Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Open Physics

formerly Central European Journal of Physics

Editor-in-Chief: Seidel, Sally

Managing Editor: Lesna-Szreter, Paulina

1 Issue per year

IMPACT FACTOR 2017: 0.755
5-year IMPACT FACTOR: 0.820

CiteScore 2017: 0.83

SCImago Journal Rank (SJR) 2017: 0.241
Source Normalized Impact per Paper (SNIP) 2017: 0.537

ICV 2017: 162.45

Open Access
See all formats and pricing
More options …
Volume 12, Issue 10


Volume 13 (2015)

MCNP simulation of the dose distribution in liver cancer treatment for BNC therapy

Dragana Krstic / Zoran Jovanovic / Vladimir Markovic / Dragoslav Nikezic / Vlade Urosevic
Published Online: 2014-08-16 | DOI: https://doi.org/10.2478/s11534-014-0507-2


The Boron Neutron Capture Therapy (BNCT) is based on selective uptake of boron in tumour tissue compared to the surrounding normal tissue. Infusion of compounds with boron is followed by irradiation with neutrons. Neutron capture on 10B, which gives rise to an alpha particle and recoiled 7Li ion, enables the therapeutic dose to be delivered to tumour tissue while healthy tissue can be spared. Here, therapeutic abilities of BNCT were studied for possible treatment of liver cancer using thermal and epithermal neutron beam. For neutron transport MCNP software was used and doses in organs of interest in ORNL phantom were evaluated. Phantom organs were filled with voxels in order to obtain depth-dose distributions in them. The result suggests that BNCT using an epithermal neutron beam could be applied for liver cancer treatment.

Keywords: Boron Neutron Capture Therapy (BNCT); Monte Carlo simulation; depth-dose distributions; liver cancer

  • [1] D. L. Bleuel, W. T. Chu, R. J. Donahue, B. A. Ludewigta, J. Vujic, Med. Phys. 25, 1725 (1998) http://dx.doi.org/10.1118/1.598353CrossrefGoogle Scholar

  • [2] F. El Moussaoui, T. El Bardouni, M. Azahra, A. Kamili, H. Boukhal, Cancer/Radiotherapie 12, 360 (2008) http://dx.doi.org/10.1016/j.canrad.2008.03.005CrossrefGoogle Scholar

  • [3] A. Zonta et al., Appl. Radiat. Isot. 67, S67 (2009) http://dx.doi.org/10.1016/j.apradiso.2009.03.087CrossrefGoogle Scholar

  • [4] G. Gambarini, G. G. Daquino, R. L. Moss, M. Carrara, V. A. Nievaart, E. Vanossi, Radiat. Prot. Dosim. 126, 604 (2007) http://dx.doi.org/10.1093/rpd/ncm123CrossrefGoogle Scholar

  • [5] T. Pinelli et al., Eighth International Symposium, 1998, Los Angeles, CA, USA (Kluwer Academic/Plenum Publishers, New York, 2001) 1427 Google Scholar

  • [6] A. Zonta et al., J. Phys.: Conference Series 41, 484 (2006) http://dx.doi.org/10.1088/1742-6596/41/1/054CrossrefGoogle Scholar

  • [7] S. Bortolussi et al., Appl. Radiat. Isot. 69, 1924 (2011) http://dx.doi.org/10.1016/j.apradiso.2011.03.034CrossrefGoogle Scholar

  • [8] L. Kankaanranta et al., Int. J. Radiation Oncol. Biol. Phys. 69, 475 (2007) http://dx.doi.org/10.1016/j.ijrobp.2007.03.039CrossrefGoogle Scholar

  • [9] I. Porras, Phys. Med. Biol. 57, L1 (2008) http://dx.doi.org/10.1088/0031-9155/53/7/L01CrossrefGoogle Scholar

  • [10] I. Porras, Appl. Radiat. Isot. 69, 1838 (2011) http://dx.doi.org/10.1016/j.apradiso.2011.04.002CrossrefGoogle Scholar

  • [11] H. Horiguchi, T. Nakamura, H. Kumada, H. Yanagie, M. Suzuki, H. Sagawa, Appl. Radiat. Isot. 69, 1882 (2011) http://dx.doi.org/10.1016/j.apradiso.2011.03.036CrossrefGoogle Scholar

  • [12] D. Krstic, V. M. Markovic, Z. Jovanovic, B. Milenkovic, D. Nikezic, J. Atanackovic, Radiat. Prot. Dosim. DOI:10.1093/rpd/nct365. CrossrefGoogle Scholar

  • [13] K. F. Eckerman, M. Cristy, J. C. Ryman The ORNL Mathematical Phantom Series, Oak Ridge National Laboratory Report, (Oak Ridge, TN, USA, 1996) Updated 08 April (2009) Google Scholar

  • [14] D. Krstic, D. Nikezic, Comp. Phys. Commun. 176, 33 (2007) http://dx.doi.org/10.1016/j.cpc.2006.06.016CrossrefGoogle Scholar

  • [15] X-5 Monte Carlo Team, MCNP’a General Monte Carlo N-Particle Transport Code, Version 5 Vol. I: Overview and Theory (Los Alamos National Laboratory, Los Alamos, 2003) Google Scholar

  • [16] T. Matsumoto, Nucl. Instrum. Meth. A 580, 552 (2007) http://dx.doi.org/10.1016/j.nima.2007.05.233CrossrefGoogle Scholar

About the article

Published Online: 2014-08-16

Published in Print: 2014-10-01

Citation Information: Open Physics, Volume 12, Issue 10, Pages 714–718, ISSN (Online) 2391-5471, DOI: https://doi.org/10.2478/s11534-014-0507-2.

Export Citation

© 2014 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Comments (0)

Please log in or register to comment.
Log in