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Licensed Unlicensed Requires Authentication Published by De Gruyter December 9, 2013

Research of biocompatibility on bioactive films fabricated using oxygen plasma immersion ion implantation

  • Wei-Fang Lee , Hsi-Jen Chiang , Che-Tong Lin , Keng-Liang Ou and Pei-Wen Peng EMAIL logo

Abstract

In the present study, a nanoporous, biocompatible titanium dioxide (TiO2) film was formed on the surface of titanium, using oxygen plasma immersion ion implantation (OPIII), and the influence of this film on the bio-functionalization, including the proliferation and differentiation properties of MG-63 osteoblast-like cells, was analyzed and investigated. The OPIII-treated surface was characterized by X-ray photoelectron, which showed that a TiOx layer was formed on Ti substrates. This TiOx surface exhibited nanoscale surface roughness in the form of nanoporous structures. The results also revealed that MG-63 cells expressed increased proliferation on the OPIII-treated surface as compared with the untreated Ti substrate. The Ti specimens treated with plasma energy of 1 kW revealed better expression of alkaline phosphatase (ALP) activity and showed higher average surface roughness than untreated specimens. Thus, it can be concluded that bioactivity of Ti implants can potentially be improved by OPIII.


Corresponding author: Pei-Wen Peng, School of Dental Technology, Taipei Medical University, Taipei 110, Taiwan, e-mail:

Acknowledgments

The authors would like to thank Yu-Hao Chan and Yi-Yu Chen for participation in experiments. The authors also acknowledge financial support of research by the project of Cathy General Hospital – Taipei Medical University, under the grant number of 100CGH-TMU-09.

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Received: 2013-9-6
Accepted: 2013-10-17
Published Online: 2013-12-9
Published in Print: 2014-5-1

©2014 by Walter de Gruyter Berlin/Boston

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