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Pteridines

Official Journal of the International Society of Pteridinology

Editor-in-Chief: Fuchs, Dietmar

4 Issues per year


IMPACT FACTOR 2016: 0.621

CiteScore 2016: 0.42

SCImago Journal Rank (SJR) 2016: 0.192
Source Normalized Impact per Paper (SNIP) 2016: 0.184

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2195-4720
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Volume 22, Issue 1 (Feb 2011)

Issues

Urinary Neopterin in Patients with Metastatic Colon Cancer Treated with Patupilone

Bohuslav Melichar M.D., Ph.D.
  • Corresponding author
  • Professor and Head, Department of Oncology, Palacký University Medical School & Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic phone: +420-588444288, fax: +420-588442522
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/ Hana Kalábová
  • Departments of Oncology & Radiotherapy, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Lenka Krčmová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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/ Markéta Kašparová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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/ Jiří Plíšek
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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/ Cerman Jr. Jaroslav
  • Departments of Surgery, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Petra Holečková
  • Institute of Experimental Neurosurgery, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Dagmar Solichová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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Published Online: 2013-08-10 | DOI: https://doi.org/10.1515/pteridines.2011.22.1.61

Abstract

Despite increased efficacy of regimens combining cytotoxic drugs and targeted agents, most patients with metastatic colorectal cancer will ultimately die of the disease. Only a limited number of drugs have reproducible activity in therapy of this tumor, and new active agents are urgently needed. Promising results in the therapy of metastatic colorectal cancer have been reported for patupilone, an epothilone analogue. Similarly to taxanes, the cytotoxic mechanism of epothilones involves the stabilization of microtubules. Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, including colorectal cancer. Neopterin concentrations were reported to increase during the administration of cytotoxic agents, including taxane-based chemotherapy. We have studied serum neopterin in patients with colorectal cancer before and during the therapy with patupilone. Urinary neopterin/creatinine concentrations were determined with highperformance liquid chromatography. Increased urinary neopterin concentrations were observed at baseline in the majority of the patients. In most patients, neopterin concentrations further increased during the therapy, and a significant increase of urinary neopterin was observed in patients with normal baseline neopterin concentrations. A trend of decreased survival was observed for patients with high initial neopterin concentration. In conclusion, urinary neopterin is increased in colorectal cancer patients presenting for second or higher line of treatment. An increase of urinary neopterin during patupilone therapy suggests an activation of immune response by this agent.

Keywords : colon cancer; neopterin; patupilone

About the article

Published Online: 2013-08-10

Published in Print: 2011-02-01


Citation Information: Pteridines, ISSN (Online) 2195-4720, ISSN (Print) 0933-4807, DOI: https://doi.org/10.1515/pteridines.2011.22.1.61.

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