Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Polish Journal of Surgery

The Journal of Foundation of the Polish Journal of Surgery

12 Issues per year

CiteScore 2016: 0.29

SCImago Journal Rank (SJR) 2016: 0.166
Source Normalized Impact per Paper (SNIP) 2016: 0.207

Open Access
See all formats and pricing
More options …
Volume 84, Issue 7


Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer

Violetta Sulżyc-Bielicka / Lidia Kołodziejczyk / Sylwia Jaczewska / Dariusz Bielicki / Józef Kładny / Krzysztof Safranow
Published Online: 2012-08-30 | DOI: https://doi.org/10.2478/v10035-012-0058-4

Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer

Parasitic protozoans of the Cryptosporidium genus are intracellular intestinal parasites of mammals, causing cryptosporidiosis. Clinically, cryptosporidiosis manifests as chronic diarrhoea. Individuals with immune disorders, including those with neoplasms, are at risk of symptomatic invasion.

The aim of the study was the evaluation of Cryptosporidium sp. prevalence in patients with diagnosed colorectal cancer.

Material and methods. The studied group encompassed 87 patients with diagnosed colorectal cancer, undergoing surgery at the Department of General and Oncological Surgery, Pomeranian Medical University, in the years 2009-2010. Immunoenzymatic tests for Cryptosporidium sp. on faeces samples were performed with the use of commercial test kit, ProSpecT®Cryptosporidium Microplate Assay (Remel Inc).

Results. The presence of Cryptosporidium sp. was found in 12.6% of studied patients with colorectal cancer. The performed statistical analysis did not reveal any correlation between Cryptosporidium sp. infection and gender, age, neoplasm advancement stage as per Astler-Coller scale, neoplasm differentiation grade, or neoplastic tumour localisation in relation to the splenic flexure.

Conclusions. There was found high prevalence of Cryptosporidium sp. in patients with colorectal cancer. It was comparable to the prevalence reported for patients with immune deficiency.

Keywords: Cryptosporidium; colorectal cancer

  • Nime FA, Burek JD, Page DL et al.: Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology 1976; 70: 592-98.Google Scholar

  • Muhid A, Robertson I, Ng J et al.: Prevalence of and management factors contributing to Cryptosporidium sp. infection in pre-weaned and postweaned calves in Johor, Malaysia. Exp Parasitol 2011; 127: 534-38.CrossrefWeb of ScienceGoogle Scholar

  • Smith HV, Rose JB: Waterborne cryptosporidiosis: current status. Parasitol Today 1998; 14: 14-22.PubMedCrossrefGoogle Scholar

  • Chen XM, Keithly JS, Paya CV et al.: Cryptosporidiosis. N Engl J Med 2002; 346): 1723-31.Google Scholar

  • Ballal M, Prabhu T, Chandran A et al.: Cryptosporidium and isospora belli diarrhoea in immunocompromised hosts. Indian J Cancer 1999; 36: 38-42.PubMedGoogle Scholar

  • Baqai R, Anwar S, Kazmi SU: Detection of cryptosporidium in immunosuppressed patients. J Ayub Med Coll Abbottabad 2005; 17: 38-40.Google Scholar

  • Chaisson RE, Gallant JE, Keruly JC et al.: Impact of opportunistic disease on survival in patients with HIV infection. AIDS 1998; 12: 29-33.CrossrefPubMedGoogle Scholar

  • Manabe YC, Clark DP, Moore RD et al.: Cryptosporidiosis in patients with AIDS: correlates of disease and survival. Clin Infect Dis 1998; 27: 536-42.PubMedCrossrefGoogle Scholar

  • O'Connor RM, Shaffie R, Kang G et al.: Cryptosporidiosis in patients with HIV/AIDS. AIDS 2011; 25: 549-60.Google Scholar

  • Grzeszczuk A, Kalinowska A: Diagnostics of cryptosporidiosis - own experience. Wiad Parazytol 1998; 44: 311.Google Scholar

  • Majewska AC, Sulima P, Werner A i wsp.: Cryptosporidiosis in HIV-positive patients. Wiad Parazytol 1999; 45: 125-28.Google Scholar

  • Certad G, Ngouanesavanh T, Guyot K et al.: Cryptosporidium parvum, a potential cause of colic adenocarcinoma. Infect Agent Cancer 2007; 2: 22.PubMedCrossrefGoogle Scholar

  • Benamrouz S, Conseil V, Creusy C et al.: Parasites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa). Parasite 2012; (w druku).Web of ScienceGoogle Scholar

  • Certad G, Creusy C, Guyot K et al.: Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain. Int J Parasitol 2010; 40: 1469-75.Web of ScienceCrossrefGoogle Scholar

  • Certad G, Benamrouz S, Guyot K et al.: Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. Appl Environ Microbiol 2012; 78: 1746-51.CrossrefWeb of ScienceGoogle Scholar

  • Bajer A, Bednarska M, Siński E: Cryptosporidium spp. And Giardia spp.-enviromental studies in Poland. Wiad Parazytol 2009; 55: 301-04.Google Scholar

  • Bajer A, Bednarska M, Cacciò SM i wsp: Genotyping of Cryptosporidium isolates from human clinical cases in Poland. Parasitol Res 2008; 103: 37-42.CrossrefGoogle Scholar

  • Sulżyc-Bielicka V, Kuźna-Grygiel W, Kołodziejczyk L et al.: Cryptosporidiosis in patients with colorectal cancer. J Parasitol 2007; 93: 722-24.Web of ScienceCrossrefGoogle Scholar

  • Sreedharan A, Jayshree RS, Sridhar H: Cryptosporidiosis among cancer patients: an observation. J Diarrhoeal Dis Res 1996; 14: 211-13PubMedGoogle Scholar

  • Rudrapatna JS, Kumar V, Sridhar H: Intestinal parasitic infections in patients with malignancy. J Diarrhoeal Dis Res 1997; 15: 71-74.PubMedGoogle Scholar

  • de Martel C, Franceschi S: Infections and cancer: established associations and new hypotheses. Crit Rev Oncol Hematol 2009; 70: 183-94.CrossrefGoogle Scholar

  • Zur Hausen H: The search for infectious causes of human cancers: where and why. Virology 2009; 392: 1-10.Web of ScienceGoogle Scholar

  • Pagano JS, Blaser M, Buendia MA et al.: Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol 2004; 14: 453-71.CrossrefGoogle Scholar

  • Fried B, Reddy A, Mayer D: Helminths in human carcinogenesis. Cancer Lett 2011; 305: 239-49.Web of ScienceGoogle Scholar

  • Liu J, Deng M, Lancto CA: Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells. Infect Immun 2009; 77: 837-49.PubMedCrossrefWeb of ScienceGoogle Scholar

  • Mele R, Gomez Morales MA, Tosini F et al.: Cryptosporidium parvum at different developmental stages modulates host cell apoptosis in vitro. Infect Immun. 2004; 72: 6061-67.PubMedCrossrefGoogle Scholar

About the article

Published Online: 2012-08-30

Published in Print: 2012-07-01

Citation Information: Polish Journal of Surgery, Volume 84, Issue 7, Pages 348–351, ISSN (Print) 0032-373X, DOI: https://doi.org/10.2478/v10035-012-0058-4.

Export Citation

This content is open access.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Zeynep Tas Cengiz, Hasan Yilmaz, Ibrahim Halil Sahin, Mahir Kapmaz, and Pinar Ekici
Jundishapur Journal of Microbiology, 2016, Volume 10, Number 2
Sim Sai Tin and Viroj Wiwanitkit
Annals of Colorectal Research, 2015, Volume 3, Number 3
Sim Sai Tin and Viroj Wiwanitkit
Annals of Colorectal Research, 2015, Volume 3, Number 3
Maulilio John Kipanyula, Paul Faustin Seke Etet, Lorella Vecchio, Mohammed Farahna, Elias Nchiwan Nukenine, and Armel Hervé Nwabo Kamdje
Cellular Signalling, 2013, Volume 25, Number 2, Page 403

Comments (0)

Please log in or register to comment.
Log in