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Radiochimica Acta

International Journal for chemical aspects of nuclear science and technology

Editor-in-Chief: Qaim, Syed M.


IMPACT FACTOR 2017: 1.202

CiteScore 2017: 1.22

SCImago Journal Rank (SJR) 2017: 0.409
Source Normalized Impact per Paper (SNIP) 2017: 0.869

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2193-3405
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Volume 96, Issue 12

Issues

Electrophilic synthesis of 6-[18F]fluoro-L-DOPA using post-target produced [18F]F2

Sarita Forsback / Olli Eskola
  • 1 Turku PET Centre, Radiopharmaceutical Chemistry Laboratory and Accel, FI-20500 Turku, Finnland
  • Other articles by this author:
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/ Merja Haaparanta
  • 2 Turku PET Centre, Radiopharmaceutical Chemistry Laboratory and Accel, FI-20500 Turku, Finnland
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/ Jörgen Bergmann
  • 3 Turku PET Centre, Radiopharmaceutical Chemistry Laboratory and Accel, FI-20500 Turku, Finnland
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/ Olof Solin
  • 4 Turku PET Centre, Radiopharmaceutical Chemistry Laboratory and Accel, FI-20500 Turku, Finnland
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Published Online: 2009-09-25 | DOI: https://doi.org/10.1524/ract.2008.1527

Abstract

New diagnostic uses of 6-[ 18F]fluoro-L-DOPA ([ 18F]FDOPA) for endocrine cancers and for focal hyperinsulism of infancy have renewed interest in simple and reproducible methods to synthesize it in high quantity. Fluorodestannylation is a simple and regioselective means to produce [ 18F]FDOPA. We have successfully used post-target produced [ 18F]F2 as a labeling agent in fluorodestannylation. We are able to produce in one synthesis enough [ 18F]FDOPA for several human PET studies at Turku PET Centre. The average radiochemical yield in 50 syntheses was 6.4±1.7% (calculated from [ 18F]F), with radiochemical purity >98% and mean specific radioactivity at the end of synthesis 3.7±0.9 GBq/μmol. With this method the amounts of the reagents used in the synthesis are considerably reduced in comparison to other electrophilic labeling approaches. Thus the manipulations during the synthesis and the purification of the product are simplified.

Keywords: [18F]FDOPA; Fluorodestannylation; Electrophilic fluorination; Specific radioactivity; PET

About the article

* Correspondence address: Turku PET Centre, Radiopharmaceutical Chemistry Laboratory and Accel, Porthaninkatu 3, FI-20500 Turku, Finnland


Published Online: 2009-09-25

Published in Print: 2008-12-01


Citation Information: Radiochimica Acta, Volume 96, Issue 12, Pages 845–848, ISSN (Online) 2193-3405, ISSN (Print) 0033-8230, DOI: https://doi.org/10.1524/ract.2008.1527.

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