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Paladyn, Journal of Behavioral Robotics

Editor-in-Chief: Schöner, Gregor

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2081-4836
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Spatio-temporal dependencies in functional connectivity in rodent cortical cultures

Matthew C. Spencer
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
  • :
/ Julia H. Downes
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
/ Dimitris Xydas
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
/ Mark W. Hammond
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
  • School of Pharmacy, University of Reading, Whiteknights, RG6 6AP, UK
/ Victor M. Becerra
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
/ Benjamin J. Whalley
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
  • School of Pharmacy, University of Reading, Whiteknights, RG6 6AP, UK
/ Kevin Warwick
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
/ Slawomir J. Nasuto
  • Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK
Published Online: 2012-03-12 | DOI: https://doi.org/10.2478/s13230-012-0002-7

Abstract

Models of functional connectivity in cortical cultures on multi-electrodes arrays may aid in understanding how cognitive pathways form and improve techniques that aim to interface with neuronal systems. To enable research on such models, this study uses both data- and model-driven approaches to determine what dependencies are present in and between functional connectivity networks derived from bursts of extracellularly recorded activity. Properties of excitation in bursts were analysed using correlative techniques to assess the degree of linear dependence and then two parallel techniques were used to assess functional connectivity. Three models presenting increasing levels of spatio-temporal dependency were used to capture the dynamics of individual functional connections and their consistencies were verified using surrogate data. By comparing network-wide properties between model generated networks and functional networks from data, complex interdependencies were revealed. This indicates the persistent co-activation of neuronal pathways in spontaneous bursts, as can be found in whole brain structures.

Keywords: functional connectivity; cortical cultures; multi-electrode arrays

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Received: 2011-11-10

Accepted: 2012-01-22

Published Online: 2012-03-12

Published in Print: 2011-09-01


Citation Information: Paladyn, Journal of Behavioral Robotics. Volume 2, Issue 3, Pages 156–163, ISSN (Online) 2081-4836, DOI: https://doi.org/10.2478/s13230-012-0002-7, March 2012

© Matthew C. Spencer et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

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