Official Journal of the International Society of Pteridinology
Editor-in-Chief: Fuchs, Dietmar
4 Issues per year
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Prognostic Significance of Serum Neopterin in Patients with Esophageal Carcinoma
- Corresponding author
- Professor and Head, Department of Oncology, Palacký University, Medical School & Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic phone: +420-588444288; fax: +420-588442522
- Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
- Other articles by this author:
- De Gruyter OnlineGoogle Scholar
Increased concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with carcinoma of the esophagus are still very limited. We have studied serum neopterin in 45 patients with histologically verified carcinoma of the esophagus. Serum neopterin was determined with radioimmunoassay. Neopterin concentrations above median (6.5 nmol/L) were associated with inferior prognosis in patients with early esophageal carcinoma. In multivariate analysis, tumor stage and serum neopterin were predictors of survival in patients without distant metastases. In conclusion, serum neopterin is an independent prognostic factor in patients with esophageal carcinoma.
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