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Pteridines

Official Journal of the International Society of Pteridinology

Editor-in-Chief: Fuchs, Dietmar

4 Issues per year


IMPACT FACTOR 2016: 0.621

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2195-4720
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Volume 22, Issue 1 (Feb 2011)

Issues

Correlation of Peripheral Blood CD14+CD16+ Monocytes, Urinary Neopterin and the Risk Factors of Atherosclerosis in Patients with Breast Carcinoma

Pavlína Králíčková
  • Departments of Immunology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Hana Kalábová
  • Departments of Oncology & Radiotherapy, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Lenka Krčmová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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/ Markéta Kašparová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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/ Jiří Plíšek
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
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/ Leoš Ungermann
  • Departments of Radiology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Doris Vokurková
  • Departments of Immunology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Radomír Hyšpler
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Miroslav Pecka
  • Departments of Hematology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Vlastislav Šrámek
  • Department of Oncology, Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic
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/ Hana Študentová
  • Department of Oncology, Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic
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/ Michaela Zezulová
  • Department of Oncology, Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic
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/ Dagmar Solichová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
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/ Bohuslav Melichar M.D., Ph.D.
  • Corresponding author
  • Professor and Head, Department of Oncology, Palacký University Medical School & Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic phone: +420-588444288; fax: +420-588442522
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Published Online: 2013-08-10 | DOI: https://doi.org/10.1515/pteridines.2011.22.1.66

Abstract

Monocytes/macrophages are thought to play a fundamental role in the development of vascular lesions in atherosclerosis. In the present study, we evaluated circulating CD14+CD16+ monocytes, laboratory parameters of the risk of atherosclerosis, including serum cholesterol, homocysteine and C-reactive protein, urinary neopterin, serum a-tocopherol and retinol along with carotid intima-media thickness in patients with breast carcinoma. A significant correlation was observed between the absolute numbers of CD14+CD16+ monocytes, serum HDL cholesterol and triglyceride concentrations. In conclusion, present data extend the observation of an association between peripheral blood CD14+CD16+ monocyte counts and lipid metabolism to cancer patients. No correlation of CD14+CD16+ monocyte counts with urinary neopterin concentrations was observed.

Keywords : breast cancer; CD14+CD16+ monocytes; cholesterol; intima-media thickness; neopterin

About the article

Published Online: 2013-08-10

Published in Print: 2011-02-01


Citation Information: Pteridines, ISSN (Online) 2195-4720, ISSN (Print) 0933-4807, DOI: https://doi.org/10.1515/pteridines.2011.22.1.66.

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