Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Polish Journal of Chemical Technology

The Journal of West Pomeranian University of Technology, Szczecin

4 Issues per year


IMPACT FACTOR 2016: 0.725
5-year IMPACT FACTOR: 0.774

CiteScore 2016: 0.76

SCImago Journal Rank (SJR) 2016: 0.262
Source Normalized Impact per Paper (SNIP) 2016: 0.462

Open Access
Online
ISSN
1899-4741
See all formats and pricing
More options …
Volume 19, Issue 1

Issues

Nanospheres caped Pt(II) and Pt (IV): synthesis and evaluation as antimicrobial and Antifungal Agent

Hatice Öğütçü / Nurdan K. Yetim
  • Kırklareli University, Faculty of Arts and Science, Department of Chemistry, Kırklareli, Turkey
  • Gazi University, Faculty of Science, Department of Chemistry, Ankara, 06500, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elvan H. Özkan / Orçun Eren / Gamze Kaya / Nurşen Sarı / Ali Dişli
Published Online: 2017-05-11 | DOI: https://doi.org/10.1515/pjct-2017-0011

Abstract

Antimicrobial and antifungal polymers are gaining the attention of pharmaceutical makers and industrial design. Nanospheres-Polymers attached Platinum(II) / (IV) complexes have been synthesized to investigate antimicrobial activities. Firstly, nanospheres involving Schiff bases were synthesized from (aminomethyl) polystyrene and four substitute salicylaldehyde (2-hydroxy benzaldehyde, 5-fluoro-2-hydroxy benzaldehyde, 5-kloro-2-hydroxy benzaldehyde, 5-bromo-2-hydroxy benzaldehyde). Secondly, polymers attached Platinum(II) / (IV) complexes have been prepared by means of template method. The IR spectra show that the ligands act in a monovalent bidentate fashion all nanospheres involving Schiff bases. Square-planar and octahedral structures are proposed for Pt(II) and Pt(IV), respectively. All these substances have been examined for antibacterial activity against pathogenic strains, and antifungal activity. In particular, Pt(IV) complexes were more potent bactericides than all of the synthesized substances.

Keywords: antimicrobial agent; antifungal agent; poly(styrene); caped platinium

References

  • 1. Liechty, W.B., Kryscio, D.R., Slaughter, B.V. & Peppas, N.A. (2010). Polymers for drug delivery systems. Annu. Rev. Chem. Biomol. Eng. 1, 149-173. DOI: 10.1146/annurev-chembioeng-073009-100847.CrossrefGoogle Scholar

  • 2. Hughes, G.A. (2005). Nanostructure-mediated drug delivery. Nanomed 1, 22-30. DOI: 10.1016/j.nano.2004.11.009.CrossrefGoogle Scholar

  • 3. Kohli, A.K. & Alpar, H.O. (2004). Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge. Int. J. Pharm. 275, 13-17. DOI: 10.1016/ j.ijpharm.2003.10.038.CrossrefGoogle Scholar

  • 4. Abel, E.W., Heard P.J., Orrell, K.G., Hursthouse, M.B. & Mazid, M.A. (1993). Halogenotrimethylplatinum (IV) complexes of 2,6-bis(p-tolylthiomethyl) pyridine (L1): nuclear magnetic resonance studies of their solution state stereodynamics and the crystal structure of fac-[PtBrMe3L1]: J. Chem. Soc. Dalton Trans. 4, 3795-3801. DOI: 10.1039/DT9930003795.CrossrefGoogle Scholar

  • 5. Abel, E.W., Orrell, K.G., Osborne, A.G., Pain, H.M., Sik, V., Hursthouse, M.B. & Malik, K.M.A. (1994). 2,2’:6’,2’’-Terpyridine( terpy) acting as a fl uxional bidentate ligand. Part 4.cis-[m(c6f5)(2)(terpy)] (m= pd or pt)-nuclear-magnetic-resonance studies of their solutiondynamics and crystal-structure of cis-[pd(c6f5)(2)(terpy)]. J. Chem. Soc., Dalton Trans. 23, 3441-3449. DOI: 10.1039/DT9940003441.CrossrefGoogle Scholar

  • 6. Yam, V.W.W., Tang, R.P.L., Wong, K.M.C. & Cheung, K.K. (2001) Synthesis, luminescence, electrochemistry and ion- -binding studies of platinum(II)terpyridyl acetylide complexes. Organomet. 20, 4476-4482. DOI: 10.1021/om010336x.CrossrefGoogle Scholar

  • 7. Yam, V.W.W., Chan, K.H.Y., Wong, K.M.C. & Zhu, N.Y. (2005). Luminescent platinum(II) terpyridyl complexes: Effect of counter ions on solvent-induced aggregation and color changes. Eur. J. Chem. 11, 4535-4543. DOI: 10.1002/chem.200500106.CrossrefGoogle Scholar

  • 8. Pratesi, G., Perego, P., Polizzi, D., Righetti, S.C., Supino, R., Caserini, C., Manzotti, C., Giuliana, F.C., Pezzoni, G., Spinelli, S., Farrell, N. & Zunino, F.Br. (1999). A novel charges trinuclear platinum complex effective against cisplatin-resistant tumours, hypersensitivity of p53-mutant human tumour xenografts. J. Cancer 80, 1912-1919. DOI: 10.1038/sj.bjc.6690620.CrossrefGoogle Scholar

  • 9. Kelland, L.R., Sharp, S.Y., O’Neill, C.F., Raynaud, F.I., Beale, P.J. & Judson, I.R. (1999). Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance. J. Inorg Biochem. 77, 111-115. DOI: 10.1016/ S0162-0134(99)00141-5.CrossrefGoogle Scholar

  • 10. Orlandi, L., Colella, G., Bearzatto, A., Abolafio, G., Manzotti, L., Daidone, M.G. & Zaffaroni, N. (2001). Effects of a novel trinuclear platinum complex in cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines: interference with cell cycle progression and induction of apoptosis. Eur. J. Cancer. 37, 649-659. DOI: 10.1016/S0959-8049(00)00445-7.CrossrefGoogle Scholar

  • 11. Wheate N.J. & Collins, J.G. (2003). Multi-nuclear platinum complexes as anti-cancer drugs. Coord. Chem. Rev. 241, 133-145. DOI: 10.1016/S0010-8545(03)00050-X.CrossrefGoogle Scholar

  • 12. Ahmedi, T.S., Wang, Z.L., Green, T.C., Henglein, A. & El-Sayed, M.A. (1996). Shape- controlled synthesis of colloidal platinum nanoparticles. Science 272, 1924-1925. DOI: 10.1126/ science.272.5270.1924.CrossrefGoogle Scholar

  • 13. Algül, O., Ozçelik, B., Abbasoğlu, U. & Gümüş, F. (2005). Synthesis, characterization and genotoxicity of platinum(II) complexes with substituted. Turk. J. Chem. 29, 607-615.Google Scholar

  • 14. Herricks, T., Chen, J.Y., Xia, Y.N. (2004). Polyol synthesis of platinum nanoparticles: control of morphology with sodium nitrate. Nano Lett. 4, 2367-2371.CrossrefGoogle Scholar

  • 15. Asharani, P.V., Xinyi, N., Prakash, H.M. & Valiyaveettil, S. (2010). DNA damage and p53 - mediated growth arrest in human cells treated with platinum nanoparticles. Nanomed 5, 51-64. DOI: 10.1021/nl048570a.CrossrefGoogle Scholar

  • 16. Sarı, N. & Yüzüak, N. (2006). Synthesis, characterization of novel polymeric schiff bases their complexes. J. Inorg. Organomet. Polym. Mater. 16, 259-264. DOI: 10.1007/s10904-006-9056-5.CrossrefGoogle Scholar

  • 17. Gopal, J., Hasan, N., Manikandan, M. & Wu, H.F. (2013). Bacterial toxicity/compatibility of platinum nanospheres, nanocuboids and nanofl ower. Sci. Rep. 3, 1260. DOI: 10.1038/ srep01260.CrossrefGoogle Scholar

  • 18. Nartop, D. & Sarı, N. (2012). Novel Poly(styrene) attached Schiff Bases for uptake Mn(II) and Ni(II)ions and as antimicrobial agent against micrococcus luteus. J. Inorg. Organomet. Polym. 22, 772-779. DOI: 10.1007/s10904-011-9634-z.Web of ScienceCrossrefGoogle Scholar

  • 19. Sarı, N., Pişkin, N., Öğütcü, H. & Kurnaz, N. (2013). Spectroscopic characterization of novel D-aminoacid-Schiff bases and their Cr(III) and Ni(II) complexes as antimicrobial agents. Med. Chem. Res. 22, 580-587. DOI: 10.1007/s00044-012-0039-5.CrossrefGoogle Scholar

  • 20. Bozkır, E., Sari, N. & Öğütçü, H. (2012). Polystyrene containing carbinolamine/azomethine potentially useful as antimicrobial agent synthesis and biological evaluation. J. Inorg. Organomet. Polym. Mater. 22, 1146-1155. DOI: 10.1007/ s10904-012-9697-5.CrossrefWeb of ScienceGoogle Scholar

  • 21. Swihart, D.L. & Mason, W.R. (1970). Electronic spectra of octahedral platinum (IV) complexes. Inorg. Chem. 9, 1749-1757. DOI: 10.1021/ic50089a029.CrossrefGoogle Scholar

  • 22. Keland, L.R., Mistry, P., Abel, G., Loh, S.Y., O’Neil, C.F., Murer, B.A. & Harrap, K.R. (1992). Mechanism-related circumvention of acquired cis- diamminedichloroplatinum (II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates. Cancer Res. 52, 3857-3864.Google Scholar

About the article

Published Online: 2017-05-11

Published in Print: 2017-03-28


Citation Information: Polish Journal of Chemical Technology, Volume 19, Issue 1, Pages 74–80, ISSN (Online) 1899-4741, DOI: https://doi.org/10.1515/pjct-2017-0011.

Export Citation

© by Nurşen Sarı. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

Comments (0)

Please log in or register to comment.
Log in