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Polish Journal of Chemical Technology

The Journal of West Pomeranian University of Technology, Szczecin

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Volume 12, Issue 4 (Jan 2010)

Issues

LiOH.H2O as a catalyst for Knoevenagel and Gewald reactions

Moustafa Gouda
Published Online: 2010-12-28 | DOI: https://doi.org/10.2478/v10026-010-0046-6

LiOH.H2O as a catalyst for Knoevenagel and Gewald reactions

Commercial available lithium hydroxide monohydrate LiOH.H2O was found to be a novel ‘dual activation’ catalyst for tandem cross Knoevenagel condensation between malononitrile or ethylcyanoacetate and aromatic aldehydes leading to an efficient and easy synthesis of the corresponding arylidenes at room temperature in a short reaction time. In the case of salicyaldehyde the reaction lead to the formation of 3-substituted coumarins. The high efficacy, cheapness and easy availability of LiOH.H2O prompted us to investigate its validity as a basic catalyst for Gewald reaction.

Keywords: Malononitrile; Ethylcyanoacetate; Cyclohexanone; LiOH.H2O; Knoevenagel reaction; Gewald reaction

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About the article


Published Online: 2010-12-28

Published in Print: 2010-01-01


Citation Information: Polish Journal of Chemical Technology, ISSN (Online) 1899-4741, ISSN (Print) 1509-8117, DOI: https://doi.org/10.2478/v10026-010-0046-6.

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