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Pteridines

Official Journal of the International Society of Pteridinology

Editor-in-Chief: Fuchs, Dietmar


IMPACT FACTOR 2018: 0.531

CiteScore 2018: 0.67

SCImago Journal Rank (SJR) 2018: 0.195
Source Normalized Impact per Paper (SNIP) 2018: 0.318

ICV 2018: 145.86

Open Access
Online
ISSN
2195-4720
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Volume 6, Issue 3

Issues

Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins

Karin U. Schallreuter-Wood / John M. Wood
Published Online: 2013-05-03 | DOI: https://doi.org/10.1515/pteridines.1995.6.3.101

Summary

Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L-tyrosine, the substrate for tyrosinase. In this report, we present evidence that 6-BH4 and other tetrahydropterins, have the capacity to regulate tyrosinase activity directly by a specific uncompetitive mechanism. This fine control of tyrosinase activity/melanogenesis in the human epiidermis depends on the redox equilibrium 6-BH4 ↔ dihydropterin ↔ 6-biopterin. The accumulation of 6-biopterin is cytotoxic to normal human melanocytes.

About the article

Published Online: 2013-05-03

Published in Print: 1995-08-01


Citation Information: Pteridines, Volume 6, Issue 3, Pages 101–103, ISSN (Online) 2195-4720, ISSN (Print) 0933-4807, DOI: https://doi.org/10.1515/pteridines.1995.6.3.101.

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[1]
Karin U. Schallreuter, Wayne D. Beazley, Nigel A. Hibberts, Desmond J. Tobin, John M. Wood, and Ralf Paus
Journal of Investigative Dermatology, 1998, Volume 111, Number 4, Page 545

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