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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Stohner, Jürgen


IMPACT FACTOR 2018: 2.350
5-year IMPACT FACTOR: 4.037

CiteScore 2018: 4.66

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Volume 91, Issue 8

Issues

Current and promising novel drug candidates against visceral leishmaniasis

Rosa M. Reguera / Yolanda Pérez-Pertejo / Camino Gutiérrez-Corbo / Bárbara Domínguez-Asenjo / César Ordóñez / Carlos García-Estrada / María Martínez-Valladares
  • Instituto de Ganadería de Montaña (CSIC), Departamento de Sanidad Animal, Universidad de León, Campus de Vegazana, Grulleros 24346, León, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rafael Balaña-Fouce
Published Online: 2019-06-11 | DOI: https://doi.org/10.1515/pac-2018-1102

Abstract

Leishmaniasis is a group of zoonotic diseases caused by a trypanosomatid parasite mostly in impoverished populations of low-income countries. In their different forms, leishmaniasis is prevalent in more than 98 countries all over the world and approximately 360-million people are at risk. Since no vaccine is currently available to prevent any form of the disease, the control strategy of leishmaniasis mainly relies on early case detection followed by adequate pharmacological treatment that may improve the prognosis and can reduce transmission. A handful of compounds and formulations are available for the treatment of leishmaniasis in humans, but only few of them are currently in use since most of these agents are associated with toxicity problems such as nephrotoxicity and cardiotoxicity in addition to resistance problems. In recent decades, very few novel drugs, new formulations of standard drugs or combinations of them have been approved against leishmaniasis. This review highlights the current drugs and combinations that are used medical practice and recent advances in new treatments against leishmaniasis that were pointed out in the recent 2nd Conference, Global Challenges in Neglected Tropical Diseases, held in San Juan, Puerto Rico in June 2018, emphasizing the plethora of new families of molecules that are bridging the gap between preclinical and first-in-man trials in next future.

Keywords: drug discovery; neglected tropical diseases; NTD2018; pharmacology; visceral leishmaniasis

Article note

A collection of invited papers based on presentations at the 2nd International Conference on Global Challenges in Neglected Tropical Diseases (NTD2018), San Juan, Puerto Rico, June 25–27 2018.

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About the article

Published Online: 2019-06-11

Published in Print: 2019-08-27


Funding Source: Ministerio de Economía y Competitividad

Award identifier / Grant number: AGL2016-79813-C2-1R

Award identifier / Grant number: SAF2017-83575-R

Financial support from the Ministerio de Economía y Competitividad (MINECO, AEI, FEDER, UE) [MINECO, Funder Id: http://dx.doi.org/10.13039/501100003329, AGL2016-79813-C2-1R and Funder Id: http://dx.doi.org/10.13039/501100003329, SAF2017-83575-R], and the Junta de Castilla y León co-financed by FEDER, UE [LE020P17] is gratefully acknowledged. CGC and BGA are supported by scholarships from the Junta de Castilla y León co-financed by FEDER.


Citation Information: Pure and Applied Chemistry, Volume 91, Issue 8, Pages 1385–1404, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: https://doi.org/10.1515/pac-2018-1102.

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