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Photonics & Lasers in Medicine


SCImago Journal Rank (SJR) 2018: 0.162
Source Normalized Impact per Paper (SNIP) 2018: 0.346

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Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light

Low-Level-Laser (Licht)-Therapie an Muskelgewebe – Möglichkeiten zur Verbesserung der Leistungsfähigkeit und zur Behandlung von Muskelermüdung und Muskelverletzungen

Cleber Ferraresi
  • Laboratory of Electro-thermo-phototherapy, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil
  • Department of Biotechnology, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michael R. Hamblin
  • Corresponding author
  • Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
  • Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA
  • Harvard-MIT Division of Health Science and Technology, Cambridge, MA 02139, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nivaldo A. Parizotto
  • Laboratory of Electro-thermo-phototherapy, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil
  • Department of Biotechnology, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil
  • Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-11-08 | DOI: https://doi.org/10.1515/plm-2012-0032

Abstract

The use of low level laser (light) therapy (LLLT) has recently expanded to cover areas of medicine that were not previously thought of as the usual applications such as wound healing and inflammatory orthopedic conditions. One of these novel application areas is LLLT for muscle fatigue and muscle injury. Since it is becoming agreed that mitochondria are the principal photoacceptors present inside cells, and it is known that muscle cells are exceptionally rich in mitochondria, this suggests that LLLT should be highly beneficial in muscle injuries. The ability of LLLT to stimulate stem cells and progenitor cells means that muscle satellite cells may respond well to LLLT and help muscle repair. Furthermore the ability of LLLT to reduce inflammation and lessen oxidative stress is also beneficial in cases of muscle fatigue and injury. This review covers the literature relating to LLLT and muscles in both preclinical animal experiments and human clinical studies. Athletes, people with injured muscles, and patients with Duchenne muscular dystrophy may all benefit.

Zusammenfassung

Die Anwendung der Low-Level-Laser (Licht)-Therapie (LLLT) hat sich in letzter Zeit um Bereiche der Medizin erweitert die über die üblichen Anwendungen wie Wundheilung und Behandlung von entzündlichen orthopädischen Leiden hinausgehen. Einen solchen neuen Bereich stellt der Einsatz der LLLT bei Muskelermüdung und Muskelverletzung dar. Seit es Konsens ist, dass die Mitochondrien die wichtigsten Photoakzeptoren innerhalb einer Zelle darstellen, und es bekannt ist, dass Muskelzellen besonders reich an Mitochondrien sind, hat sich die Idee entwickelt, dass die LLLT auch bei Muskelverletzungen nutzbringend eingesetzt werden könnte. Da es möglich ist, Stammzellen und Vorläuferzellen mittels LLLT zu stimulieren, liegt die Vermutung nahe, dass Muskel-Satellitenzellen auf die LLLT gut ansprechen und diese Therapie genutzt werden könnte, um Muskeln zu reparieren. Darüber hinaus ist die Fähigkeit der LLLT, Entzündungen zu reduzieren und oxidativen Stress zu verringern auch in Fällen von Muskelermüdung und -verletzungen vorteilhaft. Der vorliegende Review-Artikel gibt einen Überblick über die aktuelle Literatur zum Thema LLLT und Muskeln und umfasst sowohl vorklinische Tierversuche als auch klinische Studien am Menschen. Von den Forschungsergebnissen können Sportler, Menschen mit Muskelverletzungen und Patienten, die an einer Muskeldystrophie vom Typ Duchenne erkrankt sind, gleichermaßen profitieren.

Keywords: low level laser therapy; muscle fatigue; muscle injury; mitochondria; ATP; reactive oxygen species; satellite cells; Low-Level-Laser-Therapie; Muskelermüdung; Muskelverletzung; Mitochondrien; ATP; reaktive Sauerstoffspezies; Satellitenzellen

About the article

Corresponding author: Michael R. Hamblin, BAR414, Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA


Received: 2012-08-20

Revised: 2012-09-12

Accepted: 2012-09-19

Published Online: 2012-11-08

Published in Print: 2012-11-01


Citation Information: Photonics & Lasers in Medicine, Volume 1, Issue 4, Pages 267–286, ISSN (Online) 2193-0643, ISSN (Print) 2193-0635, DOI: https://doi.org/10.1515/plm-2012-0032.

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