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Pteridines

Official Journal of the International Society of Pteridinology

Editor-in-Chief: Fuchs, Dietmar


IMPACT FACTOR 2018: 0.531

CiteScore 2018: 0.67

SCImago Journal Rank (SJR) 2018: 0.195
Source Normalized Impact per Paper (SNIP) 2018: 0.318

ICV 2018: 145.86

Open Access
Online
ISSN
2195-4720
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Volume 17, Issue 1

Issues

Serial Analysis of Tryptophan Degradation and Neopterin Formation in an otherwise Healthy Individual before and during an Infectious Episode

Leonhard Huber
  • Clinical Department of Medical Psychology and Psychotherapy, Innsbruck Medical University, Innsbruck, Austria
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/ Christiana Winkler
  • Division of Biological Chemistry, Biocentre, Innsbruck Medical University, and Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
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/ Katharina Schroecksnadel
  • Division of Biological Chemistry, Biocentre, Innsbruck Medical University, and Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
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/ Willi Geser / Christian Schubert
  • Clinical Department of Medical Psychology and Psychotherapy, Innsbruck Medical University, Innsbruck, Austria
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/ Prof. Dr. Dietmar Fuchs
  • Corresponding author
  • Division of Biological Chemistry, Biocentre , Innsbruck Medical University, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria, Phone: +43 512 507 3519, FAX: +43 512 5072 865
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Published Online: 2013-08-10 | DOI: https://doi.org/10.1515/pteridines.2006.17.1.25

Abstract

Thl-type cytokine interferon-y induces neopterin production in human monocyte-derived macrophages and it stimulates enzyme indoleamine (2,3)-dioxygenase (IDO) which converts tryptophan to kynurenine in various cells. In an integrative single-case study, a healthy, 27-year-old female had collected her entire urine in 12-hour (= I lag) intervals on 56 consecutive days. Neopterin, tryptophan, kynurenine and Creatinine concentrations were determined using HPLC. The kynurenine to tryptophan ratio (kyn/trp) was calcuiated as an index for IDO activity. Within the Observation period, the woman experienced an infection episode presenting with vomiting and headache, however, not serologically verified. During this period, strong increases in both urinary kyn/trp and neopterin to Creatinine concentrations were observed, and thcrc was a significant correlation between neopterin/creatinine and kyn/trp at the same day (rs =0.334, p <0.001). However, adjusted cross-correlational analysis revealed that accelerated tryptophan degradation preceded increases in neopterin by 24 to 36 hours (24h: r =0.185, 36h: r =0.408; both p <0.05). Our Observation confirms the dose relationship between neopterin production and tryptophan degradation under real-life conditions.

Keywords : tryptophan; indoleamine (2,3)-dioxygenase; neopterin; infection; time series

About the article

Published Online: 2013-08-10

Published in Print: 2006-02-01


Citation Information: Pteridines, Volume 17, Issue 1, Pages 25–30, ISSN (Online) 2195-4720, ISSN (Print) 0933-4807, DOI: https://doi.org/10.1515/pteridines.2006.17.1.25.

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