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Photonics & Lasers in Medicine


CiteScore 2016: 0.64

SCImago Journal Rank (SJR) 2016: 0.230
Source Normalized Impact per Paper (SNIP) 2016: 0.291

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2193-0643
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Experimental validation of image contrast correlation between ultra-small-angle X-ray scattering and grating-based dark-field imaging using a laser-driven compact X-ray source

Experimentelle Verifizierung des Zusammenhangs zwischen Röntgen-Kleinwinkelstreuung und gitter-basierter Röntgen-Dunkelfeldbildgebung unter Verwendung eines laser-getriebenen Kompaktsynchrotrons

Martin Bech
  • Department of Physics and Institute for Medical Engineering (IMETUM), Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany
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/ Simone Schleede
  • Department of Physics and Institute for Medical Engineering (IMETUM), Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany
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/ Guillaume Potdevin
  • Department of Physics and Institute for Medical Engineering (IMETUM), Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany
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/ Klaus Achterhold
  • Department of Physics and Institute for Medical Engineering (IMETUM), Technische Universität München, James-Franck-Strasse 1, 85748 Garching, Germany
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/ Oliver Bunk / Torben H. Jensen / Rod Loewen / Ron Ruth
  • Lyncean Technologies Inc., 370 Portage Avenue, Palo Alto, CA 94306, USA
  • Stanford Linear Accelerator Center, 2575 Sand Hill Road, Menlo Park, CA 94025, USA
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/ Franz Pfeiffer

Abstract

X-ray phase and dark-field contrast have recently been the source of much attention in the field of X-ray imaging, as they both contribute new imaging signals based on physical principles that differ from conventional X-ray imaging. With a so-called Talbot grating interferometer, both phase-contrast and dark-field images are obtained simultaneously with the conventional attenuation-based X-ray image, providing three complementary image modalities that are intrinsically registered. Whereas the physical contrast mechanisms behind attenuation and phase contrast are well understood, a formalism to describe the dark-field signal is still in progress. In this article, we report on correlative experimental results obtained with a grating interferometer and with small-angle X-ray scattering. Furthermore, we use a proposed model to quantitatively describe the results, which could be of great importance for future clinical and biomedical applications of grating-based X-ray imaging.

Zusammenfassung

Die Röntgen-Bildkontrastierung mittels Phasen- und Dunkelfeld-Kontrast hat in der jüngsten Zeit besonderes Interesse erfahren, da diese Verfahren intrinsisch unterschied­liche physikalische Wechselwirkungen als Bildsignale benut­zen. Mittels eines sogenannten Talbot-Interferometers werden Phasen- und Dunkelfeld-Kontrastaufnahmen gleichzeitig zusammen mit der konventionellen, abschwächungsbasierten Röntgenaufnahme erzeugt, was multimodale Röntgenbilder erlaubt, die intrinsisch registriert sind. Während die physikalischen Prozesse, die den konventionellen Röntgenaufnahmen und den Röntgen-Phasenkontrastaufnahmen zugrunde liegen gut verstanden sind, ist ein entsprechender Formalismus für die Dunkelfeldbildgebung noch in der Erforschung. In dieser Arbeit präsentieren wir experimentelle Ergebnisse, die den Zusammenhang zwischen Röntgen-Kleinwinkelstreuung und gitter-basierter Röntgen-Dunkelfeldbildgebung unter Verwendung eines laser-getriebenen Kompaktsynchrotrons unterstreichen und die für spätere klinische und biomedizini­sche Anwendungen von Bedeutung sein können.

Keywords: X-ray; phase contrast; dark-field; inverse Compton; Dunkelfeld; Laser-generierte Röntgenstrahlung; Phasenkontrast; Röntgenbildgebung; Synchrotron

About the article

Corresponding author


Received: 2011-11-04

Revised: 2011-12-05

Accepted: 2011-12-08

Published in Print: 2012-02-01


Citation Information: Photonics & Lasers in Medicine, ISSN (Online) 2193-0643, ISSN (Print) 2193-0635, DOI: https://doi.org/10.1515/plm-2011-0012.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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[1]
Christoph Jud, Eva Braig, Martin Dierolf, Elena Eggl, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Ernst Rummeny, Peter Noël, Franz Pfeiffer, and Daniela Muenzel
Scientific Reports, 2017, Volume 7, Number 1
[2]
Felix G. Meinel, Felix Schwab, Simone Schleede, Martin Bech, Julia Herzen, Klaus Achterhold, Sigrid Auweter, Fabian Bamberg, Ali Ö. Yildirim, Alexander Bohla, Oliver Eickelberg, Rod Loewen, Martin Gifford, Ronald Ruth, Maximilian F. Reiser, Franz Pfeiffer, Konstantin Nikolaou, and Christian Taube
PLoS ONE, 2013, Volume 8, Number 3, Page e59526
[3]
Elena Eggl, Simone Schleede, Martin Bech, Klaus Achterhold, Roderick Loewen, Ronald D. Ruth, and Franz Pfeiffer
Proceedings of the National Academy of Sciences, 2015, Volume 112, Number 18, Page 5567
[4]
C. Grünzweig, J. Kopecek, B. Betz, A. Kaestner, K. Jefimovs, J. Kohlbrecher, U. Gasser, O. Bunk, C. David, E. Lehmann, T. Donath, and F. Pfeiffer
Physical Review B, 2013, Volume 88, Number 12
[5]
Felix G. Meinel, Felix Schwab, Andre Yaroshenko, Astrid Velroyen, Martin Bech, Katharina Hellbach, Jeanette Fuchs, Thorsten Stiewe, Ali Ö. Yildirim, Fabian Bamberg, Maximilian F. Reiser, Franz Pfeiffer, and Konstantin Nikolaou
Physica Medica, 2014, Volume 30, Number 3, Page 352
[6]
Balša Terzić, Kirsten Deitrick, Alicia S. Hofler, and Geoffrey A. Krafft
Physical Review Letters, 2014, Volume 112, Number 7
[7]
Andre Yaroshenko, Felix G. Meinel, Martin Bech, Arne Tapfer, Astrid Velroyen, Simone Schleede, Sigrid Auweter, Alexander Bohla, Ali Ö. Yildirim, Konstantin Nikolaou, Fabian Bamberg, Oliver Eickelberg, Maximilian F. Reiser, and Franz Pfeiffer
Radiology, 2013, Volume 269, Number 2, Page 427
[8]
F. Schwab, S. Schleede, D. Hahn, M. Bech, J. Herzen, S. Auweter, F. Bamberg, K. Achterhold, A.Ö. Yildirim, A. Bohla, O. Eickelberg, R. Loewen, M. Gifford, R. Ruth, M.F. Reiser, K. Nikolaou, F. Pfeiffer, and F.G. Meinel
Zeitschrift für Medizinische Physik, 2013, Volume 23, Number 3, Page 236

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