Official Journal of the International Society of Pteridinology
Editor-in-Chief: Fuchs, Dietmar
IMPACT FACTOR 2018: 0.531
CiteScore 2018: 0.67
SCImago Journal Rank (SJR) 2018: 0.195
Source Normalized Impact per Paper (SNIP) 2018: 0.318
ICV 2018: 145.86
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L-tyrosine, the substrate for tyrosinase. In this report, we present evidence that 6-BH4 and other tetrahydropterins, have the capacity to regulate tyrosinase activity directly by a specific uncompetitive mechanism. This fine control of tyrosinase activity/melanogenesis in the human epiidermis depends on the redox equilibrium 6-BH4 ↔ dihydropterin ↔ 6-biopterin. The accumulation of 6-biopterin is cytotoxic to normal human melanocytes.
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