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Pteridines

Official Journal of the International Society of Pteridinology

Editor-in-Chief: Fuchs, Dietmar


IMPACT FACTOR 2018: 0.531

CiteScore 2018: 0.67

SCImago Journal Rank (SJR) 2018: 0.195
Source Normalized Impact per Paper (SNIP) 2018: 0.318

ICV 2018: 145.86

Open Access
Online
ISSN
2195-4720
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Volume 18, Issue 1

Issues

Urinary Neopterin in Patients Treated with Gefitinib

Hana Kalabova
  • Departments of Oncology & Radiotherapy Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Josef Dvorak
  • Departments of Oncology & Radiotherapy Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Radomír Hyspler
  • Departments of Gerontology & Metabolic Care, Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Alena Ticha
  • Departments of Gerontology & Metabolic Care, Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Lenka Krcmova
  • Departments of Gerontology & Metabolic Care, Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Lubor Urbanek
  • Departments of Gerontology & Metabolic Care, Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Dagmar Solichova
  • Departments of Gerontology & Metabolic Care, Charles University Medical School & Teaching Hospital, Hradec Kralove, Czech Republic
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/ Prof. MUDr. Bohuslav Melichar Ph.D.
  • Corresponding author
  • Klinika onkologie a radioterapie, Lekarska fakulta Univerzity Karlovy a Fakultni nemocnice, Budova 23, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Tel +420-49-5834574; fax +420-49-5832081
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Published Online: 2013-08-10 | DOI: https://doi.org/10.1515/pteridines.2007.18.1.95

Abstract

Inhibitors of epidermal growth factor receptor (EGFR), including low molecular weight inhibitor erlotinib and gefitinib, have been demonstrated to be active antitumor agents in patients with non-small cell lung carcinoma and head and neck carcinomas. Increased concentrations of urinary neopterin, an indicator of systemic immune activation, have also been reported in patients with lung carcinoma and head and neck carcinomas. EGFR blockade has been reported to induce immune activation. We have measured, using high performance liquid chromatography, urinary neopterin in patients with non-small cell lung carcinoma and head and neck carcinomas treated with gefitinib. Intestinal permeability was also investigated at baseline by measuring, using capillary gas chromatography, urinary xylose, mannitol and lactulose after oral challenge. Compared to controls, urinary neopterin was significantly increased in patients with non-small cell lung carcinoma. No significant change in urinary neopterin was observed during the therapy with gefitinib. A significant correlation was observed between urinary neopterin and xylose absorption (rs = -0.58, p <0.05), lactulose/mannitol (rs = 0.75, p <0.01), and lactulose/ xylose (rs = 0.62, p <0.05) ratios. In conclusion, EGFR blockade had no effect on systemic immune activation, evaluated with urinary neopterin. A significant correlation has been observed between urinary neopterin and parameters of intestinal permeability and absorption.

Keywords : gefitinib; head and neck cancer; intestinal permeability; lung cancer; neopterin

About the article

Published Online: 2013-08-10

Published in Print: 2007-02-01


Citation Information: Pteridines, Volume 18, Issue 1, Pages 95–100, ISSN (Online) 2195-4720, ISSN (Print) 0933-4807, DOI: https://doi.org/10.1515/pteridines.2007.18.1.95.

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