Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Polish Journal of Surgery

The Journal of Foundation of the Polish Journal of Surgery

12 Issues per year

CiteScore 2016: 0.29

SCImago Journal Rank (SJR) 2015: 0.214
Source Normalized Impact per Paper (SNIP) 2015: 0.336

Open Access
See all formats and pricing
In This Section
Volume 84, Issue 7 (Jul 2012)


Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer

Violetta Sulżyc-Bielicka
  • Department of Clinical Oncology, Pomeranian Medical University
/ Lidia Kołodziejczyk
  • Chair and Department of Biology and Medical Parasitology, Pomeranian Medical University
/ Sylwia Jaczewska
  • Department of Clinical Oncology, Pomeranian Medical University
/ Dariusz Bielicki
  • Department of Gastroenterology, Pomeranian Medical University
/ Józef Kładny
  • Department of General and Oncological Surgery, Pomeranian Medical University
/ Krzysztof Safranow
  • Biochemistry and Medical Chemistry
Published Online: 2012-08-30 | DOI: https://doi.org/10.2478/v10035-012-0058-4

Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer

Parasitic protozoans of the Cryptosporidium genus are intracellular intestinal parasites of mammals, causing cryptosporidiosis. Clinically, cryptosporidiosis manifests as chronic diarrhoea. Individuals with immune disorders, including those with neoplasms, are at risk of symptomatic invasion.

The aim of the study was the evaluation of Cryptosporidium sp. prevalence in patients with diagnosed colorectal cancer.

Material and methods. The studied group encompassed 87 patients with diagnosed colorectal cancer, undergoing surgery at the Department of General and Oncological Surgery, Pomeranian Medical University, in the years 2009-2010. Immunoenzymatic tests for Cryptosporidium sp. on faeces samples were performed with the use of commercial test kit, ProSpecT®Cryptosporidium Microplate Assay (Remel Inc).

Results. The presence of Cryptosporidium sp. was found in 12.6% of studied patients with colorectal cancer. The performed statistical analysis did not reveal any correlation between Cryptosporidium sp. infection and gender, age, neoplasm advancement stage as per Astler-Coller scale, neoplasm differentiation grade, or neoplastic tumour localisation in relation to the splenic flexure.

Conclusions. There was found high prevalence of Cryptosporidium sp. in patients with colorectal cancer. It was comparable to the prevalence reported for patients with immune deficiency.

Keywords: Cryptosporidium; colorectal cancer

  • Nime FA, Burek JD, Page DL et al.: Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology 1976; 70: 592-98.

  • Muhid A, Robertson I, Ng J et al.: Prevalence of and management factors contributing to Cryptosporidium sp. infection in pre-weaned and postweaned calves in Johor, Malaysia. Exp Parasitol 2011; 127: 534-38. [Crossref] [Web of Science]

  • Smith HV, Rose JB: Waterborne cryptosporidiosis: current status. Parasitol Today 1998; 14: 14-22. [PubMed] [Crossref]

  • Chen XM, Keithly JS, Paya CV et al.: Cryptosporidiosis. N Engl J Med 2002; 346): 1723-31.

  • Ballal M, Prabhu T, Chandran A et al.: Cryptosporidium and isospora belli diarrhoea in immunocompromised hosts. Indian J Cancer 1999; 36: 38-42. [PubMed]

  • Baqai R, Anwar S, Kazmi SU: Detection of cryptosporidium in immunosuppressed patients. J Ayub Med Coll Abbottabad 2005; 17: 38-40.

  • Chaisson RE, Gallant JE, Keruly JC et al.: Impact of opportunistic disease on survival in patients with HIV infection. AIDS 1998; 12: 29-33. [Crossref] [PubMed]

  • Manabe YC, Clark DP, Moore RD et al.: Cryptosporidiosis in patients with AIDS: correlates of disease and survival. Clin Infect Dis 1998; 27: 536-42. [PubMed] [Crossref]

  • O'Connor RM, Shaffie R, Kang G et al.: Cryptosporidiosis in patients with HIV/AIDS. AIDS 2011; 25: 549-60.

  • Grzeszczuk A, Kalinowska A: Diagnostics of cryptosporidiosis - own experience. Wiad Parazytol 1998; 44: 311.

  • Majewska AC, Sulima P, Werner A i wsp.: Cryptosporidiosis in HIV-positive patients. Wiad Parazytol 1999; 45: 125-28.

  • Certad G, Ngouanesavanh T, Guyot K et al.: Cryptosporidium parvum, a potential cause of colic adenocarcinoma. Infect Agent Cancer 2007; 2: 22. [PubMed] [Crossref]

  • Benamrouz S, Conseil V, Creusy C et al.: Parasites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa). Parasite 2012; (w druku). [Web of Science]

  • Certad G, Creusy C, Guyot K et al.: Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain. Int J Parasitol 2010; 40: 1469-75. [Web of Science] [Crossref]

  • Certad G, Benamrouz S, Guyot K et al.: Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. Appl Environ Microbiol 2012; 78: 1746-51. [Crossref] [Web of Science]

  • Bajer A, Bednarska M, Siński E: Cryptosporidium spp. And Giardia spp.-enviromental studies in Poland. Wiad Parazytol 2009; 55: 301-04.

  • Bajer A, Bednarska M, Cacciò SM i wsp: Genotyping of Cryptosporidium isolates from human clinical cases in Poland. Parasitol Res 2008; 103: 37-42. [Crossref]

  • Sulżyc-Bielicka V, Kuźna-Grygiel W, Kołodziejczyk L et al.: Cryptosporidiosis in patients with colorectal cancer. J Parasitol 2007; 93: 722-24. [Web of Science] [Crossref]

  • Sreedharan A, Jayshree RS, Sridhar H: Cryptosporidiosis among cancer patients: an observation. J Diarrhoeal Dis Res 1996; 14: 211-13 [PubMed]

  • Rudrapatna JS, Kumar V, Sridhar H: Intestinal parasitic infections in patients with malignancy. J Diarrhoeal Dis Res 1997; 15: 71-74. [PubMed]

  • de Martel C, Franceschi S: Infections and cancer: established associations and new hypotheses. Crit Rev Oncol Hematol 2009; 70: 183-94. [Crossref]

  • Zur Hausen H: The search for infectious causes of human cancers: where and why. Virology 2009; 392: 1-10. [Web of Science]

  • Pagano JS, Blaser M, Buendia MA et al.: Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol 2004; 14: 453-71. [Crossref]

  • Fried B, Reddy A, Mayer D: Helminths in human carcinogenesis. Cancer Lett 2011; 305: 239-49. [Web of Science]

  • Liu J, Deng M, Lancto CA: Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells. Infect Immun 2009; 77: 837-49. [PubMed] [Crossref] [Web of Science]

  • Mele R, Gomez Morales MA, Tosini F et al.: Cryptosporidium parvum at different developmental stages modulates host cell apoptosis in vitro. Infect Immun. 2004; 72: 6061-67. [PubMed] [Crossref]

About the article

Published Online: 2012-08-30

Published in Print: 2012-07-01

Citation Information: Polish Journal of Surgery, ISSN (Print) 0032-373X, DOI: https://doi.org/10.2478/v10035-012-0058-4. Export Citation

This content is open access.

Comments (0)

Please log in or register to comment.
Log in