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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen


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Volume 91, Issue 2

Issues

Anticancer properties of gold complexes with biologically relevant ligands

Vanesa Fernández-Moreira
  • Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna, No. 12, E-50009 Zaragoza, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Raquel P. Herrera
  • Departamento de Química Orgánica, Laboratorio de Organocatálisis Asimétrica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna, No. 12, E-50009 Zaragoza, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ M. Concepción Gimeno
  • Corresponding author
  • Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna, No. 12, E-50009 Zaragoza, Spain
  • Email
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Published Online: 2018-11-30 | DOI: https://doi.org/10.1515/pac-2018-0901

Abstract

The present review highlights our findings in the field of antitumor gold complexes bearing biologically relevant molecules, such as DNA-bases, amino acids or peptide derivatives. The results show that very active complexes are achieved with this sort of ligands in several cancer cells. In these compounds the gold center is bonded to these biological molecules mainly through a sulfur atom belonging to a cysteine moiety or to a thionicotinic moiety as result of the functionalization of the biological compounds, and additionally phosphines or N-heterocyclic carbenes are present as ancillary ligands. These robust compounds are stable in the biological media and can be transported to their targets without previous deactivation. The presence of these scaffolds represents a good approach to obtain complexes with improved biologically activity, better transport and biodistribution to cancer cells. Thioredoxin reductase (TrxR) has been shown as the main target for these complexes and in some cases, DNA interactions has been also observed.

Keywords: amino acids; antitumor compounds; Distinguished Women in Chemistry and Chemical Engineering; DNA-base derivatives; gold complexes; peptides

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About the article

Published Online: 2018-11-30

Published in Print: 2019-02-25


Citation Information: Pure and Applied Chemistry, Volume 91, Issue 2, Pages 247–269, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2018-0901.

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