Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Radiochimica Acta

International Journal for chemical aspects of nuclear science and technology

Editor-in-Chief: Qaim, Syed M.

IMPACT FACTOR 2018: 1.339

CiteScore 2018: 1.20

SCImago Journal Rank (SJR) 2018: 0.333
Source Normalized Impact per Paper (SNIP) 2018: 0.720

See all formats and pricing
More options …
Volume 93, Issue 7


Synthesis and biodistribution of 99mTc-Vancomycin in a model of bacterial infection

Samina Roohi / A. Mushtaq / Salman A. Malik
Published Online: 2009-09-25 | DOI: https://doi.org/10.1524/ract.2005.93.7.415


Vancomycin Hydrochloride is an antibiotic produced by the growth of certain strains of Streptomyces orientalis. As Vancomycin Hydrochloride is poorly absorbed after oral administration; it is given intravenously for therapy of systemic infections. Vancomycin was labeled with technetium-99m pertechnetate using SnCl2·2H2O as reducing agent. The labeling efficiency depends on ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of 99mTc-Vancomycin was determined by thin layer chromatography. Biodistribution studies of 99mTc-Vancomycin were performed in a model of bacterial infection in Sprague–Dawley rats. A significantly higher accumulation of 99mTc-Vancomycin was seen at sites of S. aureus infected animals. Whereas uptake of 99mTc-Vancomycin in turpentine inflamed rats were quite low.

About the article

Received: 2004-10-04

Accepted: 2005-03-22

Published Online: 2009-09-25

Published in Print: 2005-07-01

Citation Information: Radiochimica Acta, Volume 93, Issue 7, Pages 415–418, ISSN (Online) 2193-3405, ISSN (Print) 0033-8230, DOI: https://doi.org/10.1524/ract.2005.93.7.415.

Export Citation

© Oldenbourg Wissenschaftsverlag, München.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Mick M. Welling, Albertus W. Hensbergen, Anton Bunschoten, Aldrik H. Velders, Meta Roestenberg, and Fijs W. B. van Leeuwen
Clinical and Translational Imaging, 2019
Syed Ali Raza Naqvi, Samina Roohi, Anam Iqbal, Tauqir A. Sherazi, Ameer Fawad Zahoor, and Muhammad Imran
Molecular Biology Reports, 2018, Volume 45, Number 5, Page 1457
Ebru Salmanoglu, Sung Kim, and Mathew L. Thakur
Seminars in Nuclear Medicine, 2018, Volume 48, Number 2, Page 86
Jyotibon Dutta, Tricia Naicker, Thomas Ebenhan, Hendrik G. Kruger, Per I. Arvidsson, and Thavendran Govender
European Journal of Medicinal Chemistry, 2017, Volume 133, Page 287
Muhammad Usman Akbar, Tanveer Hussain Bokhari, Muhammad Khalid, Muhammad Razeen Ahmad, Samina Roohi, Saira Hina, Sajid Mehmood, Muhammad Sohaib, and Tania Jabbar
Chemical Biology & Drug Design, 2017, Volume 90, Number 3, Page 425
Muhammad Usman Akbar, Tanveer Hussain Bokhari, Samina Roohi, Khalid Mahmood Zia, Mohammad Zuber, Nadia Parveen, and Narmeen Ali
Russian Journal of Bioorganic Chemistry, 2016, Volume 42, Number 5, Page 491
S. Auletta, F. Galli, C. Lauri, D. Martinelli, I. Santino, and Alberto Signore
Clinical and Translational Imaging, 2016, Volume 4, Number 4, Page 229
Chris Tsopelas
The Scientific World Journal, 2015, Volume 2015, Page 1
Douglas R. Rice, Adam J. Plaunt, Serhan Turkyilmaz, Miles Smith, Yuzhen Wang, Mary Rusckowski, and Bradley D. Smith
Molecular Imaging and Biology, 2015, Volume 17, Number 2, Page 204
Saira Hina, Muhammad Ibrahim Rajoka, Samina Roohi, Asma Haque, and Muhammad Qasim
Applied Biochemistry and Biotechnology, 2014, Volume 174, Number 4, Page 1420
A. Bunschoten, M. M. Welling, M. F. Termaat, M. Sathekge, and F. W. B. van Leeuwen
Bioconjugate Chemistry, 2013, Volume 24, Number 12, Page 1971
Dipak Kumar Nayak, Rinku Baishya, Kamal Krishna Halder, Tuhinadri Sen, Bharat R. Sarkar, Shantanu Ganguly, M. K. Das, and Mita Chatterjee Debnath
Metallomics, 2012, Volume 4, Number 11, Page 1197
Rizwana Zahoor, Samina Roohi, Mushtaq Ahmad, Zafar Iqbal, Nagina Amir, Saima Tariq, and Paul. B. Savage
Journal of Radioanalytical and Nuclear Chemistry, 2013, Volume 295, Number 2, Page 841
Sankha Chattopadhyay, Mayuri Ghosh, Sucharita Sett, Malay Kanti Das, Susmita Chandra, Kakali De, Mridula Mishra, Samarendu Sinha, Bharat Ranjan Sarkar, and Shantanu Ganguly
Applied Radiation and Isotopes, 2012, Volume 70, Number 10, Page 2384
Faheem A. Rizvi, Tanveer H. Bokhari, S. Roohi, and A. Mushtaq
Journal of Radioanalytical and Nuclear Chemistry, 2012, Volume 293, Number 1, Page 303
Kasim Ocakoglu, Elif Bayrak, Mehmet Onursal, Osman Yilmaz, Fatma Yurt Lambrecht, and Alfred R. Holzwarth
Applied Radiation and Isotopes, 2011, Volume 69, Number 9, Page 1165
Syed Qaiser Shah, Aakif Ullah Khan, and Muhammad Rafiullah Khan
Journal of Labelled Compounds and Radiopharmaceuticals, 2011, Volume 54, Number 3, Page 145
Samina Roohi, Nagina Amir, Mushtaq Ahmed, Paul B. Savage, S. M. Salahuddin, and Mustanser Jehangir
Radiochimica Acta, 2009, Volume 97, Number 1
Fatma Yurt Lambrecht
Annals of Nuclear Medicine, 2011, Volume 25, Number 1, Page 1
F. Yurt Lambrecht, O. Yilmaz, E. Bayrak, G. Kocagozoglu, and K. Durkan
Journal of Radioanalytical and Nuclear Chemistry, 2010, Volume 283, Number 2, Page 503
F. Yurt Lambrecht, O. Yilmaz, K. Durkan, P. Unak, and E. Bayrak
Journal of Radioanalytical and Nuclear Chemistry, 2009, Volume 281, Number 3, Page 415
F. Yurt Lambrecht, O. Yilmaz, P. Unak, B. Seyitoglu, K. Durkan, and H. Baskan
Journal of Radioanalytical and Nuclear Chemistry, 2008, Volume 277, Number 2, Page 491

Comments (0)

Please log in or register to comment.
Log in