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Open Physics

formerly Central European Journal of Physics

Editor-in-Chief: Feng, Jonathan

Managing Editor: Lesna-Szreter, Paulina

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Open Access
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Volume 12, Issue 10 (Oct 2014)

Issues

MCNP simulation of the dose distribution in liver cancer treatment for BNC therapy

Dragana Krstic
  • Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia
  • Email:
/ Zoran Jovanovic
  • Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia
  • Email:
/ Vladimir Markovic
  • Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia
  • Email:
/ Dragoslav Nikezic
  • Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia
  • Email:
/ Vlade Urosevic
  • Faculty of Technical Science, University of Kragujevac, Svetog Save 65, 32000, Cacak, Serbia
  • Email:
Published Online: 2014-08-16 | DOI: https://doi.org/10.2478/s11534-014-0507-2

Abstract

The Boron Neutron Capture Therapy (BNCT) is based on selective uptake of boron in tumour tissue compared to the surrounding normal tissue. Infusion of compounds with boron is followed by irradiation with neutrons. Neutron capture on 10B, which gives rise to an alpha particle and recoiled 7Li ion, enables the therapeutic dose to be delivered to tumour tissue while healthy tissue can be spared. Here, therapeutic abilities of BNCT were studied for possible treatment of liver cancer using thermal and epithermal neutron beam. For neutron transport MCNP software was used and doses in organs of interest in ORNL phantom were evaluated. Phantom organs were filled with voxels in order to obtain depth-dose distributions in them. The result suggests that BNCT using an epithermal neutron beam could be applied for liver cancer treatment.

Keywords: Boron Neutron Capture Therapy (BNCT); Monte Carlo simulation; depth-dose distributions; liver cancer

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About the article

Published Online: 2014-08-16

Published in Print: 2014-10-01


Citation Information: Open Physics, ISSN (Online) 2391-5471, DOI: https://doi.org/10.2478/s11534-014-0507-2. Export Citation

© 2014 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

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