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Radiochimica Acta

International Journal for chemical aspects of nuclear science and technology

Editor-in-Chief: Qaim, Syed M.


IMPACT FACTOR 2018: 1.339

CiteScore 2018: 1.20

SCImago Journal Rank (SJR) 2018: 0.333
Source Normalized Impact per Paper (SNIP) 2018: 0.720

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2193-3405
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Volume 97, Issue 1

Issues

Preparation and biological evaluation of [67Ga]-labeled-superparamagnetic nanoparticles in normal rats

A. R. Jalilian / A. Panahifar
  • 1 Department of Engineering and Technical, Islamic Azad University, Science and Research Bran, Tehran, Iran
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/ M. Mahmoudi
  • 2 Sharif University of Technology, Institute for Nanoscience and Nanotechnology, Tehran, Iran
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/ M. Akhlaghi
  • 3 Nuclear Research Center for Agriculture and Medicine, Cyclotron and Nuclear Medicine Department, Karaj, Iran
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/ A. Simchi
  • 4 Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Institute for Nanoscience and NanotechnologySharif, Tehran, Iran
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Published Online: 2009-09-25 | DOI: https://doi.org/10.1524/ract.2009.1566

Abstract

Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe3+/Fe2+=2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The biodistribution of the radiolabeled SPION was checked in normal male rats up to 24 h compared to free Ga3+ cation biodistribution. The data strongly support the alteration of the tracer accumulation in reticuluendothelial system while the stability of the complex is highly retained.

Keywords: Gallium-67; Superparamagnetic iron oxide nanoparticles; Radiolabeling; Stability; Biodistribution

About the article

* Correspondence address: Nuclear Medicine Research Group, Agricultural,, Medical and Industrial Research School (AMIRS), P.O. Box 31485-4395, Karaj, Iran,


Published Online: 2009-09-25

Published in Print: 2009-01-01


Citation Information: Radiochimica Acta International journal for chemical aspects of nuclear science and technology, Volume 97, Issue 1, Pages 51–56, ISSN (Print) 0033-8230, DOI: https://doi.org/10.1524/ract.2009.1566.

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