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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen

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Volume 91, Issue 4


Half- and mixed-sandwich metallacarboranes for potential applications in medicine

Marta GozziORCID iD: https://orcid.org/0000-0001-5170-9085 / Benedikt SchwarzeORCID iD: https://orcid.org/0000-0002-5815-8703 / Evamarie Hey-HawkinsORCID iD: https://orcid.org/0000-0003-4267-0603
Published Online: 2019-01-25 | DOI: https://doi.org/10.1515/pac-2018-0806


Today, medicinal chemistry is still clearly dominated by organic chemistry, and commercially available boron-based drugs are rare. In contrast to hydrocarbons, boranes prefer the formation of polyhedral clusters via delocalized 3c2e bonds, such as polyhedral dicarba-closo-dodecaborane(12) (closo-C2B10H12). These clusters have remarkable biological stability, and the three isomers, 1,2- (ortho), 1,7- (meta), and 1,12-dicarba-closo-dodecaborane(12) (para), have attracted much interest due to their unique structural features. Furthermore, anionic nido clusters ([7,8-C2B9H11]2−), derived from the neutral icosahedral closo cluster 1,2-dicarba-closo-dodecaborane(12) by deboronation followed by deprotonation are suitable ligands for transition metals and offer the possibility to form metallacarboranes, for example via coordination through the upper pentagonal face of the cluster. The isolobal analogy between the cyclopentadienyl(–1) ligand (Cp) and [C2B9H11]2− clusters (dicarbollide anion, Cb2−) is the motivation in using Cb2− as ligand for coordination to a metal center to design compounds for various applications. This review focuses on potential applications of half- and mixed-sandwich-type transition metal complexes in medicine.

Keywords: biomedical applications; carboranes; Distinguished Women in Chemistry and Chemical Engineering; medicinal chemistry; metallacarboranes


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About the article

Contributed equally.

Published Online: 2019-01-25

Published in Print: 2019-04-24

Funding Source: Verband der Chemischen Industrie

Award identifier / Grant number: 197021

Funding Source: Sächsisches Staatsministerium für Wissenschaft und Kunst

Award identifier / Grant number: LAU-R-N-11-2-0615

Verband der Chemischen Industrie, Funder Id: 10.13039/100007215, Grant Number: 197021 doctoral grant B.S., Sächsisches Staatsministerium für Wissenschaft und Kunst, Funder Id: 10.13039/501100006114, Grant Number: LAU-R-N-11-2-0615 doctoral grant M.G.

Citation Information: Pure and Applied Chemistry, Volume 91, Issue 4, Pages 563–573, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2018-0806.

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