 1.240
Source Normalized Impact per Paper (SNIP) 2018: 1.826

Online
ISSN
1365-3075
See all formats and pricing
More options …
Volume 91, Issue 10

Issues

Dual inhibitors of urease and carbonic anhydrase-II from Iris species

Muhammad Saleem
  • Corresponding author
  • Department of Chemistry, University of Education Lahore, Dera Ghazi Khan Campus 32200, Punjab, Pakistan
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sumaira Hareem
  • H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ajmal Khan
  • Natural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Suad Naheed
  • Department of Biotechnology, Jinnah University for Women, 5-C, Nazimabad, Karachi 74600, Pakistan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Muslim Raza
  • Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Riaz Hussain
  • Department of Chemistry, University of Education Lahore, Dera Ghazi Khan Campus 32200, Punjab, Pakistan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Muhammad Imran / M. Iqbal Choudhary
  • Corresponding author
  • H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
  • Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-07-18 | DOI: https://doi.org/10.1515/pac-2019-0407

Abstract

Twenty seven (1–27) known natural organic compounds were isolated for first time from two species of Iris, i.e. loczyi and Iris unguicularis. The structures of these compounds were deduced from the spectral data of NMR, IR, and mass spectrogram. These were evaluated against urease and carbonic anhydrase inhibition studies. For carbonic anhydrase-II inhibition studies, these compounds were evaluated by biochemical mechanism based in vitro bio-assay. Some compounds showed significant inhibition against CA-II enzyme. Compartively, compound (12) showed IC50 value of 17.60 ± 0.08 μM against urease enzyme, while compound (3) was found to be most active against carbonic anhydrase-II, having an IC50 value of 66.27 ± 0.89 μM. Izalpinin (3), 5,7-dihydroxy-2′,6-dimethoxyisoflavone (9), 4′,5,7-trihydroxy-6-methoxyflavanone (16), 4′,5,7-trihydroxy-3′,8-dimethoxyflavanone (20), 8-methoxyeriodictyol (21), and mangiferin (26) were found to be dual inhibitors of both the enyzmes. The most active compounds were docked using Autodock Vina and i-GEMDOCK softwares. The docking and in-vitro results are in agreement which showed secondary interactions with the enzymes. The compounds can serve as therapeutic agents to treat urease and carbonic anhydrase associated disorders.

Keywords: benzene derivatives; carbonic anhydrase inhibition; Eurasia 2018; flavonoids; flavonoid glycosides; Iris loczyi Kan; Iris unguicularis Poir; steroids; terpenoids; urease inhibition; xanthones glycosides

Article note

A collection of invited papers based on presentations at the 15th Eurasia Conference on Chemical Sciences (EuAsC2S-15) held at Sapienza University of Rome, Italy, 5–8 September 2018.

References

  • [1]

    A. U. Rahman, S. Nasim, I. Baig. S. Jalil, I. Orhan, B. Sener, M. I. Choudhary. J. Ethanopharmacol. 86, 177 (2003).CrossrefGoogle Scholar

  • [2]

    M. S. Krishnan. The Wealth of India: A Dictionary of Raw Material and Industrial Products, B. N. Sastri (Ed.), vol. 2, p. 254. Council of Scientific and Industrial Research, New Delhi (2001).Google Scholar

  • [3]

    H. L. T. Mobley, R. P. Hausinger. Microbiol. Rev. 53, 85 (1989).Google Scholar

  • [4]

    C. M. D. Collins, S. E. F. Orazio. Mol. Microbiol. 9, 907 (1993).CrossrefGoogle Scholar

  • [5]

    A. F. Kolodziej. “The chemistry of nickel-containing enzymes”, in Progress in Inorganic Chemistry, K. D. Karlin (Ed.), vol. 41, pp. 493, Wiley, New York (1994).Google Scholar

  • [6]

    H. L. T. Mobley, M. D. Island, R. P. Hausinger. Microbiol. Rev. 59, 451 (1995).Google Scholar

  • [7]

    Y. Qin, J. M. S. Cabral. Appl. Biochem. Biotech, 49, 217 (1994).CrossrefGoogle Scholar

  • [8]

    K. M. Khan, S. Iqbal, M. A. Lodhi, G. M. Maharvi, Z. Ullah, M. I. Choudhary, A. U. Rahman, S. Perveen. Bioorg. Med. Chem. 12, 1963 (2004).CrossrefGoogle Scholar

  • [9]

    C. T. Supuran, A. Scozzafava, A. Casini. Med. Res. Rev. 23, 146 (2003).CrossrefGoogle Scholar

  • [10]

    B. Lankat-Buttgereit, C. Gregel, A. Knolle, A. Hasilik, R. Arnold, R. Goke. Mol. Cell Endocrinol. 214, 149 (2004).CrossrefGoogle Scholar

  • [11]

    V. Achal, X. Pan. Curr. Microbiol. 62, 894 (2011).CrossrefGoogle Scholar

  • [12]

    M. Senturk, I. Gulcin, S. Beydemir, I. Kufrevioglu, C. T. Supuran. Chem. Biol. Drug Des. 77, 494 (2011).CrossrefGoogle Scholar

  • [13]

    P. P. Rao, S. Sulekha, D. V. N. Maithili, P. Nallari. Int. J. Hum. Genet. 6, 153 (2006).CrossrefGoogle Scholar

  • [14]

    P. K. Rangachari. Adv. Physiol. Educ. 31, 140 (2007).CrossrefGoogle Scholar

  • [15]

    Y. T. Ho, A. Purohit, N. Vicker, S. A. P. Newman, J. J. Robinson, M. P. Leese, D. Ganesshapillai, L. W. L. Woo, M. Reed. J. Biochem. Biophys. Res. Commun. 305, 909 (2003).CrossrefGoogle Scholar

  • [16]

    S. Inoshiri, M. Saiki, H. Kohda, H. Otsuka, K. Yamasaki. Phytochemistry 27, 2869 (1988).CrossrefGoogle Scholar

  • [17]

    A. S. Shawl, T. Kumar. Phytochemistry 31, 1399 (1992).CrossrefGoogle Scholar

  • [18]

    T. Jaipetch, V. Reutrakul, P. Tuntiwachwuttikul, T. Santisuk. Phytochemistry 22, 625 (1983).CrossrefGoogle Scholar

  • [19]

    H. M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T. Bhat, H. Weissig, I. N. Shindyalov, P. E. Bourne. Nucl. Acids Res. 28, 235 (2000).CrossrefGoogle Scholar

  • [20]

    W. Kaplan, T. G. Littlejohn. Brief Bioinform 2, 195 (2001).CrossrefGoogle Scholar

  • [21]

    Z. Li, H. Wan, Y. Shi, P. Ouyang. J. Chem. Inform. Comp. Sci. 44, 1886 (2004).CrossrefGoogle Scholar

  • [22]

    M. D. Hanwell, D. E. Curtis, D. C. Lonie, T. Vandermeersch, E. Zurek, G. R. Hutchison. J. Cheminform. 4, 17 (2012).CrossrefGoogle Scholar

  • [23]

    O. Trott, A. J. Olson. J. Comp. Chem. 31, 455 (2010).Google Scholar

  • [24]

    Y. Li, C. M. Frenz, Z. Li, M. Chen, Y. Wang, F. Li, C. Luo, J. Sun, Z. Li, H. Yang. Chem. Biol. Drug Des. 81, 537 (2013).CrossrefGoogle Scholar

  • [25]

    D. Seeliger, B. L. de Groot. J. Comput. Aided Mol. Des. 24, 417 (2010).CrossrefGoogle Scholar

  • [26]

    K. Yellamma, S. Nagaraju, K. Peera, K. Praveen. Int. J. Pharm. Sci. Rev. Res. 22, 296 (2013).Google Scholar

  • [27]

    M. Umamaheswari, A. Madeswaran, K. Asokkumar, T. Sivashanmugam, V. Subhadradevi, P. Jagannath. Der. Pharma. Chem. 3, 240 (2011).Google Scholar

  • [28]

    F. Neville, W. Porshaye, S. Joseph. Open. J. Biophys. 7, 41 (2017).CrossrefGoogle Scholar

About the article

Corresponding authors: Dr. Muhammad Saleem, Department of Chemistry, University of Education Lahore, Dera Ghazi Khan Campus 32200, Punjab, Pakistan, Tel.: +92-064-9260384, Cell#: +92-331-3133952; and Prof. Dr. M. Iqbal Choudhary, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan, Tel.: +92 21 99261701-2, 34824930,34,36, 4824901-02, Fax: +92 21 34819018-9, 99261713-4; and Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia


Published Online: 2019-07-18

Published in Print: 2019-10-25


Funding Source: Higher Education Commission, Pakistan

Award identifier / Grant number: 21-1394

We gratefully acknowledge the Higher Education Commission, Pakistan, for providing financial support under, Funder Id: http://dx.doi.org/10.13039/501100004681, SRGP project No 21-1394 SRGP-HEC entitled, “Bioassay Studies on the Secondary Metabolites of Plants Species for the development of inhibitors of Carbonic Anhydrase-II enzyme”.


Citation Information: Pure and Applied Chemistry, Volume 91, Issue 10, Pages 1695–1707, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2019-0407.

Export Citation

©2019 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/.Get Permission

Comments (0)

Please log in or register to comment.
Log in