2. Kędra B, Popiela T, Sierzega M et al.: Prognostic factors of long-term survival after resective procedures for pancreatic cancer. Hepatogastroenterol 2001; 48(42): 1762-66.Google Scholar
3. Tomimaru Y, Yano M, Takachi K et al.: Plasma D-dimer levels show correlation with number of lymph node metastases in patients with esophageal cancer. J Am Coll Surg 2006; 202: 139-45.Google Scholar
4. Yamashita H, Kitayama J, Kanno N et al.: Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. BMC Cancer 2006; 6: 147.CrossrefGoogle Scholar
5. Gadducci A, Baicchi U, Marrai R et al.: Pretreatment plasma levels of and von Willebrand factor (vWF) in patients with operable cervical cancer: influence of surgical-pathological stage, tumor size, histologic type, and lymph node status. GynecolOncol 1993; 49: 354-58.Google Scholar
6. Dirix LY, Salgado R, Weytjens R et al.: Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with 700 metastatic breast cancer. Br J Cancer 2002; 86: 389-95.Google Scholar
7. Lee JH, Ryu KW, Kim S et al.: Preoperative plasma fibrinogen levels in gastric cancer patients correlate with extent of tumor. Hepatogastroenterol 2004; 51: 1860-63.Google Scholar
8. Roche Y, Pasquier D, Rambeaud JJ et al.: Fibrinogen mediates bladder cancer cell migration in an ICAM-1-dependent pathway. Thromb Haemost 2003; 89: 1089-97.Google Scholar
9. O’Meara RA: Coagulative properties of cancers. Ir J Med Sci 1958; 394: 474-79.Google Scholar
10. Iwasaki T: Histological and experimental observations on the destruction of tumour cells the blood vessels. J Path Bact 1915; 20: 85.Google Scholar
12. Piccioli A, Falanga A, Baccaglini U et al.: Cancer and venous thromboembolism. Semin ThrombHemost 2006; 32: 694-99.Google Scholar
13. Blomback B, Hessel B, Hogg D et al.: A two-step fibrinogen-fibrin transition in blood coagulation. Nature 1978; 275: 501-05.Google Scholar
15. Rege KP, Jones S, Day J et al.: In proven deep vein thrombosis, a low positive D-Dimer score is a strong negative predictor for associated malignancy. Thromb Haemost 2004; 91: 1219-22.Google Scholar
16. Paneesha S, Cheyne E, French K et al.: High D-dimer levels at presentation in patients with venous thromboembolism is a marker of adverse clinical outcomes. Br J Haematol 2006; 135: 85-90.CrossrefGoogle Scholar
18. Wang ZH, Chang CC, Tai CJ: Deep vein thrombosis and pulmonary embolism in pancreatic cancer. J Cancer Res Pract 2011; 27 (4): 171-76.Google Scholar
20. Xu G, Zhang YL, Huang W: Relationship between plasma D-dimer levels and clinicopathologic parameters in resectable colorectal cancer patients. World J Gastroenterol 2004; 10: 922-23.PubMedGoogle Scholar
24. Palumbo JS, Talmage KE , Massari JV et al.: Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 2005; 105(1): 178-85.CrossrefPubMedGoogle Scholar
25. Darwish AA, Sokal E, Stephenne X et al.: Permanent access to the portal system for cellular transplantation using an implantable port device. Liver Transpl 2004; 10: 1213-15.PubMedCrossrefGoogle Scholar
26. Hogendorf P, Durczyński A, Kumor A et al.: Prostaglandin E2 (PGE2) in portal blood in patients with pancreatic tumor - a single institution series. J Invest Surg 2012; 25(1): 8-13.CrossrefPubMedGoogle Scholar
27. Shibata T, Magari Y, Kamberi P et al.: Significance of urinary fibrin/fibrinogen degradation products (FDP) D-dimer measured by a highly sensitive ELISA method with a new monoclonal antibody (D-D E72) in various renal diseases. ClinNephrol 1995; 44(2): 91-95.Google Scholar
28. Spadaro A, Tortorella V, Morace C et al.: High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis. World J Gastroenterol 2008; 14(10): 1549-52.PubMedCrossrefGoogle Scholar
29. Wang HY, Xiu DR, Li ZF et al.: Coagulation function in patients with pancreatic carcinoma. Chin Med J (Engl). 2009; 122(6): 697-700. Google Scholar
Polish Journal of Surgery
The Journal of Foundation of the Polish Journal of Surgery
12 Issues per year
CiteScore 2016: 0.29
SCImago Journal Rank (SJR) 2016: 0.166
Source Normalized Impact per Paper (SNIP) 2016: 0.207
Very High Concentration of D-Dimers in Portal Blood in Patients with Pancreatic Cancer
The aim of the study
Nowadays, increasing attention has been focused on relation between increased D-dimer levels and cancer among patients without detectable thrombosis.
was to measure plasma D-dimer levels in portal and peripheral blood in pancreatic cancer patients with absence of venous thromboembolism.
Material and methods. Fifteen consecutive patients hospitalized in the Department of General and Transplant Surgery of Medical University in Łódź, from January to March 2012 who underwent surgery due to a pancreatic cancer were enrolled. At laparotomy, portal and peripheral blood were sampled concurrently. D-dimer and fibrinogen levels were measured. Moreover, to investigate overall coagulation function prothrombin time (PT), prothrombin index (PI), international normalized ratio (INR), thrombin time (TT), activated partial thromboplastin time (APTT), TT and APTT index were evaluated.
Results. Peripheral plasma D-dimmer levels above normal range were found in 10/15 patients (66,67%), whereas D-dimer above normal values were confirmed in all portal blood samples. Mean D-dimer values were higher in portal than in peripheral blood (3279.37 vs 824.64, by 297%, p=0,025). These discrepancies were accompanied by normal limits of portal and peripheral levels of fibrinogen and comparable coagulation function indexes.
Conclusion. Our preliminary study showed the close relation between activation of hemostasis, reflected by elevated D-dimers in portal blood and presence of pancreatic cancer. These data suggest that measurement of portal blood D-dimer levels may be a potentially useful technique for screening the pancreatic cancer.