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Pteridines

Official Journal of the International Society of Pteridinology

Editor-in-Chief: Fuchs, Dietmar

4 Issues per year


IMPACT FACTOR 2016: 0.621

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2195-4720
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Volume 23, Issue 1 (Feb 2012)

Issues

Prognostic Significance of Serum Neopterin in Patients with Esophageal Carcinoma

Jan Cincibuch
  • Department of Oncology Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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/ Karel Cwiertka
  • Department of Oncology Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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/ Hana Procházková-Študentová
  • Department of Oncology Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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/ Michaela Zezulová
  • Department of Oncology Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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/ Cestmír Neoral
  • Department of Surgery, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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/ Hana Kalábová
  • Department of Oncology Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic
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/ Lenka Krcmová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
  • Department of Analytical Chemistry, Charles University School of Pharmacy, Czech Republic
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/ Eva Malírová
  • Department of Nuclear Medicine Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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/ Dagmar Solichová
  • Departments of Gerontology & Metabolic Care, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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/ Bohuslav Melichar M.D., Ph.D.
  • Corresponding author
  • Professor and Head, Department of Oncology, Palacký University, Medical School & Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic phone: +420-588444288; fax: +420-588442522
  • Department of Medicine, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic
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Published Online: 2013-08-13 | DOI: https://doi.org/10.1515/pteridines.2012.23.1.22

Abstract

Increased concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with carcinoma of the esophagus are still very limited. We have studied serum neopterin in 45 patients with histologically verified carcinoma of the esophagus. Serum neopterin was determined with radioimmunoassay. Neopterin concentrations above median (6.5 nmol/L) were associated with inferior prognosis in patients with early esophageal carcinoma. In multivariate analysis, tumor stage and serum neopterin were predictors of survival in patients without distant metastases. In conclusion, serum neopterin is an independent prognostic factor in patients with esophageal carcinoma.

Keywords : esophageal carcinoma; neopterin; prognosis

About the article

Published Online: 2013-08-13

Published in Print: 2012-02-01


Citation Information: Pteridines, ISSN (Online) 2195-4720, ISSN (Print) 0933-4807, DOI: https://doi.org/10.1515/pteridines.2012.23.1.22.

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